Results 41 to 50 of about 45,801 (303)

cAMP-Inhibits Cytoplasmic Phospholipase A(2) and Protects Neurons against Amyloid-beta-Induced Synapse Damage [PDF]

, 2015
A key event in Alzheimer’s disease (AD) is the production of amyloid-β (Aβ) peptides and the loss of synapses. In cultured neurons Aβ triggered synapse damage as measured by the loss of synaptic proteins. α-synuclein (αSN), aggregates of which accumulate
Bate, C, Williams, A
core   +2 more sources

Potential neuroprotective of trans-resveratrol a promising agent tempeh and soybean seed coats-derived against beta-amyloid neurotoxicity on primary culture of nerve cells induced by 2-methoxyethanol

Brazilian Journal of Biology, 2021
Resveratrol, a natural polyphenol found in tempeh, has not been investigated especially in vitro as a neuroprotective agent against 2-methoxyethanol (2-ME)-induced beta-amyloid cytotoxicity. Beta amyloid peptides (Aβ) could initiate neurotoxic events and
Y. Irnidayanti, D. R. Sutiono, N. Ibrahim, P. H. Wisnuwardhani, A. Santoso   +4 more
doaj   +1 more source

Electrochemical, Photoelectrochemical and Electrochemiluminescent Biosensors for the Detection of Betaamyloid Peptides and Their Aggregates

International Journal of Electrochemical Science, 2019
Beta-amyloid (Aβ) peptides are the specific biomarkers of Alzheimer's disease (AD). Many clinical studies have suggested that abnormal levels of Aβ peptides in blood, cerebrospinal fluid and brain tissue are closely related to the progression of AD ...
Ming La, Changdong Chen, Xichao Xia, Jihong Zhang, Binbin Zhou   +4 more
doaj   +1 more source

Brain Region-Specific Differences in Amyloid-β Plaque Composition in 5XFAD Mice

Life, 2023
Senile plaques consisting of amyloid-beta (Aβ) peptides are a major pathological hallmark of Alzheimer’s disease (AD). Aβ peptides are heterogeneous regarding the exact length of their amino- and carboxy-termini. Aβ1-40 and Aβ1-42 are often considered to
Angelika Sabine Bader, Marius-Uwe Gnädig, Merle Fricke, Luca Büschgens, Lena Josefine Berger, Hans-Wolfgang Klafki, Thomas Meyer, Olaf Jahn, Sascha Weggen, Oliver Wirths   +9 more
doaj   +1 more source

Selective inhibition of phosphodiesterases 4, 5 and 9 induces HSP20 phosphorylation and attenuates amyloid beta 1-42 mediated cytotoxicity [PDF]

, 2016
Phosphodiesterase (PDE) inhibitors are currently under evaluation as agents that may facilitate the improvement of cognitive impairment associated with Alzheimer's disease. Our aim was to determine whether inhibitors of PDEs 4,5 and 9 could alleviate the
Baillie, George S., Cameron, Ryan T., Day, Jon P., Parachikova, Anna I., Whiteley, Ellanor   +4 more
core   +1 more source

Oligomers mediate the spatial transmission of Aβ peptide aggregation

Communications Chemistry
Alzheimer’s disease (AD) is marked by the abnormal aggregation of amyloid-beta peptides within the central nervous system. The formation of amyloid fibrils from amyloid-beta peptides is a hallmark of AD Here, we demonstrate that the aggregation of ...
Quentin Peter, Chris Taylor, Urszula Lapinska, Jiapeng Wei, Thomas C. T. Michaels, Paolo Arosio, Sara Linse, Tuomas P. J. Knowles   +7 more
doaj   +1 more source

Mulberry Fruit Cultivar ‘Chiang Mai’ Prevents Beta-Amyloid Toxicity in PC12 Neuronal Cells and in a Drosophila Model of Alzheimer’s Disease

Molecules, 2020
Alzheimer’s disease (AD) is the most common form of dementia, characterized by chronic neuron loss and cognitive problems. Aggregated amyloid beta (Aβ) peptides, a product of cleaved amyloid precursor protein (APP) by beta-secretase 1 (BACE-1), have been
Uthaiwan Suttisansanee, Somsri Charoenkiatkul, Butsara Jongruaysup, Somying Tabtimsri, Dalad Siriwan, Piya Temviriyanukul   +5 more
doaj   +1 more source

Neurodevelopmental disorders and microcephaly: how apoptosis, the cell cycle, tau and amyloid-β precursor protein APPly

Frontiers in Molecular Neuroscience, 2023
Recent studies promote new interest in the intersectionality between autism spectrum disorder (ASD) and Alzheimer’s Disease. We have reported high levels of Amyloid-β Precursor Protein (APP) and secreted APP-alpha (sAPPa) and low levels of amyloid-beta ...
Deborah K. Sokol, Debomoy K. Lahiri, Debomoy K. Lahiri   +2 more
doaj   +1 more source

Natural Compounds as Beneficial Antioxidant Agents in Neurodegenerative Disorders: A Focus on Alzheimer’s Disease [PDF]

, 2019
The positive role of nutrition in chronic neurodegenerative diseases (NDs) suggests that dietary interventions represent helpful tools for preventing NDs.
Antonella Amato, Flavia Mulè, Simona Terzo   +2 more
core   +1 more source

Investigation of low amyloid level toxicity effects on the function of hippocampal neurons

Open Life Sciences, 2015
Alzheimer disease (AD) is responsible for the majority of elderly dementia cases. There are multiple mouse models of AD, however, none of them completely recapitulate human pathology.
Popugaeva Elena, Pchitskaya Ekaterina, Zhang Hua, Vlasova Olga, Bezprozvanny Ilya   +4 more
doaj   +1 more source