Results 71 to 80 of about 18,838 (278)

Cutaneous Phosphorylated Alpha‐Synuclein in Lewy Body Dementia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To determine the test performance of cutaneous phosphorylated alpha‐synuclein (P‐SYN) in dementia with Lewy bodies (DLB), individuals with reduced Montreal Cognitive Assessment (MoCA) and healthy controls. Methods This is the first subgroup analysis of the Synuclein‐One study, a prospective, blinded study evaluating P‐SYN detection ...
Christopher H. Gibbons, Todd Levine, Charles H. Adler, Bailey Bellaire, Ningshan Wang, Pinky Agarwal, Georgina M. Aldridge, Alexandru Barboi, Daniel Claassen, Virgilio G. H. Evidente, Douglas Galasko, Alejandra Gonzalez‐Duarte, Ramon Gil, Mark Gudesblatt, Stuart H. Isaacson, Horacio Kaufmann, Pravin Khemani, Rajeev Kumar, Guillaume Lamotte, Andy J. Liu, Nikolaus R. McFarland, Mitchell G. Miglis, Adam Reynolds, Gregory A. Sahagian, Marie‐Helene Saint‐Hilaire, Julie B. Schwartzbard, Wolfgang Singer, Michael J. Soileau, Steven Vernino, Patricio Millar Vernetti, Oleg Yerstein, Roy Freeman   +31 more
wiley   +1 more source

NACore Amyloid Formation in the Presence of Phospholipids

Frontiers in Physiology, 2020
Amyloids are implicated in many diseases, and disruption of lipid membrane structures is considered as one possible mechanism of pathology. In this paper we investigate interactions between an aggregating peptide and phospholipid membranes, focusing on ...
Jon Pallbo, Masayuki Imai, Luigi Gentile, Shin-ichi Takata, Ulf Olsson, Emma Sparr   +5 more
doaj   +1 more source

Membrane protein remodeling in microglia exposed to amyloid peptides [PDF]

, 2016
Infection, neurodegeneration, and other conditions associated with loss of brain homeostasis, induce changes in microglial morphology, gene expression and function, generally referred to as “activation”.
Correani, Virginia, Fabrizi, Cinzia, Francesco, Laura Di, Fumagalli, Lorenzo, Maras, Bruno, Mignogna, Giuseppina, Pompili, Elena, Schinina', Maria Eugenia   +7 more
core  

Bacterial curli protein promotes the conversion of PAP248-286 into the amyloid SEVI: cross-seeding of dissimilar amyloid sequences [PDF]

, 2013
Fragments of prostatic acid phosphatase (PAP248-286) in human semen dramatically increase HIV infection efficiency by increasing virus adhesion to target cells.
Apostol, Arnold, Auer, Barnhart, Cabaleiro-Lago, Capule, Cegelski, Chien, Cloe, Cohen, Colletier, Dobson, Dzwolak, Eisenberg, Foo, Gerard, Gervaix, Giehm, Hammer, Han, Hauber, Hinz, Horvath, Jarrett, Jordal, Kim, Knowles, Krebs, Linse, Little, Ma, MacPhee, Manzoni, Martellini, Miklossy, Miklossy, Morales, Munch, Naiki, Olsen, Olsen, Olzscha, Ono, O’Nuallain, Padrick, Perelson, Pronchik, Rajan, Roan, Roan, Roan, Sawaya, Siddiqua, Suzuki, Thomas, Thurman, Tukel, Wang, Wang, Wasmer, Westermark, Wiltzius, Wurm, Xue, Yagi, Ye, Yin, Yu   +67 more
core   +1 more source

Neuropsychiatric Symptoms Mimicking Dementia in a Patient Treated With Imatinib

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Tyrosine kinase inhibitors are the cornerstone of chronic myeloid leukemia treatment. Newer agents have more potency and a broader spectrum of action, but also a higher potential for neuropsychiatric side effects. We present a case of a patient on imatinib who developed progressive cognitive, mood, and behavioral alterations.
Ashley Jones, Samuele Bonomi, Keith E. Stockerl‐Goldstein, Randall J. Bateman   +3 more
wiley   +1 more source

Amyloidosis-history and development, emphasis on insulin and prion amyloids

Brain Disorders
Amyloidosis is associated with misfolding of protein (normal functional and cellular) into intractable aggregates, commonly known as amyloid fibrils.
Sanjay Kisan Metkar, Saranya Udayakumar, Agnishwar Girigoswami, Koyeli Girigoswami   +3 more
doaj   +1 more source

Yeast Models for Amyloids and Prions: Environmental Modulation and Drug Discovery

Molecules, 2019
Amyloids are self-perpetuating protein aggregates causing neurodegenerative diseases in mammals. Prions are transmissible protein isoforms (usually of amyloid nature).
Tatiana A. Chernova, Yury O. Chernoff, Keith D. Wilkinson   +2 more
doaj   +1 more source

Hsp40s play complementary roles in the prevention of tau amyloid formation

eLife, 2021
The microtubule-associated protein, tau, is the major subunit of neurofibrillary tangles associated with neurodegenerative conditions, such as Alzheimer's disease.
Rose Irwin, Ofrah Faust, Ivana Petrovic, Sharon Grayer Wolf, Hagen Hofmann, Rina Rosenzweig   +5 more
doaj   +1 more source

Functional characterization of TasA and TapA in the formation of the amyloid fiber in Bacillus subtilis [PDF]

, 2017
Introduction Functional amyloids are a very heterogeneous family of amyloid proteins widespread in nature, from humans to bacteria. Unlike their “pathogenic” relatives, implicated in several neurodegenerative diseases, functional amyloids play important
Conejero-Lara, Francisco, Cámara-Almirón, Jesús, Morel, Bertrand, Romero, Diego   +3 more
core  

Unified perspective on proteins: A physics approach

, 2004
We study a physical system which, while devoid of the complexity one usually associates with proteins, nevertheless displays a remarkable array of protein-like properties. The constructive hypothesis that this striking resemblance is not accidental leads
Banavar, Jayanth R., Hoang, Trinh Xuan, Maritan, Amos, Seno, Flavio, Trovato, Antonio   +4 more
core   +1 more source