Results 21 to 30 of about 4,889,938 (291)

The hyperglycemia induced by angiotensin II in rats is mediated by AT1 receptors

Brazilian Journal of Medical and Biological Research, 1998
We have shown that the renin-angiotensin system (RAS) is involved in glucose homeostasis during acute hemorrhage. Since almost all of the physiological actions described for angiotensin II were mediated by AT1 receptors, the present experiments were ...
L.J.C. Machado, U. Marubayashi, A.M. Reis, C.C. Coimbra   +3 more
doaj   +1 more source

Structural determinants for binding to angiotensin converting enzyme 2 (ACE2) and angiotensin receptors

Frontiers in Pharmacology, 2015
Angiotensin converting enzyme 2 (ACE2) is a zinc carboxypeptidase involved in the renin angiotensin system (RAS) and inactivates the potent vasopressive peptide angiotensin II (Ang II) by removing the C-terminal phenylalanine residue to yield Ang1-7 ...
Daniel eClayton, Iresha eHanchapola, Walter Glen Thomas, Robert eWiddop, Alexander Ian Smith, Patrick ePerlmutter, Marie-Isabel eAguilar   +6 more
doaj   +1 more source

Analysis of the Vasorelaxant Action of Angiotensin II in the Isolated Rat Renal Artery

Journal of Pharmacological Sciences, 2008
Taking into consideration that mechanisms involved in the vasodilatator actions of angiotensin II have not yet been completely elucidated, the present study was undertaken in order to examine the mechanisms underlying the angiotensin II–induced ...
Leposava Grbović, Jelena Djokić, Miroslav Radenković, Srðan Pešic   +3 more
doaj   +1 more source

Homocysteine directly interacts and activates the angiotensin II type I receptor to aggravate vascular injury

Nature Communications, 2018
Hyperhomocysteinemia (HHcy) is a risk factor for various cardiovascular diseases. However, the mechanism underlying HHcy-aggravated vascular injury remains unclear.
Tuoyi Li, Bing Yu, Zhixin Liu, Jingyuan Li, M. Ma, Yingbao Wang, Mingjiang Zhu, H. Yin, Xiaofeng Wang, Yi Fu, F. Yu, Xian Wang, X. Fang, Jin-peng Sun, W. Kong   +14 more
semanticscholar   +1 more source

Angiotensin-Converting Enzyme and Hypertension: A Systemic Analysis of Various ACE Inhibitors, Their Side Effects, and Bioactive Peptides as a Putative Therapy for Hypertension

Journal of the Renin-Angiotensin-Aldosterone System, 2023
Hypertension is a major risk factor for heart attack, produce atherosclerosis (hardening of the arteries), congestive heart failure, stroke, kidney infection, blindness, end-stage renal infection, and cardiovascular diseases. Many mechanisms are involved
H. Ahmad, Huma Khan, S. Haque, Shameem Ahmad, N. Srivastava, Azhar Khan   +5 more
semanticscholar   +1 more source

Structural Basis for Selectivity and Diversity in Angiotensin II Receptors

Nature, 2017
The angiotensin II receptors AT1R and AT2R serve as key components of the renin–angiotensin–aldosterone system. AT1R has a central role in the regulation of blood pressure, but the function of AT2R is unclear and it has a variety of reported effects.
Haitao Zhang, G. Han, A. Batyuk, A. Ishchenko, K. White, N. Patel, Anastasiia V. Sadybekov, B. Zamlynny, M. Rudd, K. Hollenstein, A. Tolstikova, T. White, M. Hunter, U. Weierstall, Wei Liu, K. Babaoglu, Eric L. Moore, R. Katz, J. Shipman, M. Garcia-Calvo, Sujata Sharma, P. Sheth, S. Soisson, R. Stevens, V. Katritch, V. Cherezov   +25 more
semanticscholar   +1 more source

Maternal plasma angiotensin 1-7 concentration is related to twin pregnancy chorionicity in the third trimester of pregnancy

Frontiers in Endocrinology
IntroductionTwin gestation is related to a higher risk of hypertensive disorders in pregnancy with possible risk stratification depending on chorionicity.
Paweł Pietruski, Katarzyna Kosińska-Kaczyńska, Agnieszka Osińska, Magdalena Zgliczyńska, Kinga Żebrowska, Katarzyna Popko, Anna Stelmaszczyk-Emmel   +6 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Role of Angiotensin Receptor Type I and Type II in the Development of Common Cardiac Problems

Journal of the Practice of Cardiovascular Sciences
The renin–angiotensin system is crucial for maintaining blood pressure and fluid balance. Central to this system are the angiotensin receptors, type I (AT1R) and type II (AT2R), which mediate the effects of angiotensin II (Ang-II).
Tannistha Hota, Mainak Sengupta, Arunachal Chatterjee   +2 more
doaj   +1 more source

Biophysical analysis of angiotensin II and amyloid‐β cross‐interaction in aggregation and membrane disruption

FEBS Letters, EarlyView.
Angiotensin II (AngII), a neuropeptide, interacts with amyloid‐β (Aβ), a key player in Alzheimer's disease. This study reveals that AngII reduces Aβ aggregation and membrane disruption in vitro. Biophysical assays and molecular modeling suggest AngII binds disordered Aβ forms, potentially modulating early amyloidogenic events and contributing to ...
Mohsen Habibnia, Eric Catalina‐Hernandez, Maialen Cabrerizo‐Idiazabal, Ramon Barnadas‐Rodríguez, Mario Lopez‐Martin, Alex Peralvarez‐Marin   +5 more
wiley   +1 more source