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Accelerated Amyloid Beta Pathogenesis by Bacterial Amyloid FapC [PDF]
Advanced Science, 2020 The gut–brain axis has attracted increasing attention in recent years, fueled by accumulating symptomatic, physiological, and pathological findings. In this study, the aggregation and toxicity of amyloid beta (Aβ), the pathogenic peptide associated with ...
Ibrahim Javed +10 more
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Amyloid-beta peptide and tau protein crosstalk in Alzheimer’s disease
Neural Regeneration Research, 2022 Alzheimer’s disease is a neurodegenerative disease that accounts for most of the 50-million dementia cases worldwide in 2018. A large amount of evidence supports the amyloid cascade hypothesis, which states that amyloid-beta accumulation triggers tau ...
Alejandro R Roda +4 more
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Plasma pyroglutamate‐modified amyloid beta differentiates amyloid pathology
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2020 Introduction Pyroglutamate‐modified amyloid β (AβpE3) could be a biomarker for Aβ plaque pathology in the brain. An ultra‐high‐sensitive assay is needed for detecting AβpE3‐40.
Pei‐Ning Wang +6 more
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The amyloid-beta wave hypothesis of Alzheimer’s disease [PDF]
Frontiers in Cellular and Infection MicrobiologyAlzheimer’s disease (AD) is a complex and multifactorial disorder that affects all races and genders. Genetic traits influenced by lifestyle and environment lead to a tremendous amount of heterogeneity in Alzheimer’s disease onset and severity ...
Sean J. Miller +6 more
doaj +2 more sources
Destruxin E Decreases Beta-Amyloid Generation by Reducing Colocalization of Beta-Amyloid-Cleaving Enzyme 1 and Beta-Amyloid Protein Precursor [PDF]
Neurodegenerative Diseases, 2009 Alzheimer-disease-associated beta-amyloid (A beta) is produced by sequential endoproteolysis of beta-amyloid protein precursor (beta APP): the extracellular portion is shed by cleavage in the juxtamembrane region by beta-amyloid-cleaving enzyme (BACE ...
Dohi, Keiji +27 more
core +4 more sources
Human microglial cells synthesize albumin in brain [PDF]
, 2008 Albumin has been implicated in Alzheimer's disease since it can bind to and transport amyloid beta, the causative agent; albumin is also a potent inhibitor of amyloid beta polymerization.
Bonghee Lee +9 more
core +10 more sources
Frontiers in Aging Neuroscience, 2020 Familial Alzheimer’s Disease (FAD) caused by Presenilin-1 (PS1) mutations is characterized by early onset, cognitive impairment, and dementia. Impaired gamma secretase function favors production of longer beta-amyloid species in PS1 FAD.
Felix Dinkel +7 more
doaj +1 more source
Journal of Neuroinflammation, 2021 Background Brain inflammation has been increasingly associated with early amyloid accumulation in Alzheimer’s disease models; however, evidence of its occurrence in humans remains scarce.
Lisi Flores-Aguilar +6 more
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Lowering beta-amyloid levels rescues learning and memory in a Down syndrome mouse model. [PDF]
PLoS ONE, 2010 beta-amyloid levels are elevated in Down syndrome (DS) patients throughout life and are believed to cause Alzheimer's disease (AD) in adult members of this population.
William J Netzer +7 more
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Beta amyloid deposition and cognitive decline in Parkinson’s disease: a study of the PPMI cohort
Molecular Brain, 2022 The accumulation of beta amyloid in the brain has a complex and poorly understood impact on the progression of Parkinson’s disease pathology and much controversy remains regarding its role, specifically in cognitive decline symptoms.
Alexander S. Mihaescu +6 more
doaj +1 more source