Results 151 to 160 of about 100,721 (313)
Glia, Volume 74, Issue 4, April 2026.Ronzano et al. show that neuronal activity promotes node‐like cluster (NLC) formation before (re)myelination by regulating β1Nav and Nav1.1, which are essential for NLC assembly. This may represent an intermediate step in activity‐driven myelination and contribute to the regulation of axonal conduction.
Rémi Ronzano +10 more
wiley +1 more source
α-Amino- 3-hydroxy-5-methyl-4-isoxazolepropionic acid glutamate receptor (GRIA; AMPAR); glutamate receptor, ionotropic, AMPA 2 (GRIA2; GLUR2) [PDF]
, 2008 openalex +1 more source
Toxic mechanisms of amyloid oligomers and therapeutic strategies
Protein Science, Volume 35, Issue 4, April 2026.Abstract Amyloid oligomers are increasingly recognized as the major toxic contributors across protein‐misfolding disorders. In this review, we cover mechanistic evidence showing how these transient and structurally heterogeneous oligomers disrupt cellular homeostasis by: (i) permeabilizing lipid membranes and forming ion‐conducting pores; (ii ...
Magdalena I. Ivanova +2 more
wiley +1 more source
Evaluation of preclinical antipsychotic models used to support first‐in‐human clinical trials
British Journal of Pharmacology, Volume 183, Issue 7, Page 1364-1389, April 2026.Abstract Schizophrenia is regarded as a complex and heterogeneous psychiatric disorder, characterised by diverse symptoms and comorbidities, which complicate both clinical management and drug development. Current pharmacological treatment, primarily based on dopamine D2 receptor antagonism or partial agonism, which has not markedly progressed since the
Thi Viet Ha Nguyen +2 more
wiley +1 more source
Brain SciencesBackground/Objectives: Palatability significantly influences food consumption, often leading to overeating and obesity by activating the brain’s reward systems.
Refugio Cruz-Trujillo +7 more
doaj +1 more source
British Journal of Pharmacology, Volume 183, Issue 7, Page 1313-1340, April 2026.Abstract Chronic pain, marked by nociceptive sensitization and maladaptive neuroplasticity, affects 30% of the global population with escalating socioeconomic burdens. Epidemiological data show a 2‐3‐fold increase in neuropsychiatric co‐morbidities among individuals with chronic pain, where epigenetic dysregulation serves as a key mechanism linking ...
Kai Zhang +18 more
wiley +1 more source
Insights Into the Antigenic Repertoire of Unclassified Synaptic Antibodies
Annals of Clinical and Translational Neurology, Volume 13, Issue 3, Page 547-561, March 2026.ABSTRACT Objective We sought to characterize the sixth most common finding in our neuroimmunological laboratory practice (tissue assay‐observed unclassified neural antibodies [UNAs]), combining protein microarray and phage immunoprecipitation sequencing (PhIP‐Seq). Methods Patient specimens (258; 133 serums; 125 CSF) meeting UNA criteria were profiled;
Michael Gilligan +22 more
wiley +1 more source
Opposing Gradients of Ribbon Size and AMPA Receptor Expression Underlie Sensitivity Differences among Cochlear-Nerve/Hair-Cell Synapses [PDF]
, 2011 Leslie D. Liberman +2 more
openalex +1 more source
Dynamics of AMPA receptors regulate epileptogenesis in patients with epilepsy [PDF]
, 2023 Tsuyoshi Eiro +30 more
openalex +1 more source