Results 21 to 30 of about 6,006,467 (356)

A novel assay that characterizes properdin function shows neutrophil-derived properdin has a distinct oligomeric distribution

Frontiers in Immunology, 2023
Properdin acts as an essential positive regulator of the alternative pathway of complement by stabilizing enzymatic convertases. Identical properdin monomers form head-to-tail associations of oligomers in a reported 20:54:26 ratio (most often described ...
Sara R. Moore, Smrithi S. Menon, Neeti S. Galwankar, Sadik A. Khuder, Michael K. Pangburn, Viviana P. Ferreira   +5 more
doaj   +1 more source

The alternative complement pathway revisited [PDF]

Journal of Cellular and Molecular Medicine, 2008
Introduction Methods to study and modify the alternative pathway Influence of AP amplification on the effect of specific activation of the other initial pathways Properdin Influence of AP in deficiency states Complement in sepsis Concluding remarks AbstractAlternative pathway amplification plays a major role for the final effect of initial specific ...
Tom Eirik Mollnes, Morten Harboe
openaire   +2 more sources

Modeling complement activation on human glomerular microvascular endothelial cells

Frontiers in Immunology, 2023
IntroductionAtypical hemolytic uremic syndrome (aHUS) is a rare kidney disease caused by dysregulation of the complement alternative pathway. The complement dysregulation specifically leads to damage to the glomerular endothelium.
Kes H. Stevens, Laura M. Baas, Thea J. A. M. van der Velden, Romy N. Bouwmeester, Niels van Dillen, Eiske M. Dorresteijn, Arjan D. van Zuilen, Jack F. M. Wetzels, Marloes A. H. M. Michels, Marloes A. H. M. Michels, Nicole C. A. J. van de Kar, Lambertus P. van den Heuvel, Lambertus P. van den Heuvel, Lambertus P. van den Heuvel, Lambertus P. van den Heuvel   +14 more
doaj   +1 more source

Decreased Ficolin-3-mediated Complement Lectin Pathway Activation and Alternative Pathway Amplification During Bacterial Infections in Patients With Type 2 Diabetes Mellitus

Frontiers in Immunology, 2019
Bacterial infections are frequent and severe in patients with diabetes mellitus. Whether diabetes per se induces functional alterations in the complement system hampering activation during infection is unknown.
László József Barkai, Emese Sipter, Dorottya Csuka, Zoltán Prohászka, Katrine Pilely, Peter Garred, Nóra Hosszúfalusi   +6 more
doaj   +1 more source

Alternative pathway androgen biosynthesis and human fetal female virilization

Proceedings of the National Academy of Sciences of the United States of America, 2019
Significance In the classic androgen biosynthesis pathway, testosterone is converted to 5α-dihydrotestosterone, a step crucially required for normal male genital virilization.
N. Reisch, A. Taylor, E. Nogueira, D. Asby, V. Dhir, Andrew A. Berry, N. Krone, R. Auchus, C. Shackleton, N. Hanley, W. Arlt   +10 more
semanticscholar   +1 more source

Germline mutations in the alternative pathway of complement predispose to HELLP syndrome.

JCI Insight, 2018
BACKGROUND HELLP (hemolysis, elevated liver enzymes, and low platelets) syndrome is a severe variant of hypertensive disorders of pregnancy affecting approximately 1% of all pregnancies, and has significant maternal and fetal morbidity.
A. Vaught, Evan M. Braunstein, Jagar A. Jasem, Xuan Yuan, I. Makhlin, Solange N. Eloundou, Andrea C. Baines, Samuel A. Merrill, Shruti Chaturvedi, K. Blakemore, C. John Sperati, Robert A. Brodsky   +11 more
semanticscholar   +1 more source

Comparison of dominant and nondominant C3 deposition in primary glomerulonephritis [PDF]

Kidney Research and Clinical Practice, 2023
Background Alternative complement pathway dysregulation plays a key role in glomerulonephritis (GN) and is associated with C3 deposition. Herein, we examined pathological and clinical differences between cases of primary GN with C3-dominant (C3D-GN) and ...
Jiwon Ryu, Eunji Baek, Hyung-Eun Son, Ji-Young Ryu, Jong Cheol Jeong, Sejoong Kim, Ki Young Na, Dong-Wan Chae, Seong Pyo Kim, Su Hwan Kim, Jong Hyun Jhee, Tae Ik Chang, Bum Soon Choi, Ho Jun Chin,   +14 more
doaj   +1 more source

The role of the alternative pathway of complement activation in glomerular diseases

Clinical and Experimental Medicine (Testo stampato), 2018
The complement system (CS) has recently been recognized as a bridge between innate and adaptive immunity that constitutes a very complex mechanism controlling the clearance of pathogens, cellular debris, and immune complexes.
Emilia Łukawska, M. Polcyn-Adamczak, Z. Niemir   +2 more
semanticscholar   +1 more source

Autophagy takes an alternative pathway [PDF]

Autophagy, 2010
ATG5 and ATG7 are considered as essential molecules for induction of macroautophagy. However, we found that cells lacking ATG5 or ATG7 can still form autophagosomes/autolysosomes and perform autophagy-mediated protein degradation when subjected to certain stresses.
Shigeomi Shimizu, Yuya Nishida, Satoko Arakawa   +2 more
openaire   +3 more sources

Nitrogen deprivation induces cross-tolerance of Poa annua callus to salt stress

Biologia Plantarum, 2016
Alternative respiration pathway (AP) is an important pathway which can be induced by environment stresses in plants. In the present study, we show a new mechanism involving the AP in nitrogen deprivation-induced tolerance of Poa annua callus to salt ...
C. Z. Zhao, P. Li, X. M. Wang, P. Li, X. Y. Wang, F. Wang, J. F. Wang, N. Chang, Y. R. Bi   +8 more
doaj   +1 more source