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Modeling complement activation on human glomerular microvascular endothelial cells
Frontiers in Immunology, 2023 IntroductionAtypical hemolytic uremic syndrome (aHUS) is a rare kidney disease caused by dysregulation of the complement alternative pathway. The complement dysregulation specifically leads to damage to the glomerular endothelium.
Kes H. Stevens +14 more
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The alternative complement pathway revisited [PDF]
Journal of Cellular and Molecular Medicine, 2008 Introduction Methods to study and modify the alternative pathway Influence of AP amplification on the effect of specific activation of the other initial pathways Properdin Influence of AP in deficiency states Complement in sepsis Concluding remarks AbstractAlternative pathway amplification plays a major role for the final effect of initial specific ...
Tom Eirik Mollnes, Morten Harboe
openaire +2 more sources
Frontiers in Immunology, 2018 Skin blisters of pemphigus foliaceus (PF) present concomitant deposition of autoantibodies and components of the complement system (CS), whose gene polymorphisms are associated with susceptibility to different autoimmune diseases. To investigate these in
Valéria Bumiller-Bini +7 more
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Lower glycolysis carries a higher flux than any biochemically possible alternative [PDF]
Nature Communications 6, 8427 (2015), 2014 The universality of many pathways of core metabolism suggests a strong role for evolutionary selection, but it remains unclear whether existing pathways have been selected from a large or small set of biochemical possibilities. To address this question, we construct "in silico" all possible biochemically feasible alternatives to the trunk pathway of ...
arxiv +1 more source
Assessment of the Role of C3(H2O) in the Alternative Pathway
Frontiers in Immunology, 2020 In this study we investigate the hydrolysis of C3 to C3(H2O) and its ability to initiate activation via the alternative pathway (AP) of the complement system.
Karin Fromell +9 more
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Frontiers in Immunology, 2019 Bacterial infections are frequent and severe in patients with diabetes mellitus. Whether diabetes per se induces functional alterations in the complement system hampering activation during infection is unknown.
László József Barkai +6 more
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Autophagy takes an alternative pathway [PDF]
Autophagy, 2010 ATG5 and ATG7 are considered as essential molecules for induction of macroautophagy. However, we found that cells lacking ATG5 or ATG7 can still form autophagosomes/autolysosomes and perform autophagy-mediated protein degradation when subjected to certain stresses.
Shigeomi Shimizu +2 more
openaire +3 more sources
Frontiers in Immunology, 2021 Dysregulation of complement activation causes a number of diseases, including paroxysmal nocturnal hemoglobinuria and atypical hemolytic uremic syndrome.
Emma Ispasanie +10 more
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Nitrogen deprivation induces cross-tolerance of Poa annua callus to salt stress
Biologia Plantarum, 2016 Alternative respiration pathway (AP) is an important pathway which can be induced by environment stresses in plants. In the present study, we show a new mechanism involving the AP in nitrogen deprivation-induced tolerance of Poa annua callus to salt ...
C. Z. Zhao +8 more
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Comparison of dominant and nondominant C3 deposition in primary glomerulonephritis [PDF]
Kidney Research and Clinical Practice, 2023 Background Alternative complement pathway dysregulation plays a key role in glomerulonephritis (GN) and is associated with C3 deposition. Herein, we examined pathological and clinical differences between cases of primary GN with C3-dominant (C3D-GN) and ...
Jiwon Ryu +14 more
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