Results 51 to 60 of about 15,918,440 (250)

The C‐terminal domain of yeast Arginyltransferase1 is essential for its catalytic activity

FEBS Open Bio, EarlyView.
Arginyltransferase 1 (Ate1), a eukaryotic enzyme, catalyses arginylation, transferring arginine from tRNA‐Arg to the amino terminus of the target protein. Overexpression of Ate1 in yeast is lethal and is dependent on arginylation. This study elucidates how mutations in the cofactor‐binding and active site of Ate1 and truncation of its structural ...
Vikas Kumar Yadav, Shweta Shweta, Manisha Malhotra, Vikash Maurya, Akhilesh Kumar   +4 more
wiley   +1 more source

Identification and characterization of a novel aac(6')-Iag associated with the blaIMP-1-integron in a multidrug-resistant Pseudomonas aeruginosa. [PDF]

PLoS ONE, 2013
In a continuing study from Dec 2006 to Apr 2008, we characterized nine multi-drug resistant Pseudomonas aeruginosa strains isolated from four patients in a ward at the Hiroshima University Hospital, Japan.
Kanao Kobayashi, Ikue Hayashi, Syuntaro Kouda, Fuminori Kato, Tamaki Fujiwara, Shizuo Kayama, Hideki Hirakawa, Hideyuki Itaha, Hiroki Ohge, Naomasa Gotoh, Tsuguru Usui, Akio Matsubara, Motoyuki Sugai   +12 more
doaj   +1 more source

Cytoplasmic N-Terminal Protein Acetylation Is Required for Efficient Photosynthesis in Arabidopsis [PDF]

, 2003
The Arabidopsis atmak3-1 mutant was identified on the basis of a decreased effective quantum yield of photosystem II. In atmak3-1, the synthesis of the plastome-encoded photosystem II core proteins D1 and CP47 is affected, resulting in a decrease in the ...
Masiero, S., Leister, D., Dietzmann, A., N. A. Gardner, Pesaresi, Paolo, Lutz Eichacker, Gardner, N., Dietzmann, Angela, Francesco Salamini, Salamini, Francesco, P. Pesaresi, Nora A. Gardner, Wickner, Reed B., Wickner, R., Salamini, F., Reed Wickner, Pesaresi, P., Leister, Dario, Gardner, Nora A., Masiero, Simona, Simona Masiero, Eichacker, L., Eichacker, Lutz A., D. Leister, Wickner, Reed, F. Salamini, Dario Leister, Paolo Pesaresi, R. Wickner, Gardner, N. A., L. Eichacker, Angela Dietzmann, A. Dietzmann, S. Masiero   +33 more
core   +1 more source

A Novel tRNA Half mt‐5’‐tiRNA‐Tyr Promotes Colorectal Cancer Proliferation via Inducing HARS2 Succinylation

Advanced Science, EarlyView.
A mitochondria‐derived tRNA half, mt‐5’‐tiRNA‐Tyr, is upregulated in colorectal cancer tissues and plasma and promotes tumor proliferation. It binds HARS2 and promotes CPT1A‐associated HARS2 K91 succinylation, disrupts HARS2–mt‐tRNA‐His association, impairs mitochondrial translation, enhances succinate‐linked metabolic reprogramming, and shows promise ...
Xinliang Gu, Danping Zhu, Xinwei Liu, Shangshang Hu, Xincheng Yang, Junjie Nie, Tao Xu, Yuqin Pan, Mu Xu, Huiling Sun, Shukui Wang   +10 more
wiley   +1 more source

The Cancer Cell Metabolic Reprogramming Remodels the Tumor Microenvironment: Molecular Mechanisms and Therapeutic Strategies

