Results 31 to 40 of about 5,061,790 (379)

Angiotensin II-Real-Life Use and Literature Review. [PDF]

Medicina (Kaunas)
Angiotensin II is a recently introduced vasopressor, which has been available since 2017. The novelty and the relatively high cost of angiotensin II currently limit its broader application.
Möller Petrun A, Markota A.
europepmc   +2 more sources

Transgenic amplification of glucocorticoid action in adipose tissue causes high blood pressure in mice [PDF]

, 2003
Obesity is closely associated with the metabolic syndrome, a combination of disorders including insulin resistance, diabetes, dyslipidemia, and hypertension.
Aubert, Busetto, Butz, Christopher J. Kenyon, Contreras, Cowley, De la Sieera, Folli, Frederich, Hiroaki Masuzaki, Hiroshi Shinyama, Hiroshi Yamamoto, Janice M. Paterson, Jeffrey S. Flier, Joel K. Elmquist, John J. Mullins, Johnson, Jonathan R. Seckl, Kopelman, Lalouel, Llorens-Cortes, Massiera, Masuzaki, Matthew G.F. Sharp, Miller, Mills, Montani, Morton, Nicholas M. Morton, O’Brien, Pradevand, Pratt, Rotimi, Stepp, Stewart Fleming, Villiquette, Walker, Weinburger, Williams, Yamamoto   +39 more
core   +5 more sources

Advance in Research of Angiotensin II and Its Receptor and Malignant Tumor

Chinese Journal of Lung Cancer, 2016
Angiotensin AngII, a linear small peptide,which is composed of eight amino acids, is the main effectors of renin-angiotensin systen (Renin-angiotensin system, RAS).
Lulu SUN, Jian SHI
doaj   +1 more source

Angiotensin II cyclic analogs as tools to investigate AT1R biased signaling mechanisms [PDF]

St-Pierre D, et al. (2018), Biochem Pharmacol. 154:104-17, 2019
G protein coupled receptors (GPCRs) produce pleiotropic effects by their capacity to engage numerous signaling pathways once activated. Functional selectivity (also called biased signaling), where specific compounds can bring GPCRs to adopt conformations that enable selective receptor coupling to distinct signaling pathways, continues to be ...
arxiv   +1 more source

Atypical angiotensin II receptors coupled to phosphoinositide turnover/calcium signalling in catfish hepatocytes [PDF]

, 1997
In catfish (Ictalurus punctatus) hepatocytes angiotensin II induced an immediate increase in cytosolic Ca2+ concentration. Other angiotensin analogues also induced this effect including: human angiotensin II, fish angiotensin II, human angiotensin III ...
Garcı́a-Sáinz, J.Adolfo, Macı́as-Silva, Marina, Olivares-Reyes, J.Alberto   +2 more
core   +1 more source

Detrimental Effects of Centrally Administered Angiotensin II are Enhanced in a Mouse Model of Alzheimer Disease Independently of Blood Pressure

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
BackgroundThe significance of brain angiotensin II in Alzheimer disease (AD) is unclear. Methods and ResultsTo examine the role of brain angiotensin II in AD, intracerebroventricular angiotensin II infusion was performed on 5XFAD mice, a mouse model of ...
Koki Takane, Yu Hasegawa, Bowen Lin, Nobutaka Koibuchi, Cheng Cao, Takashi Yokoo, Shokei Kim‐Mitsuyama   +6 more
doaj   +1 more source

Conversion and degradation of [125I] labelled angiotensin I in isolated perfused porcine coronary and carotid arteries [PDF]

, 1994
The aims were (1) to quantitate angiotensin I to II conversion on the endothelial surface and at deeper sites in isolated arteries, (2) to assess whether the angiotensin II that is formed at deeper sites is released into the vascular lumen, and (3) to ...
Chowdury, S. (Suchandana), Danser, A.H.J. (Jan), Giessen, W.J. (Wim) van der, Lannoy, L.M. (Larissa) de, Saxena, P.R. (Pramod Ranjan), Schalekamp, M.A.D.H. (Maarten)   +5 more
core   +1 more source

Ang II (Angiotensin II) Conversion to Angiotensin-(1-7) in the Circulation Is POP (Prolyloligopeptidase)-Dependent and ACE2 (Angiotensin-Converting Enzyme 2)-Independent.

HYPERTENSION, 2019
The Ang II (Angiotensin II)-Angiotensin-(1-7) axis of the Renin Angiotensin System encompasses 3 enzymes that form Angiotensin-(1-7) [Ang-(1-7)] directly from Ang II: ACE2 (angiotensin-converting enzyme 2), PRCP (prolylcarboxypeptidase), and POP ...
P. Serfozo, J. Wysocki, Gvantca Gulua, Arndt Schulze, M. Ye, Pan Liu, Jing Jin, M. Bader, M. Bader, T. Myöhänen, J. Garcia-horsman, D. Batlle   +11 more
semanticscholar   +1 more source

Label-free cell signaling pathway deconvolution of Angiotensin type 1 receptor reveals time-resolved G-protein activity and distinct AngII and AngIII\IV responses [PDF]

Pharmacol Res, 136:108-20 (2018), 2019
Angiotensin II (AngII) type 1 receptor (AT1R) is a G protein-coupled receptor known for its role in numerous physiological processes and its implication in many vascular diseases. Its functions are mediated through G protein dependent and independent signaling pathways. AT1R has several endogenous peptidic agonists, all derived from angiotensinogen, as
arxiv   +1 more source

Tetracycline as an inhibitor to the coronavirus SARS-CoV-2 [PDF]

J Cell Biochem (2021) 1-8, 2020
The coronavirus SARS-CoV-2 remains an extant threat against public health on a global scale. Cell infection begins when the spike protein of SARS-CoV-2 binds with the cell receptor, angiotensin-converting enzyme 2 (ACE2). Here, we address the role of Tetracycline as an inhibitor for the receptor-binding domain (RBD) of the spike protein.
arxiv   +1 more source