Results 41 to 50 of about 7,204,743 (394)

An Oncogenic Role for Alternative NF-κB Signaling in DLBCL Revealed upon Deregulated BCL6 Expression [PDF]

, 2009
SummaryDiffuse large B cell lymphoma (DLBCL) is a complex disease comprising diverse subtypes and genetic profiles. Possibly because of the prevalence of genetic alterations activating canonical NF-κB activity, a role for oncogenic lesions that activate ...
Alizadeh, Annunziata, Basso, Bidère, Brown, Calado, Casola, Cattoretti, Choi, Compagno, Davis, Davis, Fabre, Gardam, Grumont, Häcker, Hans, He, Iqbal, Kato, Keats, Klein, Lenz, Lenz, Mandelbaum, Martins, Monti, Moore, Morin, Neri, Ngo, O’Mahony, Ohinata, Pasqualucci, Pasqualucci, Pham, Rossi, Saito, Sasaki, Sasaki, Sciammas, Shaffer, Srinivas, Staudt, Tam, Traenckner, Tunyaplin, Wright, Ye   +48 more
core   +3 more sources

Nitrogen deprivation induces cross-tolerance of Poa annua callus to salt stress

Biologia Plantarum, 2016
Alternative respiration pathway (AP) is an important pathway which can be induced by environment stresses in plants. In the present study, we show a new mechanism involving the AP in nitrogen deprivation-induced tolerance of Poa annua callus to salt ...
C. Z. Zhao, P. Li, X. M. Wang, P. Li, X. Y. Wang, F. Wang, J. F. Wang, N. Chang, Y. R. Bi   +8 more
doaj   +1 more source

The role of the alternative pathway of complement activation in glomerular diseases

Clinical and Experimental Medicine (Testo stampato), 2018
The complement system (CS) has recently been recognized as a bridge between innate and adaptive immunity that constitutes a very complex mechanism controlling the clearance of pathogens, cellular debris, and immune complexes.
Emilia Łukawska, M. Polcyn-Adamczak, Z. Niemir   +2 more
semanticscholar   +1 more source

Serine biosynthesis with one carbon catabolism represents a novel pathway for ATP generation in cells using alternative glycolysis with zero net ATP production [PDF]

, 2011
Recent experimental evidence indicates that some cancer cells have an alternative glycolysis pathway with net zero ATP production, implying that upregulation of glycolysis in these cells may not be related to the generation of ATP.
Alexei Vazquez, Elke K. Markert, Zoltan N. Oltvai   +2 more
core   +2 more sources

Self-Damage Caused by Dysregulation of the Complement Alternative Pathway: Relevance of the Factor H Protein Family

Frontiers in Immunology, 2018
The alternative pathway is a continuously active surveillance arm of the complement system, and it can also enhance complement activation initiated by the classical and the lectin pathways.
P. Sánchez-Corral, R. Pouw, M. López-Trascasa, M. Józsi   +3 more
semanticscholar   +1 more source

Systematic Review of the Link Between Oxford MEST-C Classification and Complement Activation in IgA Nephropathy

Kidney International Reports
Introduction: IgA nephropathy's (IgAN’s) MEST-C classification relationship with complement activation is still not fully understood because of limited and conflicting evidence.
Gabriel Ștefan, Eric Alamartine, Christophe Mariat, Nicolas Maillard   +3 more
doaj   +1 more source

Targeting the alternative bile acid synthetic pathway for metabolic diseases

Protein & Cell, 2020
The gut microbiota is profoundly involved in glucose and lipid metabolism, in part by regulating bile acid (BA) metabolism and affecting multiple BA-receptor signaling pathways.
Wei Jia, Meilin Wei, C. Rajani, Xiaojiao Zheng   +3 more
semanticscholar   +1 more source

Calcium signalling links MYC to NUAK1 [PDF]

, 2018
NUAK1 is a member of the AMPK-related family of kinases. Recent evidence suggests that NUAK1 is an important regulator of cell adhesion and migration, cellular and organismal metabolism, and regulation of TAU stability.
Hedley, A,, Knight, J.R., Monteverde, T., Murphy, D.J., Sansom, O.J., Tait-Mulder, J.   +5 more
core   +1 more source

Isoprene oxidation by the gram-negative model bacterium variovorax sp. WS11 [PDF]

, 2020
Plant-produced isoprene (2-methyl-1,3-butadiene) represents a significant portion of global volatile organic compound production, equaled only by methane.
Crombie, Andrew T., Dawson, Robin A., Larke-Mejía, Nasmille L., Murrell, J. Colin, Ul Haque, Muhammad Farhan   +4 more
core   +1 more source

A potent complement factor C3–specific nanobody inhibiting multiple functions in the alternative pathway of human and murine complement

Journal of Biological Chemistry, 2018
The complement system is a complex, carefully regulated proteolytic cascade for which suppression of aberrant activation is of increasing clinical relevance, and inhibition of the complement alternative pathway is a subject of intense research.
R. K. Jensen, Rasmus Pihl, T. Gadeberg, J. Jensen, K. R. Andersen, S. Thiel, N. S. Laursen, G. Andersen   +7 more
semanticscholar   +1 more source