Results 181 to 190 of about 15,918,440 (250)

Tryptophan's Journey Through Pregnancy: The Role of Serotonin. [PDF]

Int J Tryptophan Res
Gendrot B, Vaillancourt C, Fouquet G.
europepmc   +1 more source

Clinical Function Assignment of NAT2 Alleles by the Clinical Pharmacogenetics Implementation Consortium Pharmacogene Curation Expert Panel

Clinical Pharmacology &Therapeutics, Volume 120, Issue 4, Page 1101-1110, October 2026.
NAT2 encodes arylamine N‐acetyltransferase 2, a key enzyme in the phase II metabolism of arylamines and arylhydrazines. NAT2 is highly polymorphic, resulting in variable distributions of rapid and poor metabolizers across global populations. Here, we detail the process undertaken by the Clinical Pharmacogenetics Implementation Consortium (CPIC) NAT2 ...
Bailey M. Tibben, David W. Hein, Michelle Whirl‐Carrillo, Andrea Gaedigk, Michael T. Eadon, Rodney F. Minchin, Sotiria Boukouvala, Adalberto Rezende Santos, Roseann S. Donnelly, José A. G. Agúndez, Kelly E. Caudle   +10 more
wiley   +1 more source

Histone deacetylases in cancer metabolic reprogramming. [PDF]

Exp Mol Med
Jeon YH, Seo H, Youn JW, Yoo J, Lee SW, Oh SY, Kwon SH.   +6 more
europepmc   +1 more source

Lactate metabolism and protein lactylation in programmed cell death: From novel mechanism to therapeutic strategies in human diseases

Clinical and Translational Medicine, Volume 16, Issue 10, October 2026.
This review highlights protein lactylation as a metabolic‐epigenetic regulator linking lactate reprogramming to programmed cell death. By modulating histone and non‐histone targets, lactylation reshapes cell fate decisions and represents a promising biomarker and therapeutic target in human diseases.
Yue Chen, Xiwen Wang, Xiuping Wang, Na Lin, Wenjie Wang, Ruiqi Fu, Yutong Wu, Yi Liu, Hengwei Liu   +8 more
wiley   +1 more source

Discovery of regulatory complexes in Arabidopsis via protein-metabolite mapping during Pseudomonas infection. [PDF]

Plant Physiol
Kang J, Sokolowska EM, Zillmer H, Karasov T, Walther D, Skirycz A.   +5 more
europepmc   +1 more source

Life‐History, Stress‐Resistance, and Transcriptomic Variation Among a Mexican Caenorhabditis elegans Isolate and Contemporary and Ancestral N2 Lineages

Ecology and Evolution, Volume 16, Issue 10, October 2026.
We compared a recently isolated wild strain of Caenorhabditis elegans from Mexico City (VJV2) with the contemporary standard N2 Lab strain and the cryopreserved N2 Ancestral lineage. The strains differed in lifespan, fertility, and survival under pathogen, oxidative, and heat stress.
Jaqueline Hersch‐González, Nallely Cano‐Domínguez, Mariana Zurita‐León, Francisco Pinta‐Castro, Maribel Soto‐Nava, Santiago Avila‐Rios, Victor Julian Valdes   +6 more
wiley   +1 more source

Evolutionary adaptations in iron capture via type II pyoverdine in XDR <i>Pseudomonas aeruginosa ST235</i>. [PDF]

Virulence
Vatansever C, Akpınar A, Kolsuz S, Özcan G, Ekinci G, Azap Ö, Kazar AE, Kahraman K, Ural E, Dağ Ç, Gönen M, Can F.   +11 more
europepmc   +1 more source

Citrus depressa peel extract and its polymethoxyflavones mitigate acetaminophen‐induced chronic liver injury in mice through antioxidant activation, epigenetic regulation, and gut microbiota modulation

Journal of the Science of Food and Agriculture, Volume 106, Issue 13, Page 7629-7642, October 2026.
Abstract BACKGROUND Preventing chronic liver damage is essential for maintaining overall health and reducing the risk of serious liver diseases. Acetaminophen (APAP) overdose can lead to severe liver damage due to oxidative stress, and citrus fruits are rich in bioactive compounds that may have health benefits.
Po‐Yao Tsai, Zi‐Han Lin, Guor‐Jien Wei, Liang‐Yi Wu, Tien‐Yuan Wu, Yen‐Chen Tung, Ssu‐Han Huang, Zheng‐Yuan Su   +7 more
wiley   +1 more source

Proteomic Insights into Antimicrobial Resistance Mechanisms in Human-Associated Bacterial Pathogens. [PDF]

Microb Ecol
Babele P, Singh P, Pant A, Chawla M, Das B.   +4 more
europepmc   +1 more source

Maturation‐Dependent Constraints in the Ability of Human Monocytes to Initiate Trained Immunity

MedComm, Volume 7, Issue 10, October 2026.
In premature infants, innate immune memory may serve as an important compensatory mechanism for the underdeveloped adaptive immune system. However, monocytes derived from prematurely born individuals display abnormal metabolic and insufficient transcriptomic responses to β‐glucan‐induced training.
Michael Eigenschink, Elsa Davogg, Manuel Pristner, David Seki, Marcus Arzmüller, Herbert Kiss, Alex Farr, Angelika Berger, David Berry, Benedikt Warth, Lukas Wisgrill   +10 more
wiley   +1 more source