Probing oligomerization of amyloid beta peptide in silico
Molecular BioSystems, 2017 Simulations reveal molecular-level details of aggregation of amyloid β peptide that is implicated in fatal Alzheimer's disease.
L. Dorosh, M. Stepanova
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Brain Region-Specific Differences in Amyloid-β Plaque Composition in 5XFAD Mice
Life, 2023 Senile plaques consisting of amyloid-beta (Aβ) peptides are a major pathological hallmark of Alzheimer’s disease (AD). Aβ peptides are heterogeneous regarding the exact length of their amino- and carboxy-termini. Aβ1-40 and Aβ1-42 are often considered to
Angelika Sabine Bader +9 more
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Proteinopathy, oxidative stress and mitochondrial dysfunction: cross talk in alzheimer’s disease and parkinson’s disease [PDF]
, 2017 Alzheimer's disease and Parkinson's disease are two common neurodegenerative diseases of the elderly people that have devastating effects in terms of morbidity and mortality.
Chakrabarti, S. +3 more
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Frontiers in Molecular Neuroscience, 2023 Recent studies promote new interest in the intersectionality between autism spectrum disorder (ASD) and Alzheimer’s Disease. We have reported high levels of Amyloid-β Precursor Protein (APP) and secreted APP-alpha (sAPPa) and low levels of amyloid-beta ...
Deborah K. Sokol +2 more
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Molecules, 2020 Alzheimer’s disease (AD) is the most common form of dementia, characterized by chronic neuron loss and cognitive problems. Aggregated amyloid beta (Aβ) peptides, a product of cleaved amyloid precursor protein (APP) by beta-secretase 1 (BACE-1), have been
Uthaiwan Suttisansanee +5 more
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Self-Assembly and Anti-Amyloid Cytotoxicity Activity of Amyloid beta Peptide Derivatives [PDF]
Scientific Reports, 2017 AbstractThe self-assembly of two derivatives of KLVFF, a fragment Aβ(16–20) of the amyloid beta (Aβ) peptide, is investigated and recovery of viability of neuroblastoma cells exposed to Aβ (1–42) is observed at sub-stoichiometric peptide concentrations.
Castelletto, V. +13 more
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Investigation of low amyloid level toxicity effects on the function of hippocampal neurons
Open Life Sciences, 2015 Alzheimer disease (AD) is responsible for the majority of elderly dementia cases. There are multiple mouse models of AD, however, none of them completely recapitulate human pathology.
Popugaeva Elena +4 more
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NADPH oxidase as a therapeutic target in Alzheimer\u27s disease [PDF]
, 2008 At present, available treatments for Alzheimer\u27s disease (AD) are largely unable to halt disease progression. Microglia, the resident macrophages in the brain, are strongly implicated in the pathology and progressively degenerative nature of AD ...
Block, Michelle L
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Selective inhibition of phosphodiesterases 4, 5 and 9 induces HSP20 phosphorylation and attenuates amyloid beta 1-42 mediated cytotoxicity [PDF]
, 2016 Phosphodiesterase (PDE) inhibitors are currently under evaluation as agents that may facilitate the improvement of cognitive impairment associated with Alzheimer's disease. Our aim was to determine whether inhibitors of PDEs 4,5 and 9 could alleviate the
Baillie, George S. +4 more
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Abeta(1-42) induces abnormal alternative splicing of tau exons 2/3 in NGF-induced PC12 cells
Anais da Academia Brasileira de Ciências, 2014 Protein tau plays a pivotal role in the pathophysiology of Alzheimer's disease, where its hyperphos-phorylation promotes aggregation and microtubule destabilization.
TERESA LAGUNES +3 more
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