Results 171 to 180 of about 15,918,440 (250)

Disruption of cysteine metabolism leads to synthetic lethality and <i>in vivo</i> fitness impairment in <i>Acinetobacter baumannii</i>. [PDF]

mBio
Pathak A, Saini S, Pathania R.
europepmc   +1 more source

PEAR1 Promotes Glucose Metabolism Reprogramming in Sepsis‐Associated Acute Lung Injury via AARS1‐Mediated HIF‐1α Lactylation

Advanced Science, Volume 13, Issue 56, 9 October 2026.
This study revealed that a PEAR1/HIF‐1α/ glycolysis/lactate/H3K18la positive feedback loop in PMVECs that drives the development of S‐ALI. Mechanistically, PEAR1 mediates the binding of HIF‐1α to AARS1, leading to the lactylation of HIF‐1α, the primary lactylation site of which is K172.
Shuai Li, Zongqing Lu, Pu Fang, Qingqing Pang, Xianghui Wu, Bo Wang, Min Liang, Jingjing Pan, Haobo Kong, Haijian Cai, Juanjuan Li, Jiaying Kang, Dongsheng Wang, Dunling Xia, Mengmeng Xu, Qinghai You   +15 more
wiley   +1 more source

Functional and metabolomic analyses of brown adipose tissue during cold-deacclimation reveal rapid N-acetylated amino acid adaptations. [PDF]

iScience
Pileggi CA, McIlroy E, Hamilton LMK, Kuksal N, Kennedy LS, Vasilyeva V, Kanaan MN, El Hankouri Z, Burelle Y, Cuperlovic-Culf M, Harper ME.   +10 more
europepmc   +1 more source

Ketogenic Diet–Associated Remodeling of the Cortical Proteome in Rats With Genetic Absence Epilepsy

Brain and Behavior, Volume 16, Issue 10, October 2026.
Proteomic profiling of the somatosensory cortex revealed that ketogenic diet was associated with remodeling of cortical protein networks in GAERS absence epilepsy, with altered proteins enriched in synaptic and mitochondrial pathways. ABSTRACT Purpose This study investigated the effects of ketogenic diet (KD) intervention on the cortical proteome in ...
Aslihan Gunel, Ulku Guler, Aylin Toplu, Nazli Busra Acikgoz, Bora Onat, Ariorad Moniri, Bekir Salih, Osman Ugur Sezerman, Filiz Onat   +8 more
wiley   +1 more source

First Draft genome sequence of strain MF0224, representing an unclassified <i>Fusobacterium</i>-related lineage isolated from coastal sediments of Puducherry, India. [PDF]

Data Brief
Prathaban M, Prathiviraj R, Sobanaa M, Hari Krishna Kumar S, Vimala RTV, Seghal Kiran G, Selvin J, Dufossé L.   +7 more
europepmc   +1 more source

CCNE1: A Cell Cycle Regulator That Influences Tumor Progression

Cancer Medicine, Volume 15, Issue 10, October 2026.
ABSTRACTCyclin E1 (CCNE1), a pivotal member of the cyclin family, governs the G1/S phase transition of the cell cycle by binding to and activating cyclin‐dependent kinase 2 (CDK2), thereby initiating DNA replication and driving S‐phase entry. In a broad spectrum of human malignancies—including breast, ovarian, gastric, and non‐small cell lung cancers ...
Liang Yan, Siyi Liu, Yanling Li, Qian He, Chen Long, Ning Tang, Yanhong Zhou   +6 more
wiley   +1 more source

Full-spectrum cannabidiol-rich oil modulates behavior and neurochemical alterations in a rodent model of maple syrup urine disease. [PDF]

Metab Brain Dis
da Silva Lemos I, Duarte S, Morais MODS, Alano CG, Quinsani LS, Matiola RT, Niero FS, Pedro LC, Réus Z, Rigo FK, de Bitencourt RM, Streck EL.   +11 more
europepmc   +1 more source

Nicotinamide and Sodium Butyrate Double the Pool of Treatment‐Exclusive Metabolites in the Endophytic Fungus Curvularia sp. G6‐32

Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.
Epigenetic modulators nicotinamide and sodium butyrate reshape the chemical landscape of the endophytic fungus Curvularia sp. G6‐32. Combining the OSMAC strategy with UHPLC‐MS/MS metabolomics and molecular networking reveals a more than twofold rise in treatment‐exclusive metabolites, including diketopiperazines and potentially bioactive natural ...
Guilherme Edison Almeida Pega, Laís Stella Perassolli Nicchio, Andressa Domingos Polli, Francielli Alana Pereira Valeze, Évelin Lemos de Oliveira, Eduardo Cesar Meurer, Débora Cristina Baldoqui, João Lúcio Azevedo, Julio Cesar Polonio   +8 more
wiley   +1 more source

NAT10 promotes proliferation, invasion, and epithelial-mesenchymal transition in hepatocellular carcinoma through α-tubulin acetylation. [PDF]

Cell Adh Migr
Yu H, Zhu K, Zhang G, Dong Y, Wang X, Zhang S, Huang J, Lu X, Zhang X, Liu H, Chen W.   +10 more
europepmc   +1 more source

Mapping Mutations and Signaling Network Interactions to Guide Precision Therapy in Gallbladder Cancer

Cancer Reports, Volume 9, Issue 10, October 2026.
ABSTRACT Background Gallbladder cancer (GBC) is a biologically complex malignancy arising from the epithelial lining of the gallbladder, with adenocarcinoma constituting the major histological subtype. Early detection is challenging because of vague clinical manifestations and the organ's deep‐seated anatomical location, resulting in diagnosis at ...
Nisha Manav, Akanksha Kashyap, Lakshay Malhotra, Chethan Rajegowda, Chandra Prakash Prasad   +4 more
wiley   +1 more source