Results 1 to 10 of about 2,334,241 (398)

Perampanel inhibition of AMPA receptor currents in cultured hippocampal neurons. [PDF]

open access: yesPLoS ONE, 2014
Perampanel is an aryl substituted 2-pyridone AMPA receptor antagonist that was recently approved as a treatment for epilepsy. The drug potently inhibits AMPA receptor responses but the mode of block has not been characterized.
Chao-Yin Chen   +3 more
doaj   +13 more sources

Regulation of AMPA receptors in spinal nociception [PDF]

open access: yesMolecular Pain, 2010
The functional properties of α-amino-3-hydroxy-5-methy-4-isoxazole propionate (AMPA) receptors in different brain regions, such as hippocampus and cerebellum, have been well studied in vitro and in vivo. The AMPA receptors present a unique characteristic
Lin Qing   +5 more
doaj   +7 more sources

AMPA receptors and their minions: auxiliary proteins in AMPA receptor trafficking [PDF]

open access: yesCellular and Molecular Life Sciences, 2019
To correctly transfer information, neuronal networks need to continuously adjust their synaptic strength to extrinsic stimuli. This ability, termed synaptic plasticity, is at the heart of their function and is, thus, tightly regulated.
Diane Bissen, F. Foss, A. Acker-Palmer
semanticscholar   +5 more sources

AMPA receptor subunit expression in the endoplasmic reticulum in frontal cortex of elderly patients with schizophrenia. [PDF]

open access: yesPLoS ONE, 2012
Several lines of evidence indicate altered trafficking of α-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate (AMPA) receptors in schizophrenia. Previous reports have shown potential changes in the trafficking of AMPA receptors based on subunit expression
John C Hammond   +3 more
doaj   +5 more sources

Stargazin Modulation of AMPA Receptors [PDF]

open access: yesCell Reports, 2016
Fast excitatory synaptic signaling in the mammalian brain is mediated by AMPA-type ionotropic glutamate receptors. In neurons, AMPA receptors co-assemble with auxiliary proteins, such as stargazin, which can markedly alter receptor trafficking and gating.
Sana A. Shaikh   +7 more
doaj   +5 more sources

Glycine Potentiates AMPA Receptor Function through Metabotropic Activation of GluN2A-containing NMDA Receptors [PDF]

open access: yesFrontiers in Molecular Neuroscience, 2016
NMDA receptors are Ca2+-permeable ion channels. The activation of NMDA receptors requires agonist glutamate and co-agonist glycine. Recent evidence indicates that NMDA receptor also has metabotropic function.
Li-Jun Li   +15 more
doaj   +4 more sources

Ligand-dependent opening of the multiple AMPA receptor conductance states: a concerted model [PDF]

open access: yes, 2014
Modulation of the properties of AMPA receptors at the post-synaptic membrane is one of the main suggested mechanisms behind synaptic plasticity in the central nervous system of vertebrates. Electrophysiological recordings of single channels stimulated with agonists showed that both recombinant and native AMPA receptors visit multiple conductance states
Edelstein, Stuart J   +3 more
arxiv   +6 more sources

SynDIG1 promotes excitatory synaptogenesis independent of AMPA receptor trafficking and biophysical regulation. [PDF]

open access: yesPLoS ONE, 2013
AMPA receptors-mediators of fast, excitatory transmission and synaptic plasticity in the brain-achieve great functional diversity through interaction with different auxiliary subunits, which alter both the trafficking and biophysical properties of these ...
Kathryn L Lovero   +3 more
doaj   +2 more sources

Membrane lipid rafts are required for AMPA receptor tyrosine phosphorylation [PDF]

open access: yesFrontiers in Synaptic Neuroscience, 2022
Membrane lipid rafts are sphingolipids and cholesterol-enriched membrane microdomains, which form a center for the interaction or assembly of palmitoylated signaling molecules, including Src family non-receptor type protein tyrosine kinases.
Takashi Hayashi, Takashi Hayashi
doaj   +2 more sources

Residence times of receptors in dendritic spines analyzed by simulations in empirical domains [PDF]

open access: yes, 2014
Analysis of high-density superresolution imaging of receptors reveal the organization of dendrites at the nano-scale resolution. We present here simulations in empirical live cell images, which allows converting local information extracted from short range trajectories into simulations of long range trajectories.
Holcman, D., Hoze, N.
arxiv   +5 more sources

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