Results 51 to 60 of about 11,756 (178)

A role for extracellular amastigotes in the immunopathology of Chagas disease [PDF]

Memórias do Instituto Oswaldo Cruz, 1999
In spite of the growing knowledge obtained about immune control of Trypanosoma cruzi infection, the mechanisms responsible for the variable clinico-pathological expression of Chagas disease remain unknown. In a twist from previous concepts, recent studies indicated that tissue parasitism is a pre-requisite for the development of chronic myocarditis ...
Julio Scharfstein, Alexandre Morrot
openaire   +4 more sources

An Unusual Presentation of Cutaneous Leishmaniasis in a Patient with Substance Use: A Diagnostic and Management Case Report

Clinical Case Reports, Volume 14, Issue 5, May 2026.
ABSTRACT In patients with atypical ulcers and travel history to endemic areas, a comprehensive diagnostic workup for cutaneous leishmaniasis is imperative. This case confirms Leishmania tropica through combined microscopy, culture, and PCR, leading to successful treatment with systemic glucantime and adjunctive wound care.
Hossein Pazoki, Eissa Soleymani, Shirafkan Kordi, Mahdi Fakhar   +3 more
wiley   +1 more source

In vitro efficacy of Coriandrum sativum, Lippia sidoides and Copaifera reticulata against Leishmania chagasi Eficácia in vitro de Coriandrum sativum, Lippia sidoides e Copaifera reticulata sobre Leishmania chagasi

Revista Brasileira de Parasitologia Veterinária, 2012
The increased incidence of visceral leishmaniasis (VL) in Brazil is due to a lack of effective disease control measures. In addition to that, no effective treatment exists for canine VL in response to synthetic drugs.
Fernanda Cristina Macedo Rondon, Claudia Maria Leal Bevilaqua, Marina Parissi Accioly, Selene Maia de Morais, Heitor Franco de Andrade-Júnior, Camila Aparecida de Carvalho, Josemar Coelho Lima, Hilton César Rodrigues Magalhães   +7 more
doaj   +1 more source

Structural basis of secreted acid phosphatase polymerization in the Leishmania parasite

Protein Science, Volume 35, Issue 5, May 2026.
Abstract Enzymes that assemble into filaments typically transition between protomeric and polymeric states in response to cellular conditions. In contrast, the secreted acid phosphatase (SAP) of Leishmania, one of the most abundant extracellular glycoproteins produced by the parasite and regarded as a major virulence factor in the neglected tropical ...
Priyanka Bose, Irit Dahan, Alexander Upcher, Ran Zalk, Iris Grossman‐Haham   +4 more
wiley   +1 more source

IFN-γ plays a unique role in protection against low virulent Trypanosoma cruzi strain. [PDF]

PLoS Neglected Tropical Diseases, 2012
BACKGROUND: T. cruzi strains have been divided into six discrete typing units (DTUs) according to their genetic background. These groups are designated T. cruzi I to VI. In this context, amastigotes from G strain (T.
Adele A Rodrigues, Jasson S S Saosa, Grace K da Silva, Flávia A Martins, Aline A da Silva, Cecílio P da Silva Souza Neto, Catarina V Horta, Dario S Zamboni, João S da Silva, Eloisa A V Ferro, Claudio V da Silva   +10 more
doaj   +1 more source

In Vitro Evaluation of Antileishmanial Activity of Commiphora myrrha Essential Oil Nanoliposome

Veterinary Medicine and Science, Volume 12, Issue 3, May 2026.
This study investigates the efficacy of nanoliposomal formulations containing myrrh essential oil in combating Leishmania protozoa in laboratory settings. Myrrh essential oil and nanoliposomes were prepared in RPMI‐1640 medium at concentrations of 1, 2, 5 and 10 µg/dL.
Zahra Akbari, Mohammad Reza Youssefi, Mohaddeseh Abouhosseini Tabari   +2 more
wiley   +1 more source

Elimination of Leishmania donovani amastigotes by activated macrophages [PDF]

Infection and Immunity, 1981
Tissue macrophages are the obligatory host cells for Leishmania donovani, the causative agent of visceral leishmaniasis. In this study we sought to determine whether activated macrophages, as defined by the functional criterion of tumor cell cytotoxicity, were also able to exert a microbicidal effect on ingested L. donovani amastigotes.
C G, Haidaris, P F, Bonventre
openaire   +2 more sources

Successful Management of Septic Splenitis in an Abyssinian Cat

Veterinary Medicine and Science, Volume 12, Issue 3, May 2026.
A 3.5‐year‐old female neutered Abyssinian with pyrexia of unknown origin and splenomegaly was diagnosed with septic splenitis. Complete resolution of clinical signs followed splenectomy and antibiotic treatment with pradofloxacin. Septic splenitis, although uncommon, should be considered as a differential diagnosis in patients with splenomegaly and ...
Martina Vecín Sancho, Perrine Henry, Mica Taylor, Catherine Davidson, María Lázaro Muñoz, Efa Llewellyn, Maša Vilfan, Paola Cazzini, Linda Morrison, Kelly Blacklock, Danièlle Gunn‐Moore   +10 more
wiley   +1 more source

Production of amastigotes from metacyclic trypomastigotes of Trypanosoma cruzi

Memorias do Instituto Oswaldo Cruz, 2002
Attempts to recreate all the developmental stages of Trypanosoma cruzi in vitro have thus far been met with partial success. It is possible, for instance, to produce trypomastigotes in tissue culture and to obtain metacyclic trypomastigotes in axenic ...
Víctor T Contreras, María C Navarro, Ana R De Lima, Rosa Arteaga, Francy Duran, José Askue, Yunaimy Franco   +6 more
doaj   +1 more source

Tegumentary Leishmaniasis Associated With Immune Reconstitution in an HIV Patient—A Case Report

Parasite Immunology, Volume 48, Issue 5, May 2026.
ABSTRACT HIV‐associated Immune Reconstitution Inflammatory Syndrome (IRIS) may significantly alter the immunopathological presentation of American Tegumentary Leishmaniasis (ATL), occasionally causing paradoxical clinical exacerbations. We report the long‐term follow‐up of a 39‐year‐old female coinfected with HIV and disseminated mucocutaneous ...
Marilia Brasil Xavier, Claudia Maria de Castro Gomes, Rita Catarina Medeiros Sousa, Edna Aoba Yassui Ishikawa, Elza Baía de Brito, Silvia Ferreira Rodrigues Müller, Lucas dos Santos Fontes, João Augusto Gomes de Souza Monteiro de Brito, Larissa dos Santos Alcantara, Carlos Eduardo Pereira Corbett   +9 more
wiley   +1 more source