Results 71 to 80 of about 17,707 (220)
Evidence for the intracellular accumulation of anandamide in adiposomes
, 2008 Anandamide is a lipid messenger that carries out a wide variety of biological functions. It has been suggested that anandamide accumulation involves binding to a saturable cellular component.
ODDI, Sergio +7 more
core +2 more sources
The Journal of Physiology, EarlyView.Abstract figure legend THC and extract administered to diet‐induced obese mice reduced body weight and fat storage. Extract, but not THC, improved glucose clearance by a mechanism that may include restoring adipoinsular function. Abstract Diet‐induced obesity (DIO) is associated with dysregulated adipoinsular axis and endocannabinoid system (eCBS ...
Bryant Avalos +7 more
wiley +1 more source
Anandamide increases swelling and reduces calcium sensitivity of mitochondria
, 2009 The endocannabinoid anandamide alters mitochondria-dependent signal transduction, thus controlling key cellular events like energy homeostasis and induction of apoptosis.
ODDI, Sergio +3 more
core +2 more sources
Endocannabinoids and related N-acylethanolamines: biological activities and metabolism
Inflammation and Regeneration, 2018 The plant Cannabis sativa contains cannabinoids represented by Δ9-tetrahydrocannabinol, which exert psychoactivity and immunomodulation through cannabinoid CB1 and CB2 receptors, respectively, in animal tissues. Arachidonoylethanolamide (also referred to
Kazuhito Tsuboi +3 more
doaj +1 more source
Anandamide and vanilloid TRPV1 receptors [PDF]
British Journal of Pharmacology, 2003 A large body of evidence now exists to substantiate that the endocannabinoid, anandamide, activates TRPV1 receptors. It is a low intrinsic efficacy TRPV1 agonist that behaves as a partial agonist in tissues with a low receptor reserve, while in tissues with high receptor reserve and in circumstances associated with certain disease states, it behaves as
openaire +2 more sources
British Journal of Pharmacology, Volume 183, Issue 20, Page 6132-6153, October 2026.Abstract Background and Purpose Positive allosteric modulators (PAMs) engage sites distinct from the orthosteric CB1 cannabinoid receptor binding site. GAT211, a racemic ligand, contains GAT228 (R) and GAT229 (S) enantiomers. Whether enantiomer‐mediated differences in allosteric activation or positive allosteric modulation translate into differences in
Ifeoluwa D. Solomon +3 more
wiley +1 more source
Molecular modeling of anandamide-cholesterol interactions.
, 2013 A- Spacefill model of a cholesterol-anandamide complex in vacuo obtained with the Polak-Ribiere algorithm (for geometry optimization) and then submitted to Monte Carlo simulations.
Jacques Fantini (367498) +3 more
core +1 more source
Altered Anandamide Degradation in Attention Deficit Hyperactivity Disorder
Pediatric Neurology Briefs, 2009 Anandamide (AEA) metabolism was investigated in 15 drug-free boys with ADHD (aged 6.5-13 years) and 15 age- and gender-matched healthy controls, in a study at Universita Tor Vergata, Rome, Italy.
J Gordon Millichap
doaj +1 more source
Pharmacology Research & Perspectives, 2020 Recently, we identified a novel fatty acid amide hydrolase (FAAH) inhibitor, PKM‐833 [(R)‐N‐(pyridazin‐3‐yl)‐4‐(7‐(trifluoromethyl)chroman‐4‐yl)piperazine‐1‐carboxamide].
Toshiya Endo +2 more
doaj +1 more source
Brain and Behavior, Volume 16, Issue 9, September 2026.Among patients hospitalized for major depressive disorder, a positive THC urine drug screen was not independently associated with 30‐day psychiatric readmission or hospital length of stay. These findings suggest that patient factors beyond THC exposure may have a greater influence on hospitalization outcomes.
Mohammed E. Khedr +4 more
wiley +1 more source