Results 31 to 40 of about 4,825,321 (354)

Angiotensin II and the Heart [PDF]

Hypertension, 2000
Abstract—The active end product of the renin-angiotensin system, angiotensin II (Ang II), through the activation of specific Ang II receptors, regulates cardiac contractility, cell coupling, and impulse propagation and is involved in cardiac remodeling, growth, and apoptosis. We review these subjects, as well as the second messengers that are involved,
Walmor C. De Mello, A. H. Jan Danser
openaire   +3 more sources

Angiotensin II and Erythropoiesis.

Experimental Biology and Medicine, 1963
Summary1. Polycythemic mice and hypophysectomized rats were used as assay animals to measure the erythropoietic stimulating activity of synthetic angiotensin II (A-S) and of angiotensin II made from a crude extract of the hog kidney (A-CE). 2. No increase in erythropoietic activity, as measured by the red blood cell incorporation of Fe59, was found ...
Wood Je, Bilsel Yc, Lange Rd
openaire   +3 more sources

Structural Basis for Selectivity and Diversity in Angiotensin II Receptors

Nature, 2017
The angiotensin II receptors AT1R and AT2R serve as key components of the renin–angiotensin–aldosterone system. AT1R has a central role in the regulation of blood pressure, but the function of AT2R is unclear and it has a variety of reported effects.
Haitao Zhang, G. Han, A. Batyuk, A. Ishchenko, K. White, N. Patel, Anastasiia V. Sadybekov, B. Zamlynny, M. Rudd, K. Hollenstein, A. Tolstikova, T. White, M. Hunter, U. Weierstall, Wei Liu, K. Babaoglu, Eric L. Moore, R. Katz, J. Shipman, M. Garcia-Calvo, Sujata Sharma, P. Sheth, S. Soisson, R. Stevens, V. Katritch, V. Cherezov   +25 more
semanticscholar   +1 more source

Angiotensin II-mediated hypertension in the rat increases vascular superoxide production via membrane NADH/NADPH oxidase activation. Contribution to alterations of vasomotor tone.

Journal of Clinical Investigation, 1996
We tested the hypothesis that angiotensin II-induced hypertension is associated with an increase in vascular .O2- production, and characterized the oxidase involved in this process.
S. Rajagopalan, Sabine Kurz, T. Münzel, M. Tarpey, B. Freeman, K. Griendling, D. Harrison   +6 more
semanticscholar   +1 more source

Angiotensin II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells.

Circulation Research, 1994
The signaling pathways involved in the long-term metabolic effects of angiotensin II (Ang II) in vascular smooth muscle cells are incompletely understood but include the generation of molecules likely to affect oxidase activity.
K. Griendling, C. Minieri, J D Ollerenshaw, R. Alexander   +3 more
semanticscholar   +1 more source

Current trends in single‐cell RNA sequencing applications in diabetes mellitus

FEBS Open Bio, EarlyView.
Single‐cell RNA sequencing is a powerful approach to decipher the cellular and molecular landscape at a single‐cell resolution. The rapid development of this technology has led to a wide range of applications, including the detection of cellular and molecular mechanisms and the identification and introduction of novel potential diagnostic and ...
Seyed Sajjad Zadian, Khodakaram Jahanbin, Shekoofeh Nikooei, Marzieh Rostaminejad, Arezoo Rahimi, Pedram Abdizadeh, Behnam Alipoor   +6 more
wiley   +1 more source

Maternal plasma angiotensin 1-7 concentration is related to twin pregnancy chorionicity in the third trimester of pregnancy

Frontiers in Endocrinology
IntroductionTwin gestation is related to a higher risk of hypertensive disorders in pregnancy with possible risk stratification depending on chorionicity.
Paweł Pietruski, Katarzyna Kosińska-Kaczyńska, Agnieszka Osińska, Magdalena Zgliczyńska, Kinga Żebrowska, Katarzyna Popko, Anna Stelmaszczyk-Emmel   +6 more
doaj   +1 more source

Role of angiotensin II in aging

Frontiers in Aging Neuroscience, 2022
Aging is an inevitable progressive decline in physiological organ function that increases the chance of disease and death. The renin–angiotensin system (RAS) is involved in the regulation of vasoconstriction, fluid homeostasis, cell growth, fibrosis, inflammation, and oxidative stress. In recent years, unprecedented advancement has been made in the RAS
Wenmin Yi, Wenmin Yi, Wenmin Yi, Wenmin Yi, Wenmin Yi, Fei Chen, Fei Chen, Fei Chen, Fei Chen, Fei Chen, Huiji Zhang, Huiji Zhang, Huiji Zhang, Huiji Zhang, Peng Tang, Peng Tang, Minghao Yuan, Minghao Yuan, Minghao Yuan, Minghao Yuan, Minghao Yuan, Jie Wen, Jie Wen, Shengyuan Wang, Shengyuan Wang, Shengyuan Wang, Shengyuan Wang, Shengyuan Wang, Zhiyou Cai, Zhiyou Cai, Zhiyou Cai, Zhiyou Cai, Zhiyou Cai   +32 more
openaire   +3 more sources

SARS‐CoV‐2 Is Linked to Brain Volume Loss in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The impact of SARS‐CoV‐2 infection on brain and spinal cord pathology in patients with multiple sclerosis (pwMS) remains unclear. We aimed to describe changes in brain lesion activity and brain and spinal cord volumes following SARS‐CoV‐2 infection.
Tomas Uher, Dominika Stastna, Ingrid Menkyova, Vaclav Capek, Jiri Lindner, Petra Nytrova, Jan Krasensky, Eliza Varju, Miguel D'haeseleer, Eva Kubala Havrdova, Dana Horakova, Manuela Vaneckova, Niels Bergsland   +12 more
wiley   +1 more source

Metabolic Consequences of Rheumatoid Arthritis

Arthritis Care &Research, EarlyView.
Patients with rheumatoid arthritis (RA) may have metabolic disruption, which can contribute to adverse long‐term outcomes, for multiple reasons. Patients with RA appear to have a higher risk of sarcopenia, type 1 and type 2 diabetes mellitus, metabolic syndrome, and hypertension. Systemic inflammation in RA can cause a “lipid paradox,” with reduced low‐
Stevie Barry, Emily Sheng, Joshua F. Baker   +2 more
wiley   +1 more source