Results 41 to 50 of about 13,885 (249)

The Unexpected Advantages of Using D-Amino Acids for Peptide Self- Assembly into Nanostructured Hydrogels for Medicine [PDF]

, 2016
Self-assembled peptide hydrogels have brought innovation to the medicinal field, not only as responsive biomaterials but also as nanostructured therapeutic agents or as smart drug delivery systems.
Marchesan, Silvia, Melchionna, Michele, Styan, Katie E   +2 more
core   +1 more source

Merging Biocatalysis and Chemocatalysis in Flow: State‐of‐the‐Art and Future Directions for Sustainable Synthesis

Angewandte Chemie, EarlyView.
This review highlights recent advances in integrating biocatalysis and chemocatalysis in continuous flow to create streamlined, sustainable processes. It examines chemo‐enzymatic cascades combining at least one enzymatic and one chemical step, discusses challenges such as enzyme immobilization, leaching, and reactor clogging, and presents solutions ...
Petros Siasiaridis, Matteo Damian, Francesco G. Mutti   +2 more
wiley   +2 more sources

Properties of the thioredoxin fold superfamily are modulated by a single amino acid residue [PDF]

, 2009
The ubiquitous thioredoxin fold proteins catalyze oxidation, reduction, or disulfide exchange reactions depending on their redox properties. They also play vital roles in protein folding, redox control, and disease.
Guoping Ren, Daniel Stephan, Zhaohui Xu, Ying Zheng, Danming Tang, Rosemary S. Harrison, Mareike Kurz, Russell Jarrott, Stephen R. Shouldice, Annie Hiniker, Jennifer L. Martin, Begonña Heras, James C.A. Bardwell, Heras, Martin, Pan, Holmgren, Gruber, Krause, Lin, Zapun, Appenzeller-Herzog, Jonda, Quan, Mössner, Huber-Wunderlich, Woycechowsky, DeLano, Georgescu, Charbonnier, Kadokura, Su, Maeda, Inaba, Dai, Hiniker, Bessette, Collet, Nelson, Holmgren, Lundström, Hillson, Tapley, Hiniker, Brünger, Jones, Murshudov, Adams, Grimshaw, Grauschopf, McCarthy, Heras, Hibbert, Johannes, Ritz, Vallee, Rietsch, Chivers, Shaked, Heras, Salsbury, Malojcić, Street, Kallberg, Hahn, Guddat, Katti   +66 more
core   +3 more sources

Biophysical characterization of Cyclophilin B reveals membrane localization as its primary functional determinant as a prolyl isomerase. [PDF]

Protein Sci
Abstract The endoplasmic reticulum (ER) provides a specialized environment for the folding of secreted and membrane proteins, a process supported by many different chaperones. Among these chaperones, peptidyl‐prolyl cis/trans isomerases (PPIases) catalyze a rate‐limiting conformational step in protein folding, yet the principles governing isoform ...
DeVoe SC, Yost TC, Newton AJ, Grever GA, Ayala MF, Griffith WP, Latvala RD, Schmidpeter PAM.   +7 more
europepmc   +2 more sources

Studies on the subunit structure and amino acid sequence of triose phosphate isomerase from chicken breast muscle [PDF]

Biochemical Journal, 1974
1. Triose phosphate isomerase was prepared by chromatography on DEAE-cellulose of an (NH4)2SO4 fraction of an extract of homogenized chicken breast muscle. The product is homogeneous on gel electrophoresis and is suitable for growing crystals for X-ray work. The specific activity is 10000 units/mg and the value for E0.1%280 is 1.20. 2.
A J, Furth, J D, Milman, J D, Priddle, R E, Offord   +3 more
openaire   +2 more sources

Complete Determination of the Pin1 Catalytic Domain Thermodynamic Cycle by NMR Lineshape Analysis [PDF]

, 2011
The phosphorylation-specific peptidyl-prolyl isomerase Pin1 catalyzes the isomerization of the peptide bond preceding a proline residue between cis and trans isomers.
De, Soumya, Greenwood, Alexander I., Kovriguine, Evgueni, Lu, Kun Ping, Nicholson, Linda K., Rogals, Monique J.   +5 more
core   +2 more sources

Identification and characterization of the orf virus type I topoisomerase [PDF]

, 1995
Vaccinia virus (VV) and Shope fibroma virus (SFV), representatives of the orthopox and leporipox genera, respectively,encode type I DNA topoisomerases.
Nancy Klemperer, David J. Lyttle, Dominique Tauzin, Paula Traktman, Anthony J. Robinson, Bauer, Brill, Champoux, D'Arpa, DeLange, Fernandez-Beros, Fleming, Fleming, Fogelsong, Fraser, Goebel, Gupta, Higgins, Kim, Klemperer, Laemmu, Liu, Lynn, Mercer, Moore, Morham, Morham, Moss, Osheroff, Rigby, Rosel, Sanger, Schultz, Shaffer, Shuman, Shuman, Shuman, Shuman, Shuman, Shuman, Shuman, Shuman, Studier, Thrash, Traktman, Traktman, Traktman, Uemura, Upton, Vogelstein, Wang, Wang   +51 more
core   +5 more sources

A single amino acid substitution in the FAD-binding domain causes the inactivation of Propionibacterium Acnes isomerase [PDF]

Bioscience, Biotechnology, and Biochemistry, 2020
ABSTRACT We previously demonstrated the efficient production of trans 10, cis 12-conjugated linoleic acid (t10c12-CLA) in Lactococcus lactis by ectopically expressing a Propionibacterium acnes isomerase (pai) gene and also mentioned that a recombinant strain was unable to accumulate t10c12-CLA product, despite the normal transcription ...
Yu, Rao, Shi-Li, Li, Mei-Juan, Li, Sheng, Cui, Ke-Mian, Gou   +4 more
openaire   +2 more sources

Divergent roles of CprK paralogues from Desulfitobacterium hafniense in activating gene expression [PDF]

, 2008
Gene duplication and horizontal gene transfer play an important role in the evolution of prokaryotic genomes. We have investigated the role of three CprK paralogues from the cAMP receptor protein-fumarate and nitrate reduction regulator (CRP-FNR) family ...
Gabor, K., Oost, J., van der, Sene, K.H., Smidt, H., Vos, W.M., de   +4 more
core   +2 more sources

Native State Proline Isomerization:  An Intrinsic Molecular Switch [PDF]

, 2003
Exquisite control of biological function is achieved via tight regulation of the catalytic and binding activities of cellular proteins. The mechanistic details of protein regulation vary from targeted chemical modification of amino acid side chains (1 ...
Andreotti, Amy, Andreotti, Amy
core   +3 more sources