Results 31 to 40 of about 6,006,467 (356)

Missing Linkers: An Alternative Pathway to UiO-66 Electronic Structure Engineering

Chemistry of Materials, 2017
UiO-66 is a promising metal–organic framework for photocatalytic applications. However, the ligand-to-metal charge transfer of an excited electron is inefficient in the pristine material.
Arthur De Vos, K. Hendrickx, P. Van der Voort, V. Van Speybroeck, K. Lejaeghere   +4 more
semanticscholar   +1 more source

Targeting the alternative bile acid synthetic pathway for metabolic diseases

Protein & Cell, 2020
The gut microbiota is profoundly involved in glucose and lipid metabolism, in part by regulating bile acid (BA) metabolism and affecting multiple BA-receptor signaling pathways.
Wei Jia, Meilin Wei, C. Rajani, Xiaojiao Zheng   +3 more
semanticscholar   +1 more source

The Alternative Complement Pathway Is Activated Without a Corresponding Terminal Pathway Activation in Patients With Heart Failure

Frontiers in Immunology, 2021
ObjectiveDysregulation of the complement system has been described in patients with heart failure (HF). However, data on the alternative pathway are scarce and it is unknown if levels of factor B (FB) and the C3 convertase C3bBbP are elevated in these ...
Margrethe Flesvig Holt, Margrethe Flesvig Holt, Annika E. Michelsen, Annika E. Michelsen, Negar Shahini, Elisabeth Bjørkelund, Christina Holt Bendz, Richard J. Massey, Richard J. Massey, Camilla Schjalm, Bente Halvorsen, Bente Halvorsen, Kaspar Broch, Kaspar Broch, Thor Ueland, Thor Ueland, Thor Ueland, Lars Gullestad, Lars Gullestad, Lars Gullestad, Per H. Nilsson, Per H. Nilsson, Pål Aukrust, Pål Aukrust, Pål Aukrust, Tom Eirik Mollnes, Tom Eirik Mollnes, Tom Eirik Mollnes, Tom Eirik Mollnes, Mieke C. Louwe   +29 more
doaj   +1 more source

Alternative Pathway Is Essential for Glomerular Complement Activation and Proteinuria in a Mouse Model of Membranous Nephropathy

Frontiers in Immunology, 2018
Membranous nephropathy is an immune kidney disease caused by IgG antibodies that form glomerular subepithelial immune complexes. Proteinuria is mediated by complement activation, as a result of podocyte injury by C5b-9, but the role of specific ...
Wentian Luo, F. Olaru, J. Miner, L. Beck, J. van der Vlag, J. Thurman, D. Borza   +6 more
semanticscholar   +1 more source

Small-molecule factor D inhibitors selectively block the alternative pathway of complement in paroxysmal nocturnal hemoglobinuria and atypical hemolytic uremic syndrome

Haematologica, 2016
Paroxysmal nocturnal hemoglobinuria and atypical hemolytic uremic syndrome are diseases of excess activation of the alternative pathway of complement that are treated with eculizumab, a humanized monoclonal antibody against the terminal complement ...
Xuan Yuan, E. Gavriilaki, J. Thanassi, Guangwei Yang, Andrea C. Baines, S. Podos, Yongqing Huang, Mingjun Huang, R. Brodsky   +8 more
semanticscholar   +1 more source

Mitochondrial Alternative Pathway-Associated Photoprotection of Photosystem II is Related to the Photorespiratory Pathway.

Plant and Cell Physiology, 2016
Respiratory electron transport has two ubiquinol-oxidizing pathways, the cytochrome pathway (CP) and the alternative pathway (AP). The AP, which is catalyzed by the alternative oxidase (AOX), is energetically wasteful but may alleviate PSII ...
C. Watanabe, W. Yamori, S. Takahashi, I. Terashima, K. Noguchi   +4 more
semanticscholar   +1 more source

Complement-coagulation cross-talk: a potential mediator of the physiological activation of complement by low pH

Frontiers in Immunology, 2015
The complement system is a major constituent of the innate immune system. It not only bridges innate and adaptive arms of the immune system but also links the immune system with the coagulation system.
Hany Ibrahim Kenawy, Ismet eBoral, Alan eBevington   +2 more
doaj   +1 more source

Quantitative Modeling of the Alternative Pathway of the Complement System

PLoS ONE, 2016
The complement system is an integral part of innate immunity that detects and eliminates invading pathogens through a cascade of reactions. The destructive effects of the complement activation on host cells are inhibited through versatile regulators that
Nehemiah T. Zewde, R. Gorham, Angel Dorado, D. Morikis   +3 more
semanticscholar   +1 more source

The Sez6 Family Inhibits Complement by Facilitating Factor I Cleavage of C3b and Accelerating the Decay of C3 Convertases

Frontiers in Immunology, 2021
The Sez6 family consists of Sez6, Sez6L, and Sez6L2. Its members are expressed throughout the brain and have been shown to influence synapse numbers and dendritic morphology. They are also linked to various neurological and psychiatric disorders.
Wen Q. Qiu, Shaopeiwen Luo, Stefanie A. Ma, Priyanka Saminathan, Herman Li, Jenny M. Gunnersen, Harris A. Gelbard, Jennetta W. Hammond   +7 more
doaj   +1 more source

Proprotein Convertases and the Complement System

Frontiers in Immunology, 2022
Proteins destined for secretion - after removal of the signal sequence - often undergo further proteolytic processing by proprotein convertases (PCs).
József Dobó, Andrea Kocsis, Ráhel Dani, Péter Gál   +3 more
doaj   +1 more source