Results 1 to 10 of about 2,689,488 (154)
Perampanel inhibition of AMPA receptor currents in cultured hippocampal neurons. [PDF]
PLoS ONE, 2014 Perampanel is an aryl substituted 2-pyridone AMPA receptor antagonist that was recently approved as a treatment for epilepsy. The drug potently inhibits AMPA receptor responses but the mode of block has not been characterized.
Chao-Yin Chen +3 more
doaj +19 more sources
Neuron, 2019 AMPA- and NMDA-type glutamate receptors mediate distinct postsynaptic signals that differ characteristically among synapses. How postsynaptic AMPA- and NMDA-receptor levels are regulated, however, remains unclear.
Jinye Dai +2 more
exaly +2 more sources
Neuron, 2018 AMPA receptors are essential for fast excitatory transmission in the CNS. Autoantibodies to AMPA receptors have been identified in humans with autoimmune encephalitis and severe defects of hippocampal function.
Francesco Mannará +2 more
exaly +2 more sources
Optogenetic Control of Synaptic AMPA Receptor Endocytosis Reveals Roles of LTD in Motor Learning
Neuron, 2018 Long-term depression (LTD) of AMPA-type glutamate receptor (AMPA receptor)-mediated synaptic transmission has been proposed as a cellular substrate for learning and memory.
Wataru Kakegawa +2 more
exaly +2 more sources
Activation and Desensitization Mechanism of AMPA Receptor-TARP Complex by Cryo-EM
Cell, 2017 Shanshuang Chen +2 more
exaly +2 more sources
Hippocampal AMPA receptor assemblies and mechanism of allosteric inhibition
Nature, 2021 AMPA-selective glutamate receptors mediate the transduction of signals between the neuronal circuits of the hippocampus1. The trafficking, localization, kinetics and pharmacology of AMPA receptors are tuned by an ensemble of auxiliary protein subunits ...
Jie Yu +5 more
semanticscholar +1 more source
SynDIG1 promotes excitatory synaptogenesis independent of AMPA receptor trafficking and biophysical regulation. [PDF]
PLoS ONE, 2013 AMPA receptors-mediators of fast, excitatory transmission and synaptic plasticity in the brain-achieve great functional diversity through interaction with different auxiliary subunits, which alter both the trafficking and biophysical properties of these ...
Kathryn L Lovero +3 more
doaj +1 more source
Auxiliary Subunits Regulate the Dendritic Turnover of AMPA Receptors in Mouse Hippocampal Neurons
Frontiers in Molecular Neuroscience, 2021 Different families of auxiliary subunits regulate the function and trafficking of native α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors in the central nervous system. While a facilitatory role of auxiliary subunits in ER export and
Ali Harb +7 more
doaj +1 more source
Cells, 2022 The ionotropic glutamate receptor subtype α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) is responsible for most excitatory transmission in the brain.
Mohammad Qneibi +3 more
doaj +1 more source
AMPA receptor structure and auxiliary subunits
Journal of Physiology, 2020 Fast excitatory synaptic transmission in the mammalian brain is largely mediated by AMPA‐type ionotropic glutamate receptors (AMPARs), which are activated by the neurotransmitter glutamate.
Aichurok Kamalova, Terunaga Nakagawa
semanticscholar +1 more source