Results 151 to 160 of about 107,653,743 (272)
Diabetes, Obesity and Metabolism, Volume 28, Issue 11, Page 10183-10194, November 2026.ABSTRACT Aims To further characterise the effects of retatrutide on cardiometabolic risk, lipoprotein and inflammatory biomarkers were assessed post hoc in phase 2 trials of adults with obesity/overweight with or without type 2 diabetes (T2D). Materials and Methods Data were analysed from two randomised, double‐blind, placebo‐controlled phase 2 trials.
Giacomo Ruotolo +13 more
wiley +1 more source
Diabetes, Obesity and Metabolism, Volume 28, Issue 11, Page 10428-10438, November 2026.ABSTRACT Background Genetic clusters related to Type 2 diabetes (T2D) have differential impact on cardiovascular diseases (CVDs), although the underlying mechanisms, such as proteomic perturbation, remain unexplored. We conducted a network Mendelian randomisation (MR) study to identify proteomic mediators linking T2D genetic clusters and CVDs.
Shuang Liao +4 more
wiley +1 more source
Hypocholesterolemia in liver and cardiovascular disease: Friend or foe?
Journal of Internal Medicine, Volume 300, Issue 5, Page 572-589, November 2026.Abstract Hypocholesterolemia is perceived as benign given its association with lower cardiovascular risk. However, genetic and epidemiological evidence indicates that persistently low levels of low‐density lipoprotein cholesterol (LDL‐C) and apolipoprotein B (ApoB) arise from distinct biological mechanisms with different hepatic implications ...
Valentina Flagiello +3 more
wiley +1 more source
The FASEB Journal, Volume 40, Issue 20, 31 October 2026.Blood samples from pregnant heifers carrying in vitro‐produced embryos were analyzed for RNA‐sequencing to test whether maternal blood transcriptome could be predictive of large offspring syndrome, stillbirth, and abortion compared with controls.
Tatiane S. Maia +8 more
wiley +1 more source
Fusogenic RNA Nanomodules for Fusion‐Mediated and Multiplexed siRNA Delivery
Advanced Functional Materials, Volume 36, Issue 86, 26 October 2026.A fusogenic lipid‐layered RNA nanomodules (L‐CRAMs) enable high‐capacity and long‐lasting siRNA delivery through membrane fusion. These nanomodules carry exceptionally large siRNA payloads, avoid conventional endosomal uptake, and release multiple functional siRNAs through Dicer‐mediated processing.
Sunghyun Moon +5 more
wiley +1 more source
From Molecular Targets to Advanced Delivery Systems: Aptamers for Precision Ocular Therapeutics
Advanced Therapeutics, Volume 9, Issue 10, October 2026.Aptamer‐based strategies are revolutionizing ocular disease management through highly specific molecular recognition of disease specific molecular targets. This review systematically integrates therapeutic aptamer sequences, diagnostic aptasensor platforms, and targeted delivery strategies, highlighting design principles, ocular bioavailability ...
Minal Thacker +4 more
wiley +1 more source
Angiopoietin-1 Is Required for Vortex Vein and Choriocapillaris Development in Mice. [PDF]
Arterioscler Thromb Vasc Biol, 2022 Liu P +4 more
europepmc +1 more source
Advanced Science, Volume 13, Issue 58, 19 October 2026.In diabetic kidney disease, elevated podocyte ANGPTL4 is linked to reduced TFEB nuclear localization and compromised lysosomal degradative function. These changes impair podocyte lipophagy and promote lipid‐droplet accumulation and podocyte injury, which may contribute to renal injury progression.
Xiaojing Liu +7 more
wiley +1 more source
Angiopoietin-1: an early biomarker of diabetic nephropathy? [PDF]
J Transl Med, 2021 Butler AE +3 more
europepmc +1 more source