Perampanel inhibition of AMPA receptor currents in cultured hippocampal neurons. [PDF]
PLoS ONE, 2014 Perampanel is an aryl substituted 2-pyridone AMPA receptor antagonist that was recently approved as a treatment for epilepsy. The drug potently inhibits AMPA receptor responses but the mode of block has not been characterized.
Chao-Yin Chen +3 more
doaj +7 more sources
AMPA receptors and their minions: auxiliary proteins in AMPA receptor trafficking [PDF]
Cellular and Molecular Life Sciences, 2019 To correctly transfer information, neuronal networks need to continuously adjust their synaptic strength to extrinsic stimuli. This ability, termed synaptic plasticity, is at the heart of their function and is, thus, tightly regulated.
Diane Bissen, F. Foss, A. Acker-Palmer
semanticscholar +4 more sources
Single-Particle Tracking of AMPA Receptor-Containing Vesicles [PDF]
Bio-ProtocolAMPA-type receptors are transported large distances to support synaptic plasticity at distal dendritic locations. Studying the motion of AMPA receptor+ vesicles can improve our understanding of the mechanisms that underlie learning and memory ...
Victor Wong +3 more
doaj +2 more sources
Control of AMPA receptor activity by the extracellular loops of auxiliary proteins [PDF]
eLife, 2017 At synapses throughout the mammalian brain, AMPA receptors form complexes with auxiliary proteins, including TARPs. However, how TARPs modulate AMPA receptor gating remains poorly understood. We built structural models of TARP-AMPA receptor complexes for
Irene Riva +4 more
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AMPA Receptors: A Key Piece in the Puzzle of Memory Retrieval [PDF]
Frontiers in Human Neuroscience, 2021 Retrieval constitutes a highly regulated and dynamic phase in memory processing. Its rapid temporal scales require a coordinated molecular chain of events at the synaptic level that support transient memory trace reactivation.
Magdalena Pereyra +3 more
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Stargazin Modulation of AMPA Receptors [PDF]
Cell Reports, 2016 Fast excitatory synaptic signaling in the mammalian brain is mediated by AMPA-type ionotropic glutamate receptors. In neurons, AMPA receptors co-assemble with auxiliary proteins, such as stargazin, which can markedly alter receptor trafficking and gating.
Sana A. Shaikh +7 more
doaj +4 more sources
SARM1 is essential for NMDA receptor-dependent endocytosis of AMPA receptors in hippocampal neurons
Neuroscience ResearchLong-term depression (LTD) is a form of synaptic plasticity thought to be the cellular basis of experience-dependent learning and memory. LTD is caused by an activity-dependent decrease in cell surface α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid
Misaki Morishita, Shinji Matsuda
doaj +2 more sources
Exploring the impact of the stargazin V143L mutation on the dynamics of the AMPA receptor: stargazin complex. [PDF]
Front Cell NeurosciGouveia RP +4 more
europepmc +3 more sources
SynDIG1 promotes excitatory synaptogenesis independent of AMPA receptor trafficking and biophysical regulation. [PDF]
PLoS ONE, 2013 AMPA receptors-mediators of fast, excitatory transmission and synaptic plasticity in the brain-achieve great functional diversity through interaction with different auxiliary subunits, which alter both the trafficking and biophysical properties of these ...
Kathryn L Lovero +3 more
doaj +1 more source
Auxiliary Subunits Regulate the Dendritic Turnover of AMPA Receptors in Mouse Hippocampal Neurons
Frontiers in Molecular Neuroscience, 2021 Different families of auxiliary subunits regulate the function and trafficking of native α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors in the central nervous system. While a facilitatory role of auxiliary subunits in ER export and
Ali Harb +7 more
doaj +1 more source