Results 41 to 50 of about 362,216 (339)

NADPH-Oxidase, Rho-Kinase and Autophagy Mediate the (Pro)renin-Induced Pro-Inflammatory Microglial Response and Enhancement of Dopaminergic Neuron Death

Antioxidants, 2021
Dysregulation of the tissue renin–angiotensin system (RAS) is involved in tissue oxidative and inflammatory responses. Among RAS components, renin, its precursor (pro)renin and its specific receptor (PRR) have been less investigated, particularly in the ...
Andrea Lopez-Lopez, Begoña Villar-Cheda, Aloia Quijano, Pablo Garrido-Gil, María Garcia-Garrote, Carmen Díaz-Ruiz, Ana Muñoz, José L. Labandeira-Garcia   +7 more
doaj   +1 more source

Modeling the molecular impact of SARS-CoV-2 infection on the renin-angiotensin system [PDF]

arXiv, 2020
SARS-CoV-2 coronavirus infection is mediated by the binding of its spike protein to the angiotensin-converting enzyme 2 (ACE2), which plays a pivotal role in the renin-angiotensin system (RAS). The study of RAS dysregulation due to SARS-CoV-2 infection is fundamentally important for a better understanding of the pathogenic mechanisms and risk factors ...
arxiv  

A Dual‐Layer Hydrogel Barrier Integrating Bio‐Adhesive and Anti‐Adhesive Properties Prevents Postoperative Abdominal Adhesions

Advanced Healthcare Materials, EarlyView.
A new dual‐layer hydrogel barrier for preventing postoperative abdominal adhesions is developed. The inner layer, consisting of polyethyleneimine (PEI) and thioctic acid (TA), enhanced adhesion to moist tissues. The outer layer combines zwitterionic, thermoresponsive hyaluronic acid with anti‐inflammatory epigallocatechin gallate (EGCG) and forms a ...
Mena Asha Krishnan, Olawale A. Alimi, Mitchell Kuss, Tiffany N Razabdouski, Erika A Eksioglu, Bin Duan, Bo Liu   +6 more
wiley   +1 more source

ACE2, Much More Than Just a Receptor for SARS-COV-2

Frontiers in Cellular and Infection Microbiology, 2020
The rapidly evolving pandemic of severe acute respiratory syndrome coronavirus (SARS-CoV-2) infection worldwide cost many lives. The angiotensin converting enzyme-2 (ACE-2) has been identified as the receptor for the SARS-CoV-2 viral entry.
Lobelia Samavati, Lobelia Samavati, Bruce D. Uhal   +2 more
doaj   +1 more source

SARS-CoV-2 mortality in blacks and temperature-sensitivity to an angiotensin-2 receptor blocker [PDF]

arXiv, 2020
Tropical climates provoke adaptations in skin pigmentation and in mechanisms controlling the volume, salt-content and pressure of body fluids. For many whose distant ancestors moved to temperate climes, these adaptations proved harmful: pigmentation decreased by natural selection and susceptibility to hypertension emerged.
arxiv  

Self‐Healing Hydrogel Dressing with Solubilized Flavonoids for Whole Layer Regeneration of Diabetic Wound

Advanced Healthcare Materials, EarlyView.
High glucose‐ and acid‐responsive hydrogel with dynamic covalent bond solubilized with flavonoids (Gel‐Flavonoids) is designed for diabetic wound healing. The Gel‐Flavonoids adapt to irregular wound shapes and release antioxidants in high‐glucose environments, effectively reducing reactive oxygen species.
Qiang Zeng, Sa Du, Rui Yuan, Yuan Zeng, Xuefen Li, Yu‐Wei Wu, Ke Chen, Lei Tao, Zhihui Tang, Xuliang Deng   +9 more
wiley   +1 more source

Antibodies to probe endogenous G protein-coupled receptor heteromer expression, regulation and function.

Frontiers in Pharmacology, 2014
Over the last decade an increasing number of studies have focused on the ability of G protein-coupled receptors to form heteromers and explored how receptor heteromerization modulates the binding, signaling and trafficking properties of individual ...
Ivone eGomes, Achla eGupta, Ittai eBushlin, Lakshmi A. Devi   +3 more
doaj   +1 more source

Functional Polymer Nanocomposites by Gas Aggregation Cluster Source and Initiated Chemical Vapor Deposition

Advanced Materials Technologies, EarlyView.
In this work, a gas aggregation cluster source and an initiated chemical vapor deposition are combined in a single vacuum reactor. With this setup polymer thin films can be combined with functional nanoparticles. As a proof‐of‐concept PTFE is combined with silver nanoparticles and tested in antibacterial, antiviral, and anticancer applications ...
Torge Hartig, Joschka Paulsen, Jonas Drewes, Asmaa T. Mohamed, Nasra F. Abdel Fattah, Cedric Hinrichs, Felix Pohl, Stefan Rehders, Ainura Aliyeva, Henning Wieker, Jörg Wiltfang, Salih Veziroglu, Samah A Loutfy, Oral Cenk Aktas, Alexander Vahl, Thomas Strunskus, Aydin Gülses, Amal Amin, Stefan Schröder, Franz Faupel   +19 more
wiley   +1 more source

Advancing the Identification of Bioactive Molecules and the Construction of a Synergistic Drug Delivery System in Combating Lung Injury

Advanced Science, EarlyView.
Traditional Chinese Medicine (TCM), while holistic and historically esteemed, faces challenges in “miracle cures” due to slow onset, long cycles, and difficulty controlling quality. This study obtains the active ingredients, glabridin (GLA) and puerarin (PUE), from Ge‐Gen Decoction (GGD), developing a safe and effective drug delivery system, GLA‐PUE ...
Jianhong Qi, Yanxia Wang, Huan Chen, Kaitian Wu, Pei Zhou, Yue Dou, Bingqi Xiong, Wei Zhou   +7 more
wiley   +1 more source

CD4+ Regulatory T Lymphocytes Prevent Impaired Cerebral Blood Flow in Angiotensin II‐Induced Hypertension

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background Immune cells are key regulators of the vascular inflammatory response characteristic of hypertension. In hypertensive rodents, regulatory T lymphocytes (Treg, CD4+CD25+) prevented vascular injury, cardiac damage, and endothelial dysfunction of
M. Florencia Iulita, Sonia Duchemin, Diane Vallerand, Tlili Barhoumi, Fernando Alvarez, Roman Istomine, Cyril Laurent, Jessica Youwakim, Pierre Paradis, Nathalie Arbour, Ciriaco A. Piccirillo, Ernesto L. Schiffrin, Hélène Girouard   +12 more
doaj   +1 more source