Results 161 to 170 of about 12,502 (214)
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Leishmania amazonensis: Acidic organelles in amastigotes
Experimental Parasitology, 1988Leishmania amastigotes are intracellular protozoan parasites which exclusively invade cells of the macrophage series and multiply within phagolysosomes. Recent studies showed that intracellular and isolated amastigotes of L. amazonesis are killed by amino acid esters which appear to be trapped within as yet unidentified, possibly acidified, "lysosome ...
J C, Antoine +3 more
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International Journal of Antimicrobial Agents, 2007 The in vitro antileishmanial activities of various new amphotericin B (AMB) formulations were investigated, including microspheres of hydrophilic albumin with three AMB aggregation forms (monomeric, dimeric and multiaggregate) and the polymers of ...
José Maria Alunda +2 more
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Respiration of Leishmania mexicana amastigotes and promastigotes
Molecular and Biochemical Parasitology, 1981Promastigotes of Leishmania mexicana mexicana recently derived from amastigotes by transformation in vitro respired at a rate (17 nmol O2/min per 10(8) parasites) 4-5 times higher than that of amastigotes, but when the difference in cell protein content between the two preparations was taken into account the rates were not significantly different (32 ...
D T, Hart, K, Vickerman, G H, Coombs
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Living in a phagolysosome; metabolism of Leishmania amastigotes
Trends in Parasitology, 2007Leishmania amastigotes primarily proliferate within macrophages in the mammalian host. Genome-based metabolic reconstructions, combined with biochemical, reverse genetic and mRNA or protein profiling studies are providing new insights into the metabolism of this intracellular stage.
Malcolm J, McConville +4 more
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Roles of free GPIs in amastigotes of Leishmania
Molecular and Biochemical Parasitology, 1999Glycosylated phosphatidylinositols (GPIs) are abundant cell surface molecules of the Leishmania. Amastigote-specific GPIs AmGPI-Y and AmGPI-Z, both ethanolamine (EtN)-containing glycolipids, were identified in Leishmania amazonensis. A paucity of GPI-anchored proteins in amastigotes of L.
K, Mensa-Wilmot +7 more
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An amastigote phase of the sleeping sickness trypanosome
Transactions of the Royal Society of Tropical Medicine and Hygiene, 1971Abstract 1. 1. We have found amastigotes closely packed together with “white thrombus” in capillaries, in sections of the choroid plexus of rats which had been infected with a strain of Trypanosoma brucei isolated from man in Botswana. 2. 2.
W E, Ormerod, S, Venkatesan
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Experimental Parasitology, 1984
Leishmania mexicana mexicana promastigotes, axenic amastigotes, and amastigotes derived from Vero cells were examined for de novo purine synthesis and mechanisms of purine salvage. Both promastigotes and axenic amastigotes were incapable of de novo purine synthesis, as shown by the lack of [14C]formate and [14C]glycine incorporation into purine ...
B D, Hansen +3 more
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Leishmania mexicana mexicana promastigotes, axenic amastigotes, and amastigotes derived from Vero cells were examined for de novo purine synthesis and mechanisms of purine salvage. Both promastigotes and axenic amastigotes were incapable of de novo purine synthesis, as shown by the lack of [14C]formate and [14C]glycine incorporation into purine ...
B D, Hansen +3 more
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Axenic culture of Leishmania Amastigotes
Parasitology Today, 1993One of the future goals in Leishmania research will be to reproduce the entire life cycle oxenically, in vitro. In this article, Paul Bates reviews recent progress in the axenic culture of amastigotes and addresses some of the remaining problems associated with culture methods for both amostigote and promostigote forms.
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Reconstruction of the Chondriome of the Amastigote Form of Trypanosoma cruzi
The Journal of Parasitology, 1989The chondriome of the amastigote form of Trypanosoma cruzi was studied by fluorescent microscopy using rhodamine 123 and conventional transmission electron microscopy of serial thick sections. The 3-dimensional models of the chondriome generated from the serial sections using manual or computer-assisted analysis revealed a single circular or horseshoe ...
L B, Newberry, J J, Paulin
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Mathematical morphology for counting Trypanosoma cruzi amastigotes
2013 XXXIX Latin American Computing Conference (CLEI), 2013The hemoflagellate protozoan parasite Trypanosoma cruzi is the causative agent of the Chagas disease. The two drugs used clinically have a high level of toxicity and are active only during the acute phase of the disease, making it urgent the development of new safe and effective treatment. The first step in the screening of new compounds is to identify
Jose Luis Vazquez Noguera +3 more
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