Results 191 to 200 of about 15,918,440 (250)

Gentamicin and d-serine selective pressure to improve the homogeneity of cells expressing target proteins. [PDF]

Synth Syst Biotechnol
Gelain L, Yeoh JW, Au-Yeung BSY, Guillouet S, Poh CL, Gorret N, Foo JL.   +6 more
europepmc   +1 more source

Posttranslational Modifications of p62/SQSTM1 in Health and Disease

MedComm, Volume 7, Issue 10, October 2026.
Schematic illustration of p62 as a posttranslational modifications (PTMs)‐programmed integrator in homeostasis, pathogenesis, and therapeutic targeting. (Left) Homeostasis: In physiological states, p62, through various PTMs such as phosphorylation, ubiquitination, and acetylation, coordinates essential cellular functions.
Weikai Wang, Xin Jiang, Runing Qiu, Chandra Sugiarto Wijaya, Miaoqin Chen, Jin Wang, Liyuan Zhu, Hongchuan Jin, Lifeng Feng   +8 more
wiley   +1 more source

Crosstalk between cysteine and lysine modifications: Integrating redox and metabolic regulation. [PDF]

Redox Biol
Mitchem EC, Roede JR, Fritz KS.
europepmc   +1 more source

Brown Adipose Tissue: Molecular Mechanisms of Regulation, Physiological Functions, and Therapeutic Targets

MedComm, Volume 7, Issue 10, October 2026.
This review systematically covers three core dimensions of brown adipose tissue (BAT): multilayered regulatory mechanisms governing brown adipocyte differentiation and phenotypic identity, physiological functions and signaling pathways in mediating thermogenesis and systemic metabolic crosstalk between BAT and multiple organs, and emerging clinical in ...
Xiaoli Deng, Yuanyuan Shen, Ying Sun, Lu Lu, Chongkui Sun   +4 more
wiley   +1 more source

Antifungal resistance: from classical mechanisms to the expanding role of acetyltransferases. [PDF]

J Biomed Sci
Werneck SMC, Gouveia-Eufrasio L, de Freitas GJC, de Carvalho DS, da Costa César I, Rossato L, Bastos RW, Peres NTA, Santos DA.   +8 more
europepmc   +1 more source

Cytoskeletal Dynamics in Cancer: From Pathogenesis to Treatment

MedComm, Volume 7, Issue 10, October 2026.
This review systematically addresses the fundamental roles of the cytoskeleton (actin filaments, microtubules, and intermediate filaments) in cancer progression. We focus on how cytoskeletal dynamics regulate tumor proliferation, metastasis, and programmed cell death, while also modulating the immune microenvironment. Understanding these mechanisms may
Jie Chen, Wenxi Yang, Yonghan Song, Yuanhao Zhang, Jia Ma, Tingyao Wang, Jijun Zheng, Hebin Zhang, Yiyao Liu, Jinhao Zeng   +9 more
wiley   +1 more source

The roles of the acetyltransferase domains of the chromatin regulators KAT6A and KAT6B in vivo. [PDF]

Development
Thomas T, Malelang S, Yang Y, Bergamasco MI, Kueh AJ, Garnham AL, Ranathunga N, Smyth GK, Voss AK.   +8 more
europepmc   +1 more source

Iron and Other Metal Ions in Human Health and Disease

MedComm, Volume 7, Issue 10, October 2026.
Iron, copper, zinc, and calcium orchestrate cellular function through distinct yet cooperative mechanisms: redox‐active iron and copper cycle between oxidation states to act as Fenton catalysts and electron carriers in oxidative phosphorylation (OXPHOS); redox‐inert zinc serves as a structural component of zinc‐finger proteins and a catalytic cofactor ...
Xiaofeng Dai, Jitian Li
wiley   +1 more source

The RNA helicase domain of NAT10 promotes the biogenesis of hypomodified ribosomes to enhance cancer cell proliferation. [PDF]

Nat Commun
Dalhat MH, Narayan S, Eleftheriou M, Russell J, Heslop J, Serio H, Alzahrani KA, Suh A, Edakkara A, Raikundalia S, Landmann L, Asby R, Stamou E, López J, Malam Y, Aspris D, Patrasso EA, Mou S, Giotopoulos G, Khaled WT, Huntly BJP, Sampaziotis F, Tzelepis K, Arango D.   +23 more
europepmc   +1 more source

Muscarinic agonists for schizophrenia: Bridging preclinical evidence and clinical enthusiasm

British Journal of Pharmacology, Volume 183, Issue 19, Page 5701-5731, October 2026.
Abstract Antipsychotic drugs targeting dopamine receptors have been used to treat schizophrenia for decades, primarily alleviating positive symptoms such as hallucinations and delusions. However, they provide limited benefit for cognitive and negative symptoms—major contributors to poor outcomes—and are frequently associated with significant side ...
Brian J. Morris, Judith A. Pratt
wiley   +1 more source