Results 1 to 10 of about 60,987 (128)
Overexpression of Serotonin N-Acetyltransferase Cloned from the Green Algae Chara braunii Confers Peroxidizing Herbicide Tolerance Through the Induction of Protoporphyrinogen Oxidase 1 in Rice [PDF]
AntioxidantsSerotonin N-acetyltransferase (SNAT) is pivotal to melatonin biosynthesis, catalyzing either serotonin into N-acetylserotonin or 5-methoxytryptamine (5-MT) into melatonin. Many SNAT genes have been cloned from a wide range of organisms, including animals
Kyungjin Lee, Kyoungwhan Back
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Polyamine metabolic enzyme SAT1 remodels the neuronal transcriptome and rescues α-synuclein toxicity in Drosophila [PDF]
Amino AcidsPolyamine homeostasis is tightly regulated by interconversion and catabolic pathways and has been increasingly implicated in neurodegenerative disorders, including Parkinson’s disease (PD), where accumulation of α-synuclein (α-Syn) perturbs neuronal ...
Zoya R. Bangash +5 more
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NAT10 and ac4C modification in cancer immunity and metabolism: emerging mechanisms and therapeutic potential [PDF]
Journal of Translational MedicineBackground Tumor immunity and metabolism are interconnected through the tumor microenvironment (TME), with RNA modifications playing pivotal epigenetic regulatory roles.
Yanqi Yang +3 more
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Biomolecules, 2023 Serotonin N-acetyltransferase (SNAT) functions as the penultimate or final enzyme in melatonin biosynthesis, depending on the substrate. The Escherichia coli orthologue of archaeal SNAT from Thermoplasma volcanium was identified as RimI (EcRimI), with 42%
Kyungjin Lee, Kyoungwhan Back
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Identification of amino acid residues essential for the yeast N-acetyltransferase Mpr1 activity by site-directed mutagenesis. [PDF]
FEMS yeast research, 2008 We previously discovered that the budding yeast Saccharomyces cerevisiae Sigma1278b has the MPR1 gene that confers resistance to the proline analogue azetidine-2-carboxylate (AZC). The MPR1-encoded protein (Mpr1) is an N-acetyltransferase that detoxifies AZC and is a novel member of the GCN5-related N-acetyltransferase (GNAT) superfamily.
Tetsuya, Kotani, Hiroshi, Takagi
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Crystal structure of Helicobacter pylori pseudaminic acid biosynthesis N-acetyltransferase PseH: implications for substrate specificity and catalysis. [PDF]
PLoS ONE, 2015 Helicobacter pylori infection is the common cause of gastroduodenal diseases linked to a higher risk of the development of gastric cancer. Persistent infection requires functional flagella that are heavily glycosylated with 5,7-diacetamido-3,5,7,9 ...
Abu I Ud-Din +2 more
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Scientific Reports, 2021 N-acetyltransferase 10 (NAT10), is an acetyltransferase that regulates RNA stability and translation processes. Association of NAT10 with several diseases including cancer, makes it a promising therapeutic target.
Mahmood Hassan Dalhat +3 more
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Insects, 2021 Melatonin is synthesized from the amino acid L-tryptophan via the shikimic acid pathway and ubiquitously distributed in both prokaryotes and eukaryotes. Although most of melatonin biosynthesis genes were characterized in several plants and animal species
Yasser Nehela, Nabil Killiny
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Проблемы особо опасных инфекций, 2022 The aim of the study was to identify and compare potential determinants of aminoglycoside resistance in gentamicin susceptible Burkholderia pseudomallei strains.Materials and methods. A bioinformatics analysis of whole genome shotgun sequences of three B.
P. R. Chirskov +4 more
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Frontiers in Microbiology, 2023 BackgroundAeromonas species have been identified as agents responsible for various diseases in both humans and animals. Multidrug-resistant Aeromonas strains pose a significant public health threat due to their emergence and spread in clinical settings ...
Guozhi Zhang +22 more
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