Results 31 to 40 of about 7,204,743 (394)

Searching for pathways involving dressed states in optimal control theory [PDF]

, 2011
Selective population of dressed states has been proposed as an alternative control pathway in molecular reaction dynamics [Wollenhaupt et al., J. Photochem. Photobiol. A: Chem., 2006, 180, 248].
Bergmann, Brixner, de Vivie-Riedle, Gaubatz, Geppert, Gollub, Hartmann, Kling, Kosloff, Krausz, Manz, Markus Kowalewski, Netz, Palao, Philipp von den Hoff, Rabitz, Regina de Vivie-Riedle, Sleva, Somloi, Sundermann, Sussman, Tannor, Tesch, Tesch, von den Hoff, von den Hoff, Wollenhaupt, Wollenhaupt, Wollenhaupt, Wollenhaupt, Wollenhaupt, Zhu, Zhu, Znakovskaya   +33 more
core   +1 more source

The Alternative Choice of Constitutive Exons throughout Evolution [PDF]

, 2007
Alternative cassette exons are known to originate from two processes exonization of intronic sequences and exon shuffling. Herein, we suggest an additional mechanism by which constitutively spliced exons become alternative cassette exons during evolution.
Adi Doron-Faigenboim, Amir Goren, Eddo Kim, Galit Lev-Maor, Gil Ast, Hadas Keren, Lisa Stubbs, Noa Sela, Shelly Leibman-Barak, Tal Pupko   +9 more
core   +5 more sources

Roles of Candida albicans Mig1 and Mig2 in glucose repression, pathogenicity traits, and SNF1 essentiality. [PDF]

, 2020
Metabolic adaptation is linked to the ability of the opportunistic pathogen Candida albicans to colonize and cause infection in diverse host tissues. One way that C.
Filler, Scott G, Huang, Manning Y, Lagree, Katherine, May, Gemma, McManus, C Joel, Mitchell, Aaron P, Solis, Norma V, Woolford, Carol A   +7 more
core   +3 more sources

Alternative Pathway Involvement in Protoporphyria Patients Related to Sun Exposure

Frontiers in Immunology, 2021
The homeostasis of tissues in a chronic disease is an essential function of the alternative pathway (AP) of the complement system (CS). However, if not controlled, it may also be detrimental to healthy cells with a consequent aggravation of symptoms. The
Francesca Granata, Lorena Duca, Valentina Brancaleoni, Silvia Fustinoni, Silvia Fustinoni, Giacomo De Luca, Irene Motta, Irene Motta, Giovanna Graziadei, Elena Di Pierro   +9 more
doaj   +1 more source

Alternative pathway androgen biosynthesis and human fetal female virilization

Proceedings of the National Academy of Sciences of the United States of America, 2019
Significance In the classic androgen biosynthesis pathway, testosterone is converted to 5α-dihydrotestosterone, a step crucially required for normal male genital virilization.
N. Reisch, A. Taylor, E. Nogueira, D. Asby, V. Dhir, Andrew A. Berry, N. Krone, R. Auchus, C. Shackleton, N. Hanley, W. Arlt   +10 more
semanticscholar   +1 more source

Decreased Ficolin-3-mediated Complement Lectin Pathway Activation and Alternative Pathway Amplification During Bacterial Infections in Patients With Type 2 Diabetes Mellitus

Frontiers in Immunology, 2019
Bacterial infections are frequent and severe in patients with diabetes mellitus. Whether diabetes per se induces functional alterations in the complement system hampering activation during infection is unknown.
László József Barkai, Emese Sipter, Dorottya Csuka, Zoltán Prohászka, Katrine Pilely, Peter Garred, Nóra Hosszúfalusi   +6 more
doaj   +1 more source

Structure-Guided Engineering of a Complement Component C3-Binding Nanobody Improves Specificity and Adds Cofactor Activity

Frontiers in Immunology, 2022
The complement system is a part of the innate immune system, where it labels intruding pathogens as well as dying host cells for clearance. If complement regulation is compromised, the system may contribute to pathogenesis.
Henrik Pedersen, Rasmus Kjeldsen Jensen, Annette Gudmann Hansen, Steen Vang Petersen, Steffen Thiel, Nick Stub Laursen, Nick Stub Laursen, Gregers Rom Andersen   +7 more
doaj   +1 more source

Role of Pneumococcal NanA Neuraminidase Activity in Peripheral Blood

Frontiers in Cellular and Infection Microbiology, 2019
The most frequent form of hemolytic-uremic syndrome (HUS) is associated with infections caused by Shiga-like toxin-producing Enterohaemorrhagic Escherichia coli (STEC). In rarer cases HUS can be triggered by Streptococcus pneumoniae.
Shahan Syed, Pipsa Hakala, Anirudh K. Singh, Anirudh K. Singh, Helena A. K. Lapatto, Samantha J. King, Samantha J. King, Seppo Meri, T. Sakari Jokiranta, T. Sakari Jokiranta, Karita Haapasalo   +10 more
doaj   +1 more source

Narrative-based computational modelling of the Gp130/JAK/STAT signalling pathway. [PDF]

, 2008
BACKGROUND: Appropriately formulated quantitative computational models can support researchers in understanding the dynamic behaviour of biological pathways and support hypothesis formulation and selection by "in silico" experimentation.
A Herrmann, A Mahdavi, A Regev, A Regev, A Singh, A Verma, AD Sharrocks, Anna Dudka, B Alberts, C Priami, C Priami, Corrado Priami, D Gillespie, F Ciocchetta, I Lödige, I Swameye, J Bravo, J Fisher, J Heath, J ten Hoeve, John K Heath, K Rakesh, L Dematté, L Dematté, L Klampfer, M Calder, M Kwiatkowska, Maria Luisa Guerriero, ML Guerriero, ML Guerriero, ML Guerriero, N Underhill-Day, NC Reich, Nicholas Underhill-Day, P Heinrich, S Bhattacharya, T Yamamoto, WS Alexander   +37 more
core   +7 more sources

Germline mutations in the alternative pathway of complement predispose to HELLP syndrome.

JCI Insight, 2018
BACKGROUND HELLP (hemolysis, elevated liver enzymes, and low platelets) syndrome is a severe variant of hypertensive disorders of pregnancy affecting approximately 1% of all pregnancies, and has significant maternal and fetal morbidity.
A. Vaught, Evan M. Braunstein, Jagar A. Jasem, Xuan Yuan, I. Makhlin, Solange N. Eloundou, Andrea C. Baines, Samuel A. Merrill, Shruti Chaturvedi, K. Blakemore, C. John Sperati, Robert A. Brodsky   +11 more
semanticscholar   +1 more source