Results 81 to 90 of about 107,653,743 (272)

The effect of targeting Tie2 on hemorrhagic shock-induced renal perfusion disturbances in rats

Intensive Care Medicine Experimental, 2021
Background Hemorrhagic shock is associated with acute kidney injury and increased mortality. Targeting the endothelial angiopoietin/Tie2 system, which regulates endothelial permeability, previously reduced hemorrhagic shock-induced vascular leakage.
Anoek L. I. van Leeuwen, Nicole A. M. Dekker, Paul Van Slyke, Esther de Groot, Marc G. Vervloet, Joris J. T. H. Roelofs, Matijs van Meurs, Charissa E. van den Brom   +7 more
doaj   +1 more source

Circulating serum levels of angiopoietin-1 and angiopoietin-2 in nasopharynx and larynx carcinoma patients

, 2016
We aimed to determine the serum levels of angiogenic factors, namely angiopoietins, in nasopharyngeal and laryngeal carcinoma patients. We also aimed to seek the relation of these molecules with tumor grade and their utility as diagnostic biomarkers.
Serilmez, Murat, Karadeniz, Ahmet, Soydinc, Hilal Oguz, Yasasever, Vildan, Guveli, Murat Emin, Duranyildiz, Derya, Bilgin, Elif   +6 more
core   +1 more source

Inconsistent Transcriptomic Responses to Hexabromocyclododecane in Japanese Quail: A Comparative Analysis of Results From Four Different Study Designs

Environmental Toxicology and Chemistry, EarlyView.
Abstract Efforts to use transcriptomics for toxicity testing have classically relied on the assumption that chemicals consistently produce characteristic transcriptomic signatures that are reflective of their mechanism of action. However, the degree to which transcriptomic responses are conserved across different test methodologies has seldom been ...
Paul Béziers, Elena Legrand, Emily Boulanger, Niladri Basu, Jessica D. Ewald, Paula Henry, Markus Hecker, Jianguo Xia, Natalie Karouna‐Renier, Doug Crump, Jessica Head   +10 more
wiley   +1 more source

Endothelin-1/Endothelin Receptor Type A-Angiopoietins/Tie-2 Pathway in Regulating the Cross Talk Between Glomerular Endothelial Cells and Podocytes in Trichloroethylene-Induced Renal Immune Injury

Journal of Inflammation Research, 2021
Haibo Xie,1,2,* Hui Wang,1,2,* Qifeng Wu,3 Jiale Peng,4 Hua Huang,4 Yican Wang,4 Meng Huang,4 Wei Jiang,4 Yi Yang,4 Xuesong Zhang,4 Jiaxiang Zhang,2,4 Qixing Zhu1,2 1Department of Dermatology, First Affiliated Hospital of Anhui Medical University, Hefei,
Xie H, Wang H, Wu Q, Peng J, Huang H, Wang Y, Huang M, Jiang W, Yang Y, Zhang X, Zhang J, Zhu Q   +11 more
doaj  

Angiopoietin-2 is required for postnatal angiogenesis and lymphatic patterning, and only the latter role is rescued by Angiopoietin-1.

, 2002
VEGF and Angiopoietin-1 requisitely collaborate during blood vessel development. While Angiopoietin-1 obligately activates its Tie2 receptor, Angiopoietin-2 can activate Tie2 on some cells, while it blocks Tie2 activation on others.
Witte, MH, Witte, C, Campochiaro, PA, Renard, R, Martin, C, Gale, NW, McClain, J, Hackett, SF, Suri, C, Wiegand, SJ, Thurston, G, Yancopoulos, GD, Jackson, D, Wang, Q, Jackson, David   +14 more
core   +1 more source

The association of angiogenic factors and chronic kidney disease

BMC Nephrology, 2018
Background There are limited data on the associations of circulating angiogenic factors with chronic kidney disease (CKD). We investigate the associations of circulating vascular endothelial growth factor (VEGF)-A, angiopoietin-1, angiopoietin-1/VEGF-A ...
Christopher E. Anderson, L. Lee Hamm, Gem Batuman, Damodar R. Kumbala, Chung-Shiuan Chen, Swapna G. Kallu, Ravi Siriki, Shilpa Gadde, Myra A. Kleinpeter, N. Kevin Krane, Eric E. Simon, Jiang He, Jing Chen   +12 more
doaj   +1 more source

Angiopoietins stimulate pancreatic islet development from stem cells

Scientific Reports, 2021
In vitro differentiation of human induced pluripotent stem cells (iPSCs) into functional islets holds immense potential to create an unlimited source of islets for diabetes research and treatment.
Soujanya S. Karanth, Shuofei Sun, Huanjing Bi, Kaiming Ye, Sha Jin   +4 more
doaj   +1 more source

Serum angiopoietin-1 as a prognostic marker in resected early stage lung cancer.

, 2009
PURPOSE: We evaluated the clinical significance of angiopoietins and vascular endothelial growth factor (VEGF) in patients with resected early stage lung cancer.
Lee, KB, Park, KJ, Park, JH, Kim, YS, Choi, JH, Chung, WY, Lee, HL, Choi, H, Hwang, SC, Sheen, SS, Kim, YB, Lee, S, Lee, KS   +12 more
core   +1 more source

Bisphenol A and Its Analogs: Toxicity Analysis in Mouse and Rat Liver—A Review

Journal of Applied Toxicology, EarlyView.
ABSTRACT Bisphenol A (BPA) and its analogs are widely recognized for their use in industry and plastic manufacturing. Consequently, humans and animals are continually exposed to various substances in their daily lives. This review evaluates the hepatic toxicity of BPA and its analogs in mice and rats, with particular emphasis on molecular mechanisms ...
Sevda Bagdatli, Muhammed Canik, Gizem Gencay, Nurbanu Zengin, Tarık Dinc, Nazan Deniz Yön   +5 more
wiley   +1 more source

Angiopoietin-1 and Pulmonary Hypertension [PDF]

Circulation Research, 2003
Our very existence depends on the air that we breathe, as well as the remarkable systems that have evolved to ensure that the oxygen we take into our lungs is efficiently delivered to the rest of the body via the bloodstream. When these systems begin to fail, life itself can become quite tenuous.
J.S. Rudge, G. Thurston, G.D. Yancopoulos   +2 more
openaire   +1 more source