Results 21 to 30 of about 8,038 (247)

The NADPH oxidase NOX4 regulates redox and metabolic homeostasis preventing HCC progression

Hepatology, EarlyView., 2022
Loss of NOX4 in HCC tumor cells induces metabolic reprogramming in a Nrf2/MYC‐dependent manner to promote HCC progression. Abstract Background and Aims The NADPH oxidase NOX4 plays a tumor‐suppressor function in HCC. Silencing NOX4 confers higher proliferative and migratory capacity to HCC cells and increases their in vivo tumorigenic potential in ...
Irene Peñuelas‐Haro, Rut Espinosa‐Sotelo, Eva Crosas‐Molist, Macarena Herranz‐Itúrbide, Daniel Caballero‐Díaz, Ania Alay, Xavier Solé, Emilio Ramos, Teresa Serrano, María L. Martínez‐Chantar, Ulla G. Knaus, José M. Cuezva, Antonio Zorzano, Esther Bertran, Isabel Fabregat   +14 more
wiley   +1 more source

Conversion of an inactive xylose isomerase into a functional enzyme by co-expression of GroEL-GroES chaperonins in Saccharomyces cerevisiae

BMC Biotechnology, 2017
Background Second-generation ethanol production is a clean bioenergy source with potential to mitigate fossil fuel emissions. The engineering of Saccharomyces cerevisiae for xylose utilization is an essential step towards the production of this biofuel ...
Beatriz Temer, Leandro Vieira dos Santos, Victor Augusti Negri, Juliana Pimentel Galhardo, Pedro Henrique Mello Magalhães, Juliana José, Cidnei Marschalk, Thamy Lívia Ribeiro Corrêa, Marcelo Falsarella Carazzolle, Gonçalo Amarante Guimarães Pereira   +9 more
doaj   +1 more source

A single amino acid substitution in the FAD-binding domain causes the inactivation of Propionibacterium Acnes isomerase [PDF]

Bioscience, Biotechnology, and Biochemistry, 2020
ABSTRACT We previously demonstrated the efficient production of trans 10, cis 12-conjugated linoleic acid (t10c12-CLA) in Lactococcus lactis by ectopically expressing a Propionibacterium acnes isomerase (pai) gene and also mentioned that a recombinant strain was unable to accumulate t10c12-CLA product, despite the normal transcription ...
Yu, Rao, Shi-Li, Li, Mei-Juan, Li, Sheng, Cui, Ke-Mian, Gou   +4 more
openaire   +2 more sources

Pleiotropic Clostridioides difficile Cyclophilin PpiB Controls Cysteine-Tolerance, Toxin Production, the Central Metabolism and Multiple Stress Responses

Frontiers in Pharmacology, 2019
The Gram-positive pathogen Clostridioides difficile is the main bacterial agent of nosocomial antibiotic associated diarrhea. Bacterial peptidyl-prolyl-cis/trans-isomerases (PPIases) are well established modulators of virulence that influence the outcome
Can Murat Ünal, Can Murat Ünal, Mustafa Safa Karagöz, Mareike Berges, Mareike Berges, Christina Priebe, José Manuel Borrero de Acuña, Josef Wissing, Josef Wissing, Lothar Jänsch, Lothar Jänsch, Dieter Jahn, Dieter Jahn, Michael Steinert, Michael Steinert, Michael Steinert   +15 more
doaj   +1 more source

The Amino Acid Sequence of Δ5-3-Ketosteroid Isomerase of Pseudomonas testosteroni

Journal of Biological Chemistry, 1971
Abstract The primary structure of the identical subunits of crystalline Δ5-3-ketosteroid isomerase (EC 5.3.3.1) of Pseudomonas testosteroni has been determined by standard procedures to be the following: [see PDF for sequence] Thus, each subunit consists of a single polypeptide chain of 125 amino acid residues.
Ann M. Benson, Rebecca Jarabak, Paul Talalay   +2 more
openaire   +1 more source

Evaluating the Potential for Halogen Bonding in the Oxyanion Hole of Ketosteroid Isomerase Using Unnatural Amino Acid Mutagenesis [PDF]

ACS Chemical Biology, 2009
There has recently been an increasing interest in controlling macromolecular conformations and interactions through halogen bonding. Halogen bonds are favorable electrostatic interactions between polarized, electropositive chlorine, bromine, or iodine atoms and electronegative atoms such as oxygen or nitrogen.
Daniel A, Kraut, Michael J, Churchill, Phillip E, Dawson, Daniel, Herschlag   +3 more
openaire   +2 more sources

Highly Similar Sequence and Structure Yet Different Biophysical Behavior: A Computational Study of Two Triosephosphate Isomerases

, 2022
Homodimeric triosephosphate isomerases (TIMs) from Trypanosoma cruzi (TcTIM) and Trypanosoma brucei (TbTIM) have markedly similar amino-acid sequences and three-dimensional structures.
Cecilia Chávez-García (11973685), Mikko Karttunen, Cecilia Chávez-García, Mikko Karttunen (118139)   +3 more
core   +1 more source

Different transcription regulation routes are exerted by L- And D-amino acid enantiomers of peptide hormones [PDF]

, 2014
Conversion of one or more amino acids in eukaryotic peptides to the D-enantiomer configuration is catalyzed by specific L/D-peptide isomerases and it is a poorly investigated post-translational modification.
MOSCO, ALESSANDRO, GERDOL, MARCO, DE MORO, GIANLUCA, PALLAVICINI, Alberto, MANFRIN, CHIARA, Tom, Moshe, GIULIANINI, PIERO GIULIO   +6 more
core   +1 more source

Post-duplication charge evolution of phosphoglucose isomerases in teleost fishes through weak selection on many amino acid sites-1

, 2011
Copyright information:Taken from "Post-duplication charge evolution of phosphoglucose isomerases in teleost fishes through weak selection on many amino acid sites"http://www.biomedcentral.com/1471-2148/7/204BMC Evolutionary Biology 2007;7():204-204 ...
Mutsumi Nishida (38197), Yukuto Sato (68176)   +1 more
core   +1 more source

The Amino Acid Composition of Crystalline Δ5-3-Ketosteroid Isomerase and Its Tryptic Peptides

Journal of Biological Chemistry, 1966
Abstract The amino acid composition of crystalline Δ5-3-ketosteroid isomerase of Pseudomonas testosteroni is consistent with the formula Asp38, Thr21, Ser16, Glu38, Pro15, Gly29, Ala68, Val45, Met8, Ile12, Leu26, Tyr9, Phe25, Lys13, His9, Arg22. Eleven distinct peptides have been obtained after digestion of the heated enzyme by trypsin.
J, Boyer, P, Talalay
openaire   +2 more sources