Results 21 to 30 of about 12,047 (282)

FKS1 mutation associated with decreased echinocandin susceptibility of Aspergillus fumigatus following anidulafungin exposure [PDF]

Scientific Reports, 2020
Invasive aspergillosis (IA) is a potentially lethal infection that affects mostly immunocompromised patients caused by Aspergillus fumigatus. Echinocandins are a second-line therapy against IA, used as a salvage therapy as well as for empirical or ...
Ana P. Silva, Isabel M. Miranda, Joana Branco, Patrícia Oliveira, Isabel Faria‐Ramos, Raquel M. Silva, Acácio G. Rodrigues, Sofia Costa‐de‐Oliveira   +7 more
openalex   +2 more sources

Anidulafungin liposome nanoparticles exhibit antifungal activity against planktonic and biofilm Candida albicans

Journal of Biomedical Materials Research. Part A, 2020
Fungal infections can cause significant patient morbidity and mortality. Nanoparticle therapeutics have the potential to improve treatment of these infections.
Noel Vera‐González, Christina M. Bailey‐Hytholt, Luc Langlois, Felipe de Camargo Ribeiro, Evelyn Luzia de Souza Santos, Juliana Campos Junqueira, Anita Shukla   +6 more
openalex   +3 more sources

Optimizing anidulafungin exposure across a wide adult body size range

Antimicrobial Agents and Chemotherapy, 2023
Echinocandins like anidulafungin are first-line therapies for candidemia and invasive candidiasis, but their dosing may be suboptimal in obese patients.
Ronald G. Hall, Shuhan Liu, William C Putnam, Rajareddy Kallem, T. Gumbo, M. Pai   +5 more
semanticscholar   +1 more source

Minimum Inhibitory Concentrations of Anidulafungin as a Potential Predictor of Biocide Susceptibility of Clade 1 Candidozyma (Candida) auris Isolates. [PDF]

Microbiologyopen
Our study shows that a decision tree trained on antifungal MIC profiles, especially anidulafungin, can predict how susceptible Candida auris is to triclosan, chlorine, and chlorhexidine. This shows a possible way to cut down on routine biocide testing in infection control surveillance. ABSTRACT Candidozyma (Candida) auris is a multidrug‐resistant yeast
Erganis S, Seyer A, Mustapha MT, Yuvali M, Martli F, Algin S, Turan Uzuntas S, Yavuz B, Dogan A, Kılıc E, Kirca F, Usman AG, Sahin EA, Ergin C, Dinc B, Uzun Ozsahin D, Kalkanci A.   +16 more
europepmc   +2 more sources

The Changing Epidemiology of Breakthrough Invasive Fungal Disease in Allogeneic Hematopoietic Stem Cell Transplant Recipients in the Era of Modified-Release Posaconazole Prophylaxis. [PDF]

Transpl Infect Dis
This single‐center retrospective cohort study on 300 allogeneic hematopoietic stem cell transplant recipients from January 2017 to May 2020, in which posaconazole modified release was the most common primary antifungal prophylaxis, demonstrated a breakthrough invasive fungal disease (bIFD) rate of 9%, with associated significant all‐cause mortality at ...
Tio SY, Neoh CF, Ritchie D, Chee L, Kong DCM, Worth LJ, Yong MK, Slavin MA.   +7 more
europepmc   +2 more sources

Cost-effectiveness analysis and budgetary impact of anidulafungin treatment for patients with candidemia and other forms of invasive candidiasis in Brazil

Revista do Instituto de Medicina Tropical de São Paulo, 2023
Candidemia and other forms of invasive candidiasis (C/IC) are serious conditions, especially for immunosuppressed individuals with prolonged hospitalization in intensive care units (ICU).
C. Vianna, G. B. Mosegui, M. S. Rodrigues   +2 more
semanticscholar   +1 more source

A New Antifungal-Loaded Sol-Gel Can Prevent Candida albicans Prosthetic Joint Infection

Antibiotics, 2021
Fungal PJI is one of the most feared complications after arthroplasty. Although a rare finding, its high associated morbidity and mortality makes it an important object of study. The most frequent species causing fungal PJI is C. albicans. New technology
Hugo Garlito-Díaz, Jaime Esