Calcium signalling links MYC to NUAK1 [PDF]
NUAK1 is a member of the AMPK-related family of kinases. Recent evidence suggests that NUAK1 is an important regulator of cell adhesion and migration, cellular and organismal metabolism, and regulation of TAU stability.
Hedley, A,+5 more
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Alternative Excision Repair Pathways [PDF]
Alternative excision repair (AER) is a category of excision repair initiated by a single nick, made by an endonuclease, near the site of DNA damage, and followed by excision of the damaged DNA, repair synthesis, and ligation. The ultraviolet (UV) damage endonuclease in fungi and bacteria introduces a nick immediately 5' to various types of UV damage ...
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The Lectin Pathway of Complement Activation Is a Critical Component of the Innate Immune Response to Pneumococcal Infection [PDF]
The complement system plays a key role in host defense against pneumococcal infection. Three different pathways, the classical, alternative and lectin pathways, mediate complement activation.
Ali, Youssif M.+15 more
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Utilizing the Boston Syncope Observation Management Pathway to Reduce Hospital Admission and Decrease Adverse Outcomes [PDF]
Introduction: In an age of increasing scrutiny of each hospital admission, emergency department (ED) observation has been identified as a low-cost alternative. Prior studies have shown admission rates for syncope in the United States to be as high as 70%.
Grossman, Shamai A.+7 more
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Production of FAME biodiesel in E. coli by direct methylation with an insect enzyme. [PDF]
Most biodiesel currently in use consists of fatty acid methyl esters (FAMEs) produced by transesterification of plant oils with methanol. To reduce competition with food supplies, it would be desirable to directly produce biodiesel in microorganisms.
Bowie, James U+3 more
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The arogenate dehydratase ADT2 is essential for seed development in Arabidopsis [PDF]
Phenylalanine (Phe) biosynthesis in plants is a key process, as Phe serves as precursor of proteins and phenylpropanoids. The prephenate pathway connects chorismate, final product of the shikimate pathway, with the biosynthesis of Phe and Tyr.
Canovas-Ramos, Francisco Miguel+3 more
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Alternative final steps in berberine biosynthesis in Coptis japonica cell cultures [PDF]
In Coptis japonica cell cultures an alternative pathway has been discovered which leads from (S)-tetrahydrocolumbamine via (S)-canadine to berberine. The two enzymes involved have been partially purified.
Galneder, E.+4 more
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The dynamics of alternative pathways to compensatory substitution [PDF]
17 pages, 9 figures, 1 table.
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Identification and characterization of an inhibitory fibroblast growth factor receptor 2 (FGFR2) molecule, up-regulated in an Apert Syndrome mouse model [PDF]
AS (Apert syndrome) is a congenital disease composed of skeletal, visceral and neural abnormalities, caused by dominant-acting mutations in FGFR2 [FGF (fibroblast growth factor) receptor 2].
Anderson+57 more
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Prioritising the best use of biomass resources: conceptualising trade-offs [PDF]
02.09.13 KB. Ok to add report to Spiral. Authors hold copyrightUsing biomass to provide energy services is one of the most versatile options for increasing the proportion of renewable energy in the existing system.
Bauen, A, Gross, R, Slade, R
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