Cognitive and brain cytokine profile of non-demented individuals with cerebral amyloid-beta deposition [PDF]
Journal of Neuroinflammation, 2021 Background Brain inflammation has been increasingly associated with early amyloid accumulation in Alzheimer’s disease models; however, evidence of its occurrence in humans remains scarce.
Lisi Flores-Aguilar +6 more
doaj +2 more sources
Thermodynamics of beta-amyloid fibril formation [PDF]
, 2004 Amyloid fibers are aggregates of proteins. They are built out of a peptide called $\beta$--amyloid (A$\beta$) containing between 41 and 43 residues, produced by the action of an enzyme which cleaves a much larger protein known as the Amyloid Precursor Protein (APP).
F. Simona +4 more
arxiv +3 more sources
Oligomerization of amyloid Abeta peptides using hydrogen bonds and hydrophobicity forces [PDF]
Biophys. J. 87 (2004) 3657-3664, 2004 The 16-22 amino acid fragment of the beta-amyloid peptide associated with the Alzheimer's disease, Abeta, is capable of forming amyloid fibrils. Here we study the aggregation mechanism of Abeta(16-22) peptides by unbiased thermodynamic simulations at the atomic level for systems of one, three and six Abeta(16-22) peptides.
Anders Irbäck +48 more
arxiv +5 more sources
Estrogen protects neuronal cells from amyloid beta-induced apoptosis via regulation of mitochondrial proteins and function [PDF]
BMC Neuroscience, 2006 Background Neurodegeneration in Alzheimer's disease is associated with increased apoptosis and parallels increased levels of amyloid beta, which can induce neuronal apoptosis.
Iwamoto Sean +4 more
doaj +4 more sources
BETASCAN: probable beta-amyloids identified by pairwise probabilistic analysis. [PDF]
PLoS Computational Biology, 2009 Amyloids and prion proteins are clinically and biologically important beta-structures, whose supersecondary structures are difficult to determine by standard experimental or computational means.
Allen W Bryan +4 more
doaj +4 more sources
Amyloid-beta peptide and tau protein crosstalk in Alzheimer’s disease
Neural Regeneration Research, 2022 Alzheimer’s disease is a neurodegenerative disease that accounts for most of the 50-million dementia cases worldwide in 2018. A large amount of evidence supports the amyloid cascade hypothesis, which states that amyloid-beta accumulation triggers tau ...
Alejandro R Roda +4 more
doaj +1 more source
Human microglial cells synthesize albumin in brain [PDF]
, 2008 Albumin has been implicated in Alzheimer's disease since it can bind to and transport amyloid beta, the causative agent; albumin is also a potent inhibitor of amyloid beta polymerization.
Bonghee Lee +9 more
core +8 more sources
Frontiers in Aging Neuroscience, 2020 Familial Alzheimer’s Disease (FAD) caused by Presenilin-1 (PS1) mutations is characterized by early onset, cognitive impairment, and dementia. Impaired gamma secretase function favors production of longer beta-amyloid species in PS1 FAD.
Felix Dinkel +7 more
doaj +1 more source
Beta amyloid deposition and cognitive decline in Parkinson’s disease: a study of the PPMI cohort
Molecular Brain, 2022 The accumulation of beta amyloid in the brain has a complex and poorly understood impact on the progression of Parkinson’s disease pathology and much controversy remains regarding its role, specifically in cognitive decline symptoms.
Alexander S. Mihaescu +6 more
doaj +1 more source
Lowering beta-amyloid levels rescues learning and memory in a Down syndrome mouse model. [PDF]
PLoS ONE, 2010 beta-amyloid levels are elevated in Down syndrome (DS) patients throughout life and are believed to cause Alzheimer's disease (AD) in adult members of this population.
William J Netzer +7 more
doaj +1 more source