Results 31 to 40 of about 4,861,792 (337)
Nature Communications, 2018 Hyperhomocysteinemia (HHcy) is a risk factor for various cardiovascular diseases. However, the mechanism underlying HHcy-aggravated vascular injury remains unclear.
Tuoyi Li +14 more
semanticscholar +1 more source
Clinical and Experimental Hypertension, 1993 Acute blockade of the renin-angiotensin system with the parenterally active angiotensin II antagonist saralasin has been shown to effectively lower blood pressure in a large fraction of patients with essential hypertension and to improve hemodynamics in some patients with congestive heart failure.
Hans R. Brunner +3 more
openaire +3 more sources
Angiotensin II and the Heart [PDF]
Hypertension, 2000 Abstract—The active end product of the renin-angiotensin system, angiotensin II (Ang II), through the activation of specific Ang II receptors, regulates cardiac contractility, cell coupling, and impulse propagation and is involved in cardiac remodeling, growth, and apoptosis. We review these subjects, as well as the second messengers that are involved,
Walmor C. De Mello, A. H. Jan Danser
openaire +3 more sources
Angiotensin II and Erythropoiesis.
Experimental Biology and Medicine, 1963 Summary1. Polycythemic mice and hypophysectomized rats were used as assay animals to measure the erythropoietic stimulating activity of synthetic angiotensin II (A-S) and of angiotensin II made from a crude extract of the hog kidney (A-CE). 2. No increase in erythropoietic activity, as measured by the red blood cell incorporation of Fe59, was found ...
Wood Je, Bilsel Yc, Lange Rd
openaire +3 more sources
Journal of the Renin-Angiotensin-Aldosterone System, 2023 Hypertension is a major risk factor for heart attack, produce atherosclerosis (hardening of the arteries), congestive heart failure, stroke, kidney infection, blindness, end-stage renal infection, and cardiovascular diseases. Many mechanisms are involved
H. Ahmad +5 more
semanticscholar +1 more source
Structural Basis for Selectivity and Diversity in Angiotensin II Receptors
Nature, 2017 The angiotensin II receptors AT1R and AT2R serve as key components of the renin–angiotensin–aldosterone system. AT1R has a central role in the regulation of blood pressure, but the function of AT2R is unclear and it has a variety of reported effects.
Haitao Zhang +25 more
semanticscholar +1 more source
Frontiers in EndocrinologyIntroductionTwin gestation is related to a higher risk of hypertensive disorders in pregnancy with possible risk stratification depending on chorionicity.
Paweł Pietruski +6 more
doaj +1 more source
Current trends in single‐cell RNA sequencing applications in diabetes mellitus
FEBS Open Bio, EarlyView.Single‐cell RNA sequencing is a powerful approach to decipher the cellular and molecular landscape at a single‐cell resolution. The rapid development of this technology has led to a wide range of applications, including the detection of cellular and molecular mechanisms and the identification and introduction of novel potential diagnostic and ...
Seyed Sajjad Zadian +6 more
wiley +1 more source
Journal of Pharmacological Sciences, 2010 Chymase plays a crucial role in angiotensin II formation in various tissues. Angiotensin II induces gene expression of transforming growth factor (TGF)-β and matrix metalloproteinase (MMP)-9 precursors, and chymase can convert precursors of TGF-β and MMP-
Shinji Takai, Denan Jin, Mizuo Miyazaki
doaj +1 more source
On the Origin of Urinary Angiotensin II [PDF]
Hypertension, 2010 To the Editor: With great interest we read the publication by Shao et al,1 who propose that angiotensin (Ang) II type 1 (AT1) receptor stimulation in the kidney results in urinary Ang II excretion. The authors have used an elegant approach, infusing rats with Val5-Ang II to allow a clear distinction from endogenous Ile5-Ang II, here denoted as Ang II.
Mieke van den Heuvel +2 more
openaire +4 more sources