Results 21 to 30 of about 10,059 (251)

Pan-Echinocandin Resistant C. parapsilosis Harboring an F652S Fks1 Alteration in a Patient with Prolonged Echinocandin Therapy

Journal of Fungi, 2022
The isolation of a pan-echinocandin-resistant Candida parapsilosis strain (anidulafungin, caspofungin, micafungin and rezafungin EUCAST MICs > 8 mg/L) from urine of a patient following prolonged exposure to echinocandins (38 days of micafungin followed ...
Maria Siopi, Antonios Papadopoulos, Anastasia Spiliopoulou, Fotini Paliogianni, Nissrine Abou-Chakra, Maiken Cavling Arendrup, Christina Damoulari, Georgios Tsioulos, Efthymia Giannitsioti, Frantzeska Frantzeskaki, Iraklis Tsangaris, Spyros Pournaras, Joseph Meletiadis   +12 more
doaj   +1 more source

Does Weight Impact Anidulafungin Pharmacokinetics? [PDF]

Clinical Pharmacokinetics, 2016
Bodyweight has been shown to influence anidulafungin exposure, but data from obese patients are lacking. We determined anidulafungin pharmacokinetics (100-mg single dose) in eight morbidly obese subjects (body mass index >40 kg/m(2)). Anidulafungin exposure was on average 32.5 % lower compared with the general patient population, suggesting dose ...
Lempers, V.J., Rongen, A. van, Dongen, E.P. van, Ramshorst, B. van, Burger, D.M., Aarnoutse, R.E., Knibbe, C.A.J., Bruggemann, R.J.   +7 more
openaire   +6 more sources

Safety and Pharmacokinetics of Intravenous Anidulafungin in Children with Neutropenia at High Risk for Invasive Fungal Infections

Antimicrobial Agents and Chemotherapy, 2006
Daniel K. Benjamin, Timothy Driscoll, Nita L. Seibel, Corina E. Gonzalez, Maureen Roden, Rahki Kilaru, Kay Clark, James A. Dowell, Jennifer Schranz, Thomas J. Walsh   +9 more
exaly   +2 more sources

Evaluation of the in vitro Activity and in vivo Efficacy of Anidulafungin-Loaded Human Serum Albumin Nanoparticles Against Candida albicans

Frontiers in Microbiology, 2021
Recent decades have seen a significant increase in invasive fungal infections, resulting in unacceptably high mortality rates. Anidulafungin (AN) is the newest echinocandin and appears to have several advantages over existing antifungals.
Yu Zhang, Yan-Chao Liu, Yan-Chao Liu, Si-Min Chen, Hui Zong, Wei-Tong Hou, Xi-Ran Qiu, Shi-Yu Guo, Yu-Fang Sun, Yuan-Ying Jiang, Mao-Mao An, Hui Shen   +11 more
doaj   +1 more source

In vitro anidulafungin activity against yeasts – system and disseminated mycosis pathogens

Онкогематология, 2015
We analyzed susceptibility to anidulafungin of yeasts clinical strains of Candida (14 species), Cryptococcus (1 species), Geotrichum (1 species), Rhodotorula (1 species) and Saccharomyces (1 species).
A. B. Kulko
doaj   +1 more source

Candidemia in cancer patients: phenotypical and molecular-genetic characteristics of antifungal drug resistance, pathogenic factor genes of Candida spp.

Сибирский онкологический журнал, 2022
Relevance. The global trend of rapid increase in resistance to antifungal drugs due to multiple factors, dictates the need for continuous monitoring of taxonomic structure and susceptibility of nosocomial pathogens, causing invasive fungal infections ...
N. S. Bagirova, E. A. Goremykina, P. V. Slukin, O. E. Khokhlova, N. K. Fursova, I. N. Petukhova, Z. V. Grigorievskaya   +6 more
doaj   +1 more source

Caspofungin Treatment of Aspergillus fumigatus Results in ChsG-Dependent Upregulation of Chitin Synthesis and the Formation of Chitin-Rich Microcolonies [PDF]

, 2015
Date of Acceptance: 23/07/2015 We thank Gillian Milne for help with electron microscopy, Sophie M. Schäfer for pilot experiments, and Emilia Mellado for strains. All authors acknowledge financial support of Gilead Sciences through Ph.D.
Gow, Neil A R, Lee, Keunsook, Munro, Carol A, Walker, Louise A   +3 more
core   +1 more source

Retrospective cohort study comparing the risk of severe hepatotoxicity in hospitalized patients treated with echinocandins for invasive candidiasis in the presence of confounding by indication

BMC Infectious Diseases, 2018
Background To compare the risk of severe hepatotoxicity with anidulafungin versus caspofungin and micafungin in hospitalized adults. Methods This retrospective cohort study combined data from two large US- based hospital electronic medical record ...
Francis Vekeman, Lisa Weiss, Jalal Aram, Raluca Ionescu-Ittu, Shahrzad Moosavi, Yongling Xiao, Wendy Y. Cheng, Rachel H. Bhak, Margaret Tawadrous, M. Rita Capparella, Philippe Montravers, Mei Sheng Duh   +11 more
doaj   +1 more source

SRSF5‐Mediated Alternative Splicing of M Gene is Essential for Influenza A Virus Replication: A Host‐Directed Target Against Influenza Virus

Advanced Science, 2022
Splicing of influenza A virus (IAV) RNA is an essential process in the viral life cycle that involves the co‐opting of host factors. Here, it is demonstrated that induction of host serine and arginine‐rich splicing factor 5 (SRSF5) by IAV facilitated ...
Qiuchen Li, Zhimin Jiang, Shuning Ren, Hui Guo, Zhimin Song, Saini Chen, Xintao Gao, Fanfeng Meng, Junda Zhu, Litao Liu, Qi Tong, Honglei Sun, Yipeng Sun, Juan Pu, Kin‐Chow Chang, Jinhua Liu   +15 more
doaj   +1 more source

Invasive candidiasis in children

Журнал инфектологии, 2021
The prevalence of invasive candidiasis (IC) in pediatric hospitals is from 4,3 to 15,2 per 10,000 hospitalized, in ICU – from 3,5 to 7 cases per 1,000, with HSCT – 2,9%. The average length of stay of a patient in the hospital before the development of IC
N. N. Klimko, O. P. Kozlova
doaj   +1 more source