LTD expression is independent of glutamate receptor subtype
Long-term depression (LTD) is a form of synaptic plasticity that plays a major role in the activity-dependent reshaping of synaptic transmission.
Adam J Granger, Roger A Nicoll
doaj +1 more source
Detection in Molecular Communications with Ligand Receptors under Molecular Interference [PDF]
Molecular Communications (MC) is a bio-inspired communication technique that uses molecules to transfer information among bio-nano devices. In this paper, we focus on the detection problem for biological MC receivers employing ligand receptors to infer the transmitted messages encoded into the concentration of molecules, i.e., ligands.
arxiv
Comprehensive analysis of cortical astrocyte gene expression across the lifespan. Profiling dynamic changes of key astrocyte genes reveals functional shifts. Astrocytes contribute to gene‐length‐dependent transcription decline in the aging brain. ABSTRACT Astrocytes are the most abundant glial cell type in the central nervous system (CNS).
Xiaoran Wei+2 more
wiley +1 more source
Instantons in the working memory: implications for schizophrenia [PDF]
The influence of the synaptic channel properties on the stability of delayed activity maintained by recurrent neural network is studied. The duration of excitatory post-synaptic current (EPSC) is shown to be essential for the global stability of the delayed response.
arxiv
Currents mediated by non-NMDA glutamate receptors in rat magnocellular basal forebrain neurones in primary culture [PDF]
Patch-clamp techniques were used to record glutamate receptor-mediated responses from magnocellular rat basal forebrain neurones maintained in dissociated culture.
Waters, David Jack
core
Synaptic transmission and plasticity in the spinal cord substantia gelatinosa: the role of GluR2, GluR5 and GluR6 glutamate receptor subunits [PDF]
To understand the physiological role of the AMPA-type or kainate-type ionotropic glutamate receptors and their participation in sensory information processing, including pain, it will be necessary to develop a comprehensive description of their actions ...
Youn, Dong-ho
core +3 more sources
Differential Regulation of AMPA Receptor and GABA Receptor Trafficking by Tumor Necrosis Factor-α
The proinflammatory cytokine tumor necrosis factor-α (TNFα) causes a rapid exocytosis of AMPA receptors in hippocampal pyramidal cells and is constitutively required for the maintenance of normal surface expression of AMPA receptors.
D. Stellwagen+3 more
semanticscholar +1 more source
Intracellular machinery for the transport of AMPA receptors [PDF]
AMPA‐type glutamate receptors are one of the most dynamic components of excitatory synapses. Their regulated addition and removal from synapses leads to long‐lasting forms of synaptic plasticity, known as long‐term potentiation (LTP) and long‐term depression (LTD).
openaire +5 more sources
Psychostimulant-induced neuroadaptations in nucleus accumbens AMPA receptor transmission.
Medium spiny neurons of the nucleus accumbens serve as the interface between corticolimbic regions that elicit and modulate motivated behaviors, including those related to drugs of abuse, and motor regions responsible for their execution.
R. Pierce, M. Wolf
semanticscholar +1 more source
Downregulation of the expression of silent information regulator sirtuin 1 (SIRT1) exacerbates neuronal degeneration and loss by activating forkhead box O1 (FOXO1) acetylation and promoting endoplasmic reticulum stress (ERSA)‐mediated apoptosis in aging.
Nan Zhang+20 more
wiley +1 more source