Results 111 to 120 of about 15,705 (275)

Epidemic Alphaviruses: Ecology, Emergence and Outbreaks

Microorganisms, 2020
Over the past century, the emergence/reemergence of arthropod-borne zoonotic agents has been a growing public health concern. In particular, agents from the genus Alphavirus pose a significant risk to both animal and human health.
Sasha R. Azar, R. K. Campos, Nicholas A Bergren, Vidyleison Neves Camargos, S. Rossi   +4 more
semanticscholar   +1 more source

Alphaviruses in Gene Therapy [PDF]

Viruses, 2009
Alphaviruses are enveloped single stranded RNA viruses, which as gene therapy vectors provide high-level transient gene expression. Semliki Forest virus (SFV), Sindbis virus (SIN) and Venezuelan Equine Encephalitis (VEE) virus have been engineered as efficient replication-deficient and -competent expression vectors.
openaire   +6 more sources

Structure‐Based Rational Design of a Selective Hydrolase Inhibitor of the Severe Acute Respiratory Syndrome Coronavirus‐2 Nsp3 Macrodomain

ChemBioChem, Volume 26, Issue 23, November 27, 2025.
Structure‐guided design of a sulfamoyl‐modified analog of GS‐441524 yielded a selective, high‐affinity inhibitor of the SARS‐CoV‐2 macrodomain Nsp3b. The compound occupies the phosphate‐binding pocket, forming a stabilizing hydrogen‐bond network that enhances binding affinity (K_D = 0.86 μM).
Robin Krishnathas, Konstantin S. Mineev, Nikolaos K. Fourkiotis, Franck Touret, Christos Sideras‐Bisdekis, Aikaterini C. Tsika, Santosh Lakshmi Gande, Verena Linhard, Sridhar Sreeramulu, Frank Lennartz, Manfred S. Weiss, Bruno Coutard, Georgios A. Spyroulias, Harald Schwalbe   +13 more
wiley   +1 more source

Identification of Broad-Spectrum Antiviral Compounds by Targeting Viral Entry

Viruses, 2019
Viruses are a major threat to human health and economic well-being. In recent years Ebola, Zika, influenza, and chikungunya virus epidemics have raised awareness that infections can spread rapidly before vaccines or specific antagonists can be made ...
Michela Mazzon, Ana Maria Ortega-Prieto, Douglas Imrie, Christin Luft, Lena Hess, Stephanie Czieso, Joe Grove, Jessica Katy Skelton, Laura Farleigh, Joachim J. Bugert, Edward Wright, Nigel Temperton, Richard Angell, Sally Oxenford, Michael Jacobs, Robin Ketteler, Marcus Dorner, Mark Marsh   +17 more
doaj   +1 more source

Epidemiological and Genomic Characterisation of Middelburg and Sindbis Alphaviruses Identified in Horses with Febrile and Neurological Infections, South Africa (2014–2018) [PDF]

, 2022
Isabel Fourie, Jumari Snyman, J. H. Williams, Arshad Ismail, Petrus Jansen van Vuren, Marietjie Venter   +5 more
openalex   +1 more source

A Viral RNA Silencing Suppressor Modulates Reactive Oxygen Species Levels to Induce the Autophagic Degradation of Dicer‐Like and Argonaute‐Like Proteins

Advanced Science, Volume 12, Issue 44, November 27, 2025.
Understanding the virus‐host arms race has been a fascinating topic in virology; contributing significantly to the development of treatments and control strategies for viral diseases. CHV1 employs a sophisticated counter‐defense mechanism in its fungal host by utilizing a viral silencing suppressor to inhibit fungal FMN reductase; thereby modulating ...
Shiyu Zhai, Tianxing Pang, Shiyu Peng, Shenshen Zou, Zhiping Deng, Nobuhiro Suzuki, Zhensheng Kang, Ida Bagus Andika, Liying Sun   +8 more
wiley   +1 more source

Trans-Amplifying RNA: A Journey from Alphavirus Research to Future Vaccines

Viruses
Replicating RNA, including self-amplifying RNA (saRNA) and trans-amplifying RNA (taRNA), holds great potential for advancing the next generation of RNA-based vaccines.
Ayşegül Yıldız, Cristian Răileanu, Tim Beissert   +2 more
doaj   +1 more source

Chemokine receptors as important regulators of pathogenesis during arboviral encephalitis

Frontiers in Cellular Neuroscience, 2014
The central nervous system (CNS) is a highly complex network comprised of long-lived neurons and glial cells. Accordingly, numerous mechanisms have evolved to tightly regulate the initiation of inflammatory responses within the brain.
Daniela eMichlmayr, Jean K Lim
doaj   +1 more source

Site-directed mutagenesis of the proposed catalytic amino acids of the Sindbis virus capsid protein autoprotease [PDF]

, 1990
The structural proteins of Sindbis virus are translated as a polyprotein precursor that is cleaved upon translation. The capsid protein is postulated to be a serine protease that releases itself from the N terminus of the nascent polyprotein by ...
Hahn, Chang S., Strauss, James H.
core  

Small RNA analysis in Sindbis virus infected human HEK293 cells [PDF]

, 2013
In contrast to the defence mechanism of RNA interference (RNAi) in plants and invertebrates, its role in the innate response to virus infection of mammals is a matter of debate.
A Chakrabarti, A Mortazavi, A Saumet, Andras Donaszi-Ivanov, BC Ho, BR Cullen, BR tenOever, CL Campbell, CM Cirimotich, CW Burke, E Gottwein, EG Strauss, EM Morazzani, ER Mardis, EY Choy, F Ma, F Weber, G Gatto, G Szittya, I Mohorianu, I Mohorianu, IP Greene, Irina Mohorianu, J Fang, JI Henke, JK Ahluwalia, JR Abend, JY Leung, K Prufer, KJ Ishii, KL McKnight, KM Myles, KW Witwer, L Du, M Hariharan, MB Stocks, MC Saleh, ML Metzker, MP Gantier, N Vodovar, P Parameswaran, Penny P. Powell, PV Maillard, RL Pilcher, RL Skalsky, RP Kincaid, RW Williams, S Griffiths-Jones, S Koyama, S Moxon, SW Ding, T Kawai, Tamas Dalmay, V Stollar, W Hou, WB Klimstra, X Lei, Y Kim, Y Li, YQ Wu, Zach N. Adelman, ZN Adelman   +61 more
core   +3 more sources