Results 1 to 10 of about 2,373,510 (375)

Perampanel inhibition of AMPA receptor currents in cultured hippocampal neurons. [PDF]

open access: yesPLoS ONE, 2014
Perampanel is an aryl substituted 2-pyridone AMPA receptor antagonist that was recently approved as a treatment for epilepsy. The drug potently inhibits AMPA receptor responses but the mode of block has not been characterized.
Chao-Yin Chen   +3 more
doaj   +7 more sources

Single-Particle Tracking of AMPA Receptor-Containing Vesicles [PDF]

open access: yesBio-Protocol
AMPA-type receptors are transported large distances to support synaptic plasticity at distal dendritic locations. Studying the motion of AMPA receptor+ vesicles can improve our understanding of the mechanisms that underlie learning and memory ...
Victor Wong   +3 more
doaj   +2 more sources

SynDIG1 promotes excitatory synaptogenesis independent of AMPA receptor trafficking and biophysical regulation. [PDF]

open access: yesPLoS ONE, 2013
AMPA receptors-mediators of fast, excitatory transmission and synaptic plasticity in the brain-achieve great functional diversity through interaction with different auxiliary subunits, which alter both the trafficking and biophysical properties of these ...
Kathryn L Lovero   +3 more
doaj   +2 more sources

α-Lipoic Acid Derivatives as Allosteric Modulators for Targeting AMPA-Type Glutamate Receptors’ Gating Modules

open access: yesCells, 2022
The ionotropic glutamate receptor subtype α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) is responsible for most excitatory transmission in the brain.
Mohammad Qneibi   +3 more
doaj   +1 more source

Auxiliary Subunits Regulate the Dendritic Turnover of AMPA Receptors in Mouse Hippocampal Neurons

open access: yesFrontiers in Molecular Neuroscience, 2021
Different families of auxiliary subunits regulate the function and trafficking of native α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors in the central nervous system. While a facilitatory role of auxiliary subunits in ER export and
Ali Harb   +7 more
doaj   +1 more source

AMPA receptor structure and auxiliary subunits

open access: yesJournal of Physiology, 2020
Fast excitatory synaptic transmission in the mammalian brain is largely mediated by AMPA‐type ionotropic glutamate receptors (AMPARs), which are activated by the neurotransmitter glutamate.
Aichurok Kamalova, T. Nakagawa
semanticscholar   +1 more source

The early stage formation of PI3K-AMPAR GluR2 subunit complex facilitates the long term neuroprotection induced by propofol post-conditioning in rats. [PDF]

open access: yesPLoS ONE, 2013
Previously, we have shown that the phosphoinositide-3-kinase (PI3K) mediated acute (24 h) post-conditioning neuroprotection induced by propofol.
Haiyun Wang   +6 more
doaj   +1 more source

Modulating Excitatory Synaptic Neurotransmission: Potential Treatment for Neurological Disease?

open access: yesNeurobiology of Disease, 1998
Excitatory neurotransmission at many CNS synapses depends upon AMPA-type glutamate receptors. Derangements in AMPA receptor-mediated synaptic transmission may be a contributing factor in neurological and neurodegenerative diseases and could be a target ...
Kelvin A. Yamada
doaj   +1 more source

Copine-6 is a Ca2+ sensor for activity-induced AMPA receptor exocytosis

open access: yesCell Reports, 2023
Summary: The recruitment of synaptic α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors underlies the strengthening of neuronal connectivity during learning and memory. This process is triggered by N-methyl-D-aspartate (NMDA) receptor-
Jing Zhi Anson Tan   +10 more
doaj   +1 more source

Hippocampal Memory Recovery After Acute Stress: A Behavioral, Morphological and Molecular Study [PDF]

open access: yes, 2018
Indexación: Scopus.Laboratory of Neuroplasticity and Neurogenetics, Department of Biochemistry and Molecular Biology, Faculty of Chemistry and Pharmaceutical Sciences, Universidad de Chile, Santiago, Chile, 2Laboratorio Farmacología del Comportamiento ...
Ana M. Avalos   +13 more
core   +5 more sources

Home - About - Disclaimer - Privacy