Advanced Science, EarlyView.
This review elucidates how cancer cell metabolic reprogramming—across glucose, lipid, amino acid, and nucleotide pathways—remodels the tumor microenvironment to suppress anti‐tumor immunity and promote immune escape. Targeting these metabolic axes offers promising strategies to overcome immunotherapy resistance and enhance cancer treatment.
Guoqing Xiang, Zhicheng Zhou, Xue Jiang, Zhenguang Du, Yangyang Zhan, Xinli Liu   +5 more
wiley   +1 more source

Transcriptomic Insights and Quantification of Free Amino Acids in Auricularia heimuer Cultivated on Corncob Substrate

Horticulturae
Substrate type exerts a critical influence on the growth, development, and nutritional quality of Auricularia heimuer. In this study, agricultural waste-derived corncob was used as the treatment group (T1), with sawdust serving as the control (CK), to ...
Xu Sun, Fangjie Yao, Fanchao Lai, Ming Fang, Lixin Lu, Xiaoxu Ma, Wei Wang, Jingjing Meng, Kaisheng Shao   +8 more
doaj   +1 more source

Insight on an arginine synthesis metabolon from the tetrameric structure of yeast acetylglutamate kinase. [PDF]

PLoS ONE, 2012
N-acetyl-L-glutamate kinase (NAGK) catalyzes the second, generally controlling, step of arginine biosynthesis. In yeasts, NAGK exists either alone or forming a metabolon with N-acetyl-L-glutamate synthase (NAGS), which catalyzes the first step and exists
Sergio de Cima, Fernando Gil-Ortiz, Marjolaine Crabeel, Ignacio Fita, Vicente Rubio   +4 more
doaj   +1 more source

Identification and Characterization of a Novel Chromosomal Aminoglycoside 2′-N-Acetyltransferase, AAC(2′)-If, From an Isolate of a Novel Providencia Species, Providencia wenzhouensis R33

Frontiers in Microbiology, 2021
Multidrug-resistant bacteria from different sources have been steadily emerging, and an increasing number of resistance mechanisms are being uncovered.
Kexin Zhou, Kexin Zhou, Kexin Zhou, Jialei Liang, Jialei Liang, Jialei Liang, Xu Dong, Xu Dong, Peiyao Zhang, Peiyao Zhang, Chunlin Feng, Chunlin Feng, Weina Shi, Weina Shi, Mengdi Gao, Mengdi Gao, Qiaoling Li, Qiaoling Li, Qiaoling Li, Xueya Zhang, Xueya Zhang, Xueya Zhang, Junwan Lu, Junwan Lu, Xi Lin, Xi Lin, Kewei Li, Kewei Li, Hailin Zhang, Hailin Zhang, Mei Zhu, Qiyu Bao, Qiyu Bao, Qiyu Bao   +33 more
doaj   +1 more source

Glucose and Glutamine Deprivation Promotes Breast Cancer Lung Metastasis via BRD4‐Dependent Enhancer Activation

Advanced Science, EarlyView.
To model a nutrient‐restricted tumor microenvironment, breast cancer cells were adapted to low glucose and glutamine levels. In the adapted cells, BRD4‐driven enhancer activation increases pro‐invasive EDN1 expression, facilitated by ATF3/c‐JUN and reinforced by enhancer RNA.
Poshan Yugal Bhattarai, Arathy Vasukutty, Yujin Na, Sung‐Chul Lim, Hong Seok Choi   +4 more
wiley   +1 more source

Structure and Biosynthesis of Mangotoxin Produced by the Plant Pathogen Pseudomonas syringae

Angewandte Chemie, EarlyView.
The structure of mangotoxin remained elusive for over two decades. Here, mangotoxin was isolated from the native producer, Pseudomonas syringae pv. syringae, and was determined to be an alkyne‐containing dipeptide. Mangotoxin inhibited the growth of multidrug‐resistant human pathogen Klebsiella pneumoniae.
Alexis H. Murray, Sohan Hazra, Ryan W. Mull, Erinn M. O'Neill, Bo Li   +4 more
wiley   +2 more sources