Results 11 to 20 of about 1,464,719 (336)
Molecular simulations of amyloid beta assemblies
Advances in Physics: X, 2020 Several neurodegenerative disorders arise from the abnormal protein aggregation in the nervous tissue leading tointracellular inclusions or extracellular aggregates in specific brain areas.
Gianvito Grasso, Andrea Danani
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The Beta Amyloid Dysfunction (BAD) Hypothesis for Alzheimer’s Disease
Frontiers in Neuroscience, 2019 Beta amyloid, Aβ 1–42, originally named as Amyloid A4 protein, is one of the most investigated peptides in neuroscience and has attracted substantial interest since its discovery as the main insoluble fibril-type protein in cerebrovascular amyloid ...
Heinz Hillen
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Amyloid-beta and tau protein beyond Alzheimer’s disease
Neural Regeneration Research, 2023 The aggregation of amyloid-beta peptide and tau protein dysregulation are implicated to play key roles in Alzheimer’s disease pathogenesis and are considered the main pathological hallmarks of this devastating disease. Physiologically, these two proteins
M. Abyadeh +13 more
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Amyloid Beta in Aging and Alzheimer’s Disease
International Journal of Molecular Sciences, 2022 Alzheimer’s disease (AD), is a progressive neurodegenerative disease that affects behavior, thinking, learning, and memory in elderly individuals. AD occurs in two forms, early onset familial and late-onset sporadic; genetic mutations in PS1, PS2, and ...
Ujala Sehar +4 more
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Microglia use TAM receptors to detect and engulf amyloid beta plaques
Nature Immunology, 2021 Two microglial TAM receptor tyrosine kinases, Axl and Mer, have been linked to Alzheimer’s disease, but their roles in disease have not been tested experimentally.
Youtong Huang +7 more
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Amyloid‐Beta Interaction with Mitochondria [PDF]
International Journal of Alzheimer’s Disease, 2011 Mitochondrial dysfunction is a hallmark of amyloid‐beta(Aβ)‐induced neuronal toxicity in Alzheimer′s disease (AD). The recent emphasis on the intracellular biology of Aβ and its precursor protein (AβPP) has led researchers to consider the possibility that mitochondria‐associated and/or intramitochondrial Aβ may directly cause neurotoxicity.
Pagani, Lucia, Eckert, Anne
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Small-angle X-ray scattering characterization of a $$\beta $$ β -amyloid model in phantoms
BMC Research Notes, 2020 Objective We present a method to prepare an amyloid model at scalable quantities for phantom studies to evaluate small-angle x-ray scattering systems for amyloid detection. Two amyloid models were made from a plasma protein with and without heating. Both
Sophya Breedlove +3 more
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The Roles of the Amyloid Beta Monomers in Physiological and Pathological Conditions
Biomedicines, 2023 Amyloid beta peptide is an important biomarker in Alzheimer’s disease, with the amyloidogenic hypothesis as one of the central hypotheses trying to explain this type of dementia.
Thomas Gabriel Schreiner +3 more
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Alzheimer's Research & Therapy, 2020 Blood-based biomarkers for Alzheimer’s disease (AD) might facilitate identification of participants for clinical trials targeting amyloid beta (Abeta) accumulation, and aid in AD diagnostics.
I. Verberk +15 more
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Synapses, synaptic activity and intraneuronal Aβ in Alzheimer's disease
Frontiers in Aging Neuroscience, 2010 β-amyloid peptide accumulation plays a central role in the pathogenesis of Alzheimer’s disease. Aberrant β-amyloid buildup in the brain has been shown to be present both in the extracellular space and within neurons.
Davide Tampellini
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