Results 1 to 10 of about 4,889,938 (291)

Pathological Role of Angiotensin II in Severe COVID-19

TH Open, 2020
The activated renin–angiotensin system induces a prothrombotic state resulting from the imbalance between coagulation and fibrinolysis. Angiotensin II is the central effector molecule of the activated renin–angiotensin system and is degraded by the ...
Wolfgang Miesbach
doaj   +2 more sources

Angiotensin II induces cholesterol accumulation and impairs insulin secretion by regulating ABCA1 in beta cells [PDF]

Journal of Lipid Research, 2018
In pancreatic β cells, ABCA1, a 254 kDa membrane protein, affects cholesterol homeostasis and insulin secretion. Angiotensin II, as the main effector of the renin–angiotensin system, decreases glucose-stimulated insulin secretion (GSIS).
Jingya Lyu, Hitomi Imachi, Kensaku Fukunaga, Seisuke Sato, Tomohiro Ibata, Toshihiro Kobayashi, Tao Dong, Takuo Yoshimoto, Kazuko Yonezaki, Hiromi Nagata, Hisakazu Iwama, Koji Murao   +11 more
doaj   +2 more sources

Angiotensin II and Cardiovascular Disease: Balancing Pathogenic and Protective Pathways [PDF]

Current Issues in Molecular Biology
The renin-angiotensin-aldosterone system (RAAS) is a hormone system that controls blood pressure and fluid and electrolyte balance. Angiotensin II, a key effector, is produced from angiotensin I by angiotensin-converting enzyme (ACE) and exerts its ...
Ulvi Bayraktutan
doaj   +2 more sources

Upregulation of NADH/NADPH oxidase 4 by angiotensin II induces podocyte apoptosis [PDF]

Kidney Research and Clinical Practice, 2023
Background Angiotensin II induces glomerular and podocyte injury via systemic and local vasoconstrictive or non-hemodynamic effects including oxidative stress. The release of reactive oxygen species (ROS) from podocytes may participate in the development
Tae-Sun Ha, Su-Bin Seong, Dong-Soo Ha, Seung Jung Kim   +3 more
doaj   +1 more source

Angiotensin converting enzyme 2 (ACE2) - the major receptor for SARS-CoV-2 virus [PDF]

Farmacja Polska, 2021
The renin-angiotensin-aldosterone system (RAS) plays a significant role in the regulation of the water and electrolyte balance. Renin from the kidneys converts angiotensinogen to angiotensin I. Angiotensin converting enzyme (ACE) catalyzes the conversion
Sonia Frankowska, Karolina Zając, Klaudia Zargaryan, Jolanta Barbara Zawilska   +3 more
doaj   +1 more source

Prolylcarboxypeptidase Alleviates Hypertensive Cardiac Remodeling by Regulating Myocardial Tissue Angiotensin II

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023
Background Prolonged activation of angiotensin II is the main mediator that contributes to the development of heart diseases, so converting angiotensin II into angiotensin 1‐7 has emerged as a new strategy to attenuate detrimental effects of angiotensin ...
Binh Y. Nguyen, Fangchao Zhou, Pablo Binder, Wei Liu, Susanne S. Hille, Xiaojing Luo, Min Zi, Hongyuan Zhang, Antony Adamson, Fozia Z. Ahmed, Sam Butterworth, Elizabeth J. Cartwright, Oliver J. Müller, Kaomei Guan, Elizabeth M. Fitzgerald, Xin Wang   +15 more
doaj   +1 more source

Association of Inpatient Use of Angiotensin-Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers With Mortality Among Patients With Hypertension Hospitalized With COVID-19

Circulation Research, 2020
Supplemental Digital Content is available in the text. Rationale: Use of ACEIs (angiotensin-converting enzyme inhibitors) and ARBs (angiotensin II receptor blockers) is a major concern for clinicians treating coronavirus disease 2019 (COVID-19) in ...
Peng Zhang, Lihua Zhu, Jingjing Cai, Fang Lei, Juan-Juan Qin, Jing Xie, Ye Liu, Yan-Ci Zhao, Xuewei Huang, Lijin Lin, Meng Xia, Ming-Ming Chen, Xu Cheng, Xiao Zhang, D. Guo, Yuanyuan Peng, Yan‐Xiao Ji, J. Chen, Zhi‐Gang She, Yibin Wang, Qingbo Xu, Renfu Tan, Hai-tao Wang, Jun Lin, Pengcheng Luo, Shouzhi Fu, Hongbing Cai, P. Ye, B. Xiao, W. Mao, Liming Liu, You-qin Yan, Mingyu Liu, Manhua Chen, Xiao-Jing Zhang, Xinghuan Wang, R. Touyz, J. Xia, Bing-Hong Zhang, Xiaodong Huang, Yufeng Yuan, L. Rohit, Peter P. Liu, Hongliang Li   +43 more
semanticscholar   +1 more source

From Angiotensin II to Cyclic Peptides and Angiotensin Receptor Blockers (ARBs): Perspectives of ARBs in COVID-19 Therapy

Molecules, 2021
The octapeptide hormone angiotensin II is one of the most studied peptides with the aim of designing and synthesizing non-peptide mimetics for oral administration.
John Matsoukas, Vasso Apostolopoulos, Anthony Zulli, Graham Moore, Konstantinos Kelaidonis, Kalliopi Moschovou, Thomas Mavromoustakos   +6 more
doaj   +1 more source

Renin and Survival in Patients Given Angiotensin II for Catecholamine-Resistant Vasodilatory Shock. A Clinical Trial

American Journal of Respiratory and Critical Care Medicine, 2020
Rationale: Exogenous angiotensin II increases mean arterial pressure in patients with catecholamine-resistant vasodilatory shock (CRVS). We hypothesized that renin concentrations may identify patients most likely to benefit from such therapy. Objectives:
R. Bellomo, L. Forni, L. Busse, M. McCurdy, Kealy R. Ham, David W. Boldt, J. Hästbacka, A. Khanna, T. Albertson, J. Tumlin, Kristine Storey, Damian R. Handisides, G. Tidmarsh, L. Chawla   +13 more
semanticscholar   +1 more source

COVID‐19 and heart failure: from infection to inflammation and angiotensin II stimulation. Searching for evidence from a new disease

European Journal of Heart Failure, 2020
Patients with cardiovascular disease and, namely, heart failure are more susceptible to coronavirus disease 2019 (COVID‐19) and have a more severe clinical course once infected.
D. Tomasoni, Leonardo Italia, M. Adamo, R. Inciardi, C. Lombardi, S. Solomon, M. Metra   +6 more
semanticscholar   +1 more source