Results 21 to 30 of about 262,681 (286)

Comprehensive genetic screening for vascular Ehlers–Danlos syndrome through an amplification‐based next‐generation sequencing system

American Journal of Medical Genetics Part A, Volume 191, Issue 1, Page 37-51, January 2023., 2023
Abstract Vascular Ehlers–Danlos syndrome (vEDS) is a hereditary connective tissue disorder (HCTD) characterized by arterial dissection/aneurysm/rupture, sigmoid colon rupture, or uterine rupture. Diagnosis is confirmed by detecting heterozygous variants in COL3A1.
Tomomi Yamaguchi, Shujiro Hayashi, Daisuke Hayashi, Takeshi Matsuyama, Norimichi Koitabashi, Kenichi Ogiwara, Masaaki Noda, Chiai Nakada, Shinya Fujiki, Akira Furutachi, Yasuhiko Tanabe, Michiko Yamanaka, Aki Ishikawa, Miyako Mizukami, Asako Mizuguchi, Kazumitsu Sugiura, Makoto Sumi, Hirokuni Yamazawa, Atsushi Izawa, Yuko Wada, Tomomi Fujikawa, Yuri Takiguchi, Keiko Wakui, Kyoko Takano, Shin‐Ya Nishio, Tomoki Kosho   +25 more
wiley   +1 more source

Detrimental Effects of Centrally Administered Angiotensin II are Enhanced in a Mouse Model of Alzheimer Disease Independently of Blood Pressure

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
BackgroundThe significance of brain angiotensin II in Alzheimer disease (AD) is unclear. Methods and ResultsTo examine the role of brain angiotensin II in AD, intracerebroventricular angiotensin II infusion was performed on 5XFAD mice, a mouse model of ...
Koki Takane, Yu Hasegawa, Bowen Lin, Nobutaka Koibuchi, Cheng Cao, Takashi Yokoo, Shokei Kim‐Mitsuyama   +6 more
doaj   +1 more source

Angiotensin II and Renal Fibrosis [PDF]

Hypertension, 2001
Abstract — — Angiotensin (Ang) II, the main peptide of the renin angiotensin system (RAS), is a renal growth factor, inducing hyperplasia/hypertrophy depending on the cell type. This vasoactive peptide activates mesangial and tubular cells and interstitial fibroblasts, increasing the ...
Mezzano, SA, Ruiz-Ortega, M, Egido, J
openaire   +5 more sources

Regulatory effect of gut microbes on blood pressure

Animal Models and Experimental Medicine, Volume 5, Issue 6, Page 513-531, December 2022., 2022
The interaction between gut microbiota and hypertension, the genera which affect the blood pressure in taxonomic level, and the commonly used treatments to hypertension based on the gut microbes were summarized in this review. The increases of Lactobacillus, etc.
Dong Yan, Ye Sun, Xiaoyue Zhou, Wenhao Si, Jieyu Liu, Min Li, Minna Wu   +6 more
wiley   +1 more source

Label-free cell signaling pathway deconvolution of Angiotensin type 1 receptor reveals time-resolved G-protein activity and distinct AngII and AngIII\IV responses [PDF]

Pharmacol Res, 136:108-20 (2018), 2019
Angiotensin II (AngII) type 1 receptor (AT1R) is a G protein-coupled receptor known for its role in numerous physiological processes and its implication in many vascular diseases. Its functions are mediated through G protein dependent and independent signaling pathways. AT1R has several endogenous peptidic agonists, all derived from angiotensinogen, as
arxiv   +1 more source

In-Silico evidence for two receptors based strategy of SARS-CoV-2 [PDF]

Front. Mol. Biosci., 09 June 2021, 2020
We propose a novel numerical method able to determine efficiently and effectively the relationship of complementarity between portions of proteins surfaces. This innovative and general procedure, based on the representation of the molecular iso-electron density surface in terms of 2D Zernike polynomials, allows the rapid and quantitative assessment of ...
arxiv   +1 more source

Angiotensin II Antagonists

Clinical and Experimental Hypertension, 1993
Acute blockade of the renin-angiotensin system with the parenterally active angiotensin II antagonist saralasin has been shown to effectively lower blood pressure in a large fraction of patients with essential hypertension and to improve hemodynamics in some patients with congestive heart failure.
Hans R. Brunner, Michel Burnier, Jürg Nussberger, Bernard Waeber   +3 more
openaire   +3 more sources

The hyperglycemia induced by angiotensin II in rats is mediated by AT1 receptors

Brazilian Journal of Medical and Biological Research, 1998
We have shown that the renin-angiotensin system (RAS) is involved in glucose homeostasis during acute hemorrhage. Since almost all of the physiological actions described for angiotensin II were mediated by AT1 receptors, the present experiments were ...
L.J.C. Machado, U. Marubayashi, A.M. Reis, C.C. Coimbra   +3 more
doaj   +1 more source

Tetracycline as an inhibitor to the coronavirus SARS-CoV-2 [PDF]

J Cell Biochem (2021) 1-8, 2020
The coronavirus SARS-CoV-2 remains an extant threat against public health on a global scale. Cell infection begins when the spike protein of SARS-CoV-2 binds with the cell receptor, angiotensin-converting enzyme 2 (ACE2). Here, we address the role of Tetracycline as an inhibitor for the receptor-binding domain (RBD) of the spike protein.
arxiv   +1 more source

BC‐11 is a covalent TMPRSS2 fragment inhibitor that impedes SARS‐CoV‐2 host cell entry

Archiv der Pharmazie, Volume 356, Issue 1, January 2023., 2023
Drug repurposing has the potential to accelerate the discovery of TMPRSS2 inhibitors acting as COVID‐19 antivirals. In this regard, a low throughput screening led to the identification of BC‐11 as a covalent TMPRSS2 fragment inhibitor (IC50 = 1.44 µM), displaying significant SARS‐CoV‐2 entry inhibition (EC50 = 66 µM). Abstract Host cell entry of severe
Aurélien F. A. Moumbock, Hoai T. T. Tran, Evelyn Lamy, Stefan Günther   +3 more
wiley   +1 more source