Results 61 to 70 of about 11,917 (183)

Intergenerational Transmission of Metabolic Changes in Oocytes From Aged Mice

Aging Cell, Volume 25, Issue 3, March 2026.
This study shows that oxidative changes in oocytes from aged female mice lead to lipid droplet accumulation and altered energy and retinoid metabolism. These changes persist in embryonic organs, triggering antioxidant responses in lipid‐rich tissues. Remarkably, altered profiles are transmitted across generations, reaching third generation, suggesting ...
Hafsa Gulzar, Richard Musson, Simona Bisogno, Lulu Alluhaibi, Alexey Maximenko, Ewelina Bik, Małgorzata Barańska, Joanna Depciuch, Grażyna E. Ptak   +8 more
wiley   +1 more source

Chemical synthesis, pharmacological characterization, and possible formation in unicellular fungi of 3-hydroxy-anandamide1

Journal of Lipid Research, 2009
The fungal pathogen Candida albicans transforms arachidonic acid (AA) into 3-hydroxyarachidonic acid [3(R)-HETE], and we investigated if its nonpathogenic and 3(R)-HETE-producing close relative, Dipodascopsis uninucleata, could similarly transform the ...
L. De Petrocellis, R. Deva, F. Mainieri, M. Schaefer, T. Bisogno, R. Ciccoli, A. Ligresti, K. Hill, S. Nigam, G. Appendino, V. Di Marzo   +10 more
doaj   +1 more source

Anxiofit‐1 and reduction of subthreshold and mild anxiety: Evaluation of a health claim pursuant to article 14 of regulation (EC) No 1924/2006

EFSA Journal, Volume 24, Issue 3, March 2026.
Abstract Following an application from Anxiofit Ltd. pursuant to Article 14 of Regulation (EC) No 1924/2006 via the Competent Authority of Hungary, the EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) was asked for an opinion on the scientific substantiation of a health claim related to Anxiofit‐1 and reduction of subthreshold and mild ...
EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA), Dominique Turck, Torsten Bohn, Montaña Cámara, Jacqueline Castenmiller, Stefaan de Henauw, Karen‐Ildico Hirsch‐Ernst, Angeles Jos, Alexandre Maciuk, Inge Mangelsdorf, Breige McNulty, Androniki Naska, Kristina Pentieva, Frank Thies, Ines Drenjančević, Ionut Craciun, Alfonso Siani   +17 more
wiley   +1 more source

Plasma endocannabinoid alterations in individuals with substance use disorder are dependent on the mirror effect of schizophrenia

Frontiers in Psychiatry, 2012
Schizophrenia is a complex psychiatric disorder strongly associated with substance use disorders. Theoretically, schizophrenia and SUD may share endocannabinoid alterations in the brain reward system.
Joelle eDesfossés, Emmanuel eStip, Lahcen eAit Bentaleb, Olivier eLipp, Jean-Pierre eChiasson, Alexandra eFurtos, Karine eVenne, Edouard eKouassi, Stephane ePotvin   +8 more
doaj   +1 more source

Unraveling Endocannabinoid Signaling Pathways in Cisplatin‐Induced Ototoxicity

The FASEB Journal, Volume 40, Issue 4, 28 February 2026.
We performed a comprehensive molecular profiling of the endocannabinoid (eCB) system (ECS) in an auditory Hair cell (HC)‐like cell line (1). Afterwards, we developed suitable in vitro and in vivo models of cisplatin‐induced ototoxicity where we identified distinct components of the ECS (CB2R, DAGLβ and ABHD6) as molecular targets of the drug (2 ...
Sakthimala Palaniappan, Annamaria Tisi, Camilla Di Meo, Cristina Urbano, Georgina E. Fenton, Francesco Della Valle, Federico Fanti, Dario Compagnone, Marc Nazarè, Huib Versnel, Andrea Aramini, Marcello Allegretti, Mauro Maccarrone   +12 more
wiley   +1 more source

Altered Anandamide Degradation in Attention Deficit Hyperactivity Disorder

Pediatric Neurology Briefs, 2009
Anandamide (AEA) metabolism was investigated in 15 drug-free boys with ADHD (aged 6.5-13 years) and 15 age- and gender-matched healthy controls, in a study at Universita Tor Vergata, Rome, Italy.
J Gordon Millichap
doaj   +1 more source

Pharmacological characterization of a novel, potent, selective, and orally active fatty acid amide hydrolase inhibitor, PKM‐833 [(R)‐N‐(pyridazin‐3‐yl)‐4‐(7‐(trifluoromethyl)chroman‐4‐yl)piperazine‐1‐carboxamide] in rats: Potential for the treatment of inflammatory pain

Pharmacology Research & Perspectives, 2020
Recently, we identified a novel fatty acid amide hydrolase (FAAH) inhibitor, PKM‐833 [(R)‐N‐(pyridazin‐3‐yl)‐4‐(7‐(trifluoromethyl)chroman‐4‐yl)piperazine‐1‐carboxamide].
Toshiya Endo, Takashi Takeuchi, Shunsuke Maehara   +2 more
doaj   +1 more source

Moving bliss: a new anandamide transporter

Nature Neuroscience, 2011
A study now identifies a protein that mediates the cellular transport of the lipophilic endocannabinoid anandamide in aqueous environments.
Marsicano G, Chaouloff F.
openaire   +2 more sources

Novel Technologies for Exploring the Skin–Brain Axis

Advanced Sensor Research, Volume 5, Issue 2, February 2026.
The skin–brain axis mediates bidirectional communication between cutaneous physiology and the nervous system, influencing sensation, inflammation, and disease. This review surveys emerging microsensor, nanosensor, and bioelectronic technologies integrated with advanced skin and neural models, highlighting multimodal, real‐time strategies to decode ...
Dahiana Mojena Medina, Francesca Santoro
wiley   +1 more source

The Endocannabinoid System as a Potential Therapeutic Target for Pain Modulation

Balkan Medical Journal, 2014
Although cannabis has been used for pain management for millennia, very few approved cannabinoids are indicated for the treatment of pain and other medical symptoms. Cannabinoid therapy re-gained attention only after the discovery of endocannabinoids and
Ahmet Ulugöl
doaj   +1 more source