Results 81 to 90 of about 17,707 (220)

A catalytically silent FAAH-1 variant drives anandamide transport in neurons. [PDF]

, 2012
The endocannabinoid anandamide is removed from the synaptic space by a selective transport system, expressed in neurons and astrocytes, that remains molecularly uncharacterized.
Lodola A., Mor M., Cavalli A, Garau G, CAVALLI, ANDREA, Piomelli D, Masetti M, Sasso O., Reggiani A, Bertorelli R., Bottegoni G, Lodola A, Fu J., Sasso O, Reggiani A., Armirotti A., Piomelli D., Guijarro A, Rocchia W, Bandiera T, Bottegoni G., Mor M, Armirotti A, Rocchia W., Bandiera T., Fu J, Guijarro A., Bertorelli R, MASETTI, MATTEO, Garau G.   +29 more
core   +2 more sources

The Endocannabinoid System as a Potential Therapeutic Target for Pain Modulation

Balkan Medical Journal, 2014
Although cannabis has been used for pain management for millennia, very few approved cannabinoids are indicated for the treatment of pain and other medical symptoms. Cannabinoid therapy re-gained attention only after the discovery of endocannabinoids and
Ahmet Ulugöl
doaj   +1 more source

A Super‐Resolution Approach for Astrocyte‐Specific Molecular Imaging Reveals the Nanoscale Distribution of Monoacylglycerol Lipase, the Metabolic Node Between Endocannabinoid and Prostaglandin Signaling

Glia, Volume 74, Issue 9, September 2026.
Dual‐color STORM resolves the precise architecture and protein distributions within hippocampal astrocytes at the nanoscale. Identification of a sparse but specific MAGL pool in CA1 astrocytic processes. Astrocytic MAGL is not synapse‐associated, suggesting a synapse‐independent role.
Miklós Zöldi, István Katona
wiley   +1 more source

Oxyradical Stress, Endocannabinoids, and Atherosclerosis

Toxics, 2015
Atherosclerosis is responsible for most cardiovascular disease (CVD) and is caused by several factors including hypertension, hypercholesterolemia, and chronic inflammation.
Anberitha T. Matthews, Matthew K. Ross
doaj   +1 more source

Metabolic Syndrome: From Mechanisms to Therapeutic Interventions

MedComm, Volume 7, Issue 9, September 2026.
A comprehensive overview of molecular mechanisms delves into the potential disease mechanisms of metabolic syndrome, including complex mechanisms such as insulin resistance, chronic low‐grade inflammation, oxidative stress, and epigenetic modifications, and how these mechanisms contribute to the development of metabolic syndrome. Here, the relationship
Mengyao Yan, Qian Xiang
wiley   +1 more source

Vaccenic acid suppresses intestinal inflammation by increasing anandamide and related N-acylethanolamines in the JCR:LA-cp rat[S]

Journal of Lipid Research, 2016
Vaccenic acid (VA), the predominant ruminant-derived trans fat in the food chain, ameliorates hyperlipidemia, yet mechanisms remain elusive. We investigated whether VA could influence tissue endocannabinoids (ECs) by altering the availability of their ...
Miriam Jacome-Sosa, Claudia Vacca, Rabban Mangat, Abdoulaye Diane, Randy C. Nelson, Martin J. Reaney, Jianheng Shen, Jonathan M. Curtis, Donna F. Vine, Catherine J. Field, Miki Igarashi, Daniele Piomelli, Sebastiano Banni, Spencer D. Proctor   +13 more
doaj   +1 more source

Tuning the oviduct to the anandamide tone [PDF]

Journal of Clinical Investigation, 2006
Anandamide (N-arachidonoylethanolamide) is a lipid signal molecule that was the first endogenous agonist for cannabinoid receptors to be discovered. Cannabinoid receptor type 1 (CB1) is widely distributed in neurons and nonneuronal cells in brain and peripheral organs including sperm, eggs, and preimplantation embryos. A study by Wang and colleagues in
openaire   +2 more sources

UK Medical Cannabis Registry: A Clinical Outcomes Analysis for Autism Spectrum Disorder

Neuropsychopharmacology Reports, Volume 46, Issue 3, September 2026.
A case series studying outcomes up to 18 months in autistic patients from the UK Medical Cannabis Registry. ABSTRACT Introduction Autism spectrum disorder (ASD) is a neurodevelopmental disorder associated with distressed behaviors and psychological challenges.
Arushika Aggarwal, Simon Erridge, Madhur Varadpande, Evonne Clarke, Katy McLachlan, Ross Coomber, Muhammed Asghar, Urmila Bhoskar, Matthieu Crews, Andrea De Angelis, Muhammad Imran, Fariha Kamal, Laura Korb, Gracia Mwimba, Simmi Sachdeva‐Mohan, Gabriel Shaya, James J. Rucker, Mikael H. Sodergren   +17 more
wiley   +1 more source

The Endocannabinoid Anandamide : Metabolism & Neuroprotection [PDF]

, 2002
Marijuana is an extract of the Cannabis sativa and is the most used illegal drug in the world. Public debate centres upon the possible legalization of marijuana for recreational and therapeutic uses.
Stelt, Marcelis van der
core   +20 more sources

Psychiatric effects of cannabidiol, cannabinol, and tetrahydrocannabinol: A narrative review of clinical evidence and risk profiles

Psychiatry and Clinical Neurosciences Reports, Volume 5, Issue 3, September 2026.
Abstract Cannabinoid products are increasingly used worldwide despite limited psychiatric evidence. This narrative review synthesizes preclinical and clinical evidence on cannabidiol (CBD), cannabinol (CBN), and tetrahydrocannabinol (THC) to clarify their distinct psychiatric profiles and discuss how current evidence may inform ongoing clinical and ...
Yasuhiro Kishi, Ichiro Takumi, Kakusho Chigusa Nakajima‐Ohyama   +2 more
wiley   +1 more source