Results 1 to 10 of about 11,372 (280)

In Vitro Killing Activities of Anidulafungin and Micafungin with and without Nikkomycin Z against Four Candida auris Clades [PDF]

Pharmaceutics, 2023
Candida auris is a multidrug-resistant pathogen against which echinocandins are the drug of choice. However, information on how the chitin synthase inhibitor nikkomycin Z influences the killing activities of echinocandins against C.
Awid Adnan, Andrew M. Borman, Zoltán Tóth, Lajos Forgács, Renátó Kovács, Dávid Balázsi, Bence Balázs, Gergely Udvarhelyi, Gábor Kardos, László Majoros   +9 more
doaj   +3 more sources

Anidulafungin in the treatment of invasive fungal infections

Therapeutics and Clinical Risk Management, 2008
Kathryn Sabol, Tawanda GumboUniversity of Texas Southwestern Medical Center, Dallas, TX, USAAbstract: More antifungal agents have reached clinical use in the past two decades than at any other time.
Kathryn Sabol, Tawanda Gumbo
doaj   +5 more sources

In Vitro Activitiy of Rezafungin in Comparison with Anidulafungin and Caspofungin against Invasive Fungal Isolates (2017 to 2022) in China [PDF]

Journal of Fungi
The efficacy of different echinocandins is assessed by evaluating the in vitro activity of a novel antifungal, rezafungin, against invasive fungal isolates in comparison with anidulafungin and caspofungin.
Simin Yang, Feifei Wan, Min Zhang, Huiping Lin, Liang Hu, Ziyi Zhou, Dongjiang Wang, Aiping Zhou, Lijun Ni, Jian Guo, Wenjuan Wu   +10 more
doaj   +3 more sources

Anti-Fungal Drug Anidulafungin Inhibits SARS-CoV-2 Spike-Induced Syncytia Formation by Targeting ACE2-Spike Protein Interaction

Frontiers in Genetics, 2022
Drug repositioning continues to be the most effective, practicable possibility to treat COVID-19 patients. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus enters target cells by binding to the ACE2 receptor via its spike (S ...
Shahzaib Ahamad, Hashim Ali, Hashim Ali, Ilaria Secco, Mauro Giacca, Mauro Giacca, Mauro Giacca, Dinesh Gupta   +7 more
doaj   +2 more sources

Evaluation of the in vitro Activity and in vivo Efficacy of Anidulafungin-Loaded Human Serum Albumin Nanoparticles Against Candida albicans

Frontiers in Microbiology, 2021
Recent decades have seen a significant increase in invasive fungal infections, resulting in unacceptably high mortality rates. Anidulafungin (AN) is the newest echinocandin and appears to have several advantages over existing antifungals.
Yu Zhang, Yan-Chao Liu, Yan-Chao Liu, Si-Min Chen, Hui Zong, Wei-Tong Hou, Xi-Ran Qiu, Shi-Yu Guo, Yu-Fang Sun, Yuan-Ying Jiang, Mao-Mao An, Hui Shen   +11 more
doaj   +2 more sources

Repurposing Anidulafungin for Alzheimer's Disease via Fragment-Based Drug Discovery. [PDF]

ACS Chem Neurosci
The misfolding and aggregation of beta-amyloid (Aβ) peptides have been implicated as key pathogenic events in the early stages of Alzheimer’s disease (AD).
Xie S, Liang Y, Song Y, Li T, Jia J.
europepmc   +2 more sources

In Vitro Interaction and Killing-Kinetics of Amphotericin B Combined with Anidulafungin or Caspofungin against Candida auris

Pharmaceutics, 2021
Treatment of invasive infections caused by Candida auris is challenging due to the limited therapeutic options. The combination of antifungal drugs may be an interesting and feasible approach to be investigated.
Unai Caballero, Elena Eraso, Guillermo Quindós, Nerea Jauregizar   +3 more
doaj   +2 more sources

Comparison of In Vitro Killing Activity of Rezafungin, Anidulafungin, Caspofungin, and Micafungin against Four Candida auris Clades in RPMI-1640 in the Absence and Presence of Human Serum

Microorganisms, 2021
Candida auris is an emerging and frequently multidrug-resistant pathogen against which the echinocandins are the preferred therapeutic option. We compared killing activities of anidulafungin, caspofungin, micafungin, and rezafungin against 13 isolates ...
Renátó Kovács, Zoltán Tóth, Jeffrey B. Locke, Lajos Forgács, Gábor Kardos, Fruzsina Nagy, Andrew M. Borman, László Majoros   +7 more
doaj   +2 more sources

In Vitro and In Vivo Activity of Citral in Combination with Amphotericin B, Anidulafungin and Fluconazole against Candida auris Isolates

Journal of Fungi, 2023
Candida auris is an emerging fungal pathogen responsible for hospital outbreaks of invasive candidiasis associated with high mortality. The treatment of these mycoses is a clinical challenge due to the high resistance levels of this species to current ...
Iñigo de-la-Fuente, Andrea Guridi, Nerea Jauregizar, Elena Eraso, Guillermo Quindós, Elena Sevillano   +5 more
doaj   +2 more sources

Anidulafungin Treatment Blocks the Sexual Cycle of Pneumocystis murina and Prevents Growth and Survival without Rescue by an Alternative Mode of Replication

Microbiology Spectrum, 2022
The proposed life cycle of fungi in the genus Pneumocystis has typically included both an asexual cycle via binary fission and a sexual cycle. Until recently, the strategy used for sexual replication was largely unknown, but genomic and functional assays
Melanie T. Cushion, Alan Ashbaugh, Steven G. Sayson, Christopher Mosley, Philippe M. Hauser   +4 more
doaj   +2 more sources