Results 61 to 70 of about 311,191 (157)

Peran Angiotensin 1-7 pada Penyakit Ginjal Kronik

Jurnal Ilmu Kesehatan Indonesia
Latar Belakang:  Penyakit ginjal kronik (PGK) ditandai penurunan progresif fungsi ginjal. Pada patogenesisnya, sistem renin–angiotensin–aldosteron (RAAS) berperan sentral.
Dinda Putri Sofiani, Harnavi Harun
doaj   +1 more source

The structure of testis angiotensin-converting enzyme (tACE-g13) in complex with the inhibitor RXPA380

, 2006
Includes bibliographical references.Angiotensin-converting enzyme (ACE), a zinc metalloprotease, is a key regulator of the mammalian renin-angiotensin system (RAS) Primarily, ACF is a dipeptidl peptidase which cleaves angiotensin I to produce angiotensin
Chitapi, Itai
core  

Hepatic Mitochondrial Renin-Angiotensin Systems

, 2015
Introduction: The circulating renin-angiotensin system (RAS) was originally described as a key endocrine regulator of intravascular homeostasis; however, the existence of a local (tissue) RAS has become increasingly reported in a variety of tissues ...
Skipworth, JRA
core  

Role of the vasodilator peptide angiotensin-(1–7) in cardiovascular drug therapy

, 2007
Christoph Schindler1, Peter Bramlage1, Wilhelm Kirch1, Carlos M Ferrario21Institute of Clinical Pharmacology, Medical Faculty, Technical University of Dresden, Dresden, Germany; 2Hypertension and Vascular Disease Center, Wake Forest University, School of
Carlos M Ferrario, Christoph Schindler, Wilhelm Kirch, Peter Bramlage   +3 more
core  

Therapeutic uses for Angiotensin-(1-7)

, 2016
Angiotensin-(1-7) is a key component of the Renin-Angiotensin System, which can counter-regulate several deleterious effects caused by angiotensin II. Due to the potential for therapeutic use, several of its actions are specifically described in patents.
Sinisterra, Rubén Dario, Passos-Silva, Danielle, Machado-Silva, Alice, Santos, Robson Augusto   +3 more
core   +1 more source

Reverse translation of phase I biomarker findings links the activity of angiotensin-(1–7) to repression of hypoxia inducible factor-1α in vascular sarcomas

BMC Cancer, 2012
Background In a phase I study of angiotensin-(1–7) [Ang-(1–7)], clinical benefit was associated with reduction in plasma placental growth factor (PlGF) concentrations. The current study examines Ang-(1–7) induced changes in biomarkers according to cancer
Petty W, Aklilu Mebea, Varela Victor A, Lovato James, Savage Paul D, Miller Antonius A   +5 more
doaj   +1 more source

Protein-protein interactions of human somatic angiotensin-converting enzyme

, 2011
In this study, novel disulphide bridges were engineered into the linker region of ACE [Angiotensin-converting enzyme] in an attempt to limit inter-domain movement, thereby producing a candidate for crystallisation and to determine the effect of these ...
Gordon, Kerry
core  

Novel players in cardioprotection: Insulin like growth factor-1, angiotensin-(1-7) and angiotensin-(1-9)

, 2015
Artículo de publicación ISIInsulin-like growth factor-1, angiotensin-(1-7) and angiotensin-(1-9) have been proposed to be important mediators in cardioprotection. A large body of evidence indicates that insulin like growth factor-1 has pleotropic actions
Paz Ocaranza, María, García, Lorena, Ocaranza, María Paz, Chiong Lay, Mario Martín, Bustamante, Mario, Lavandero González, Sergio, Chiong Lay, Mario, Pavez, Mario, García Nannig, Lorena, Westermeier, Francisco   +9 more
core   +1 more source

Angiotensin-(1-7): Pharmacological properties and pharmacotherapeutic perspectives

, 2008
Therapeutic modulation of the renin-angiotensin system is not complete without taking into consideration the beneficial effects of angiotensin-(1-7) in cardiovascular pathology.
Dilek Iusuf, van Gilst, WH, Roks, Anton, Robert H. Henning, Roks, Anton J. M., Anton J.M. Roks, Iusuf, Dilek, Henning, Robert H., Roks, Anton; id_orcid, van Gilst, Wiek H., Wiek H. van Gilst, Iusuf, D, Henning, RH   +12 more
core   +1 more source

Angiotensin‐converting enzyme 2 deficiency accelerates and angiotensin 1‐7 restores age‐related muscle weakness in mice

Journal of Cachexia, Sarcopenia and Muscle, 2018
Background A pharmacologic strategy for age‐related muscle weakness is desired to improve mortality and disability in the elderly. Angiotensin‐converting enzyme 2 (ACE2) cleaves angiotensin II into angiotensin 1‐7, a peptide known to protect against ...
Hikari Takeshita, Koichi Yamamoto, Satoko Nozato, Masao Takeda, So‐ichiro Fukada, Tadakatsu Inagaki, Hirotsugu Tsuchimochi, Mikiyasu Shirai, Yoichi Nozato, Taku Fujimoto, Yuki Imaizumi, Serina Yokoyama, Motonori Nagasawa, Go Hamano, Kazuhiro Hongyo, Tatsuo Kawai, Hiroko Hanasaki‐Yamamoto, Shuko Takeda, Toshimasa Takahashi, Hiroshi Akasaka, Norihisa Itoh, Yoichi Takami, Yasushi Takeya, Ken Sugimoto, Hironori Nakagami, Hiromi Rakugi   +25 more
doaj   +1 more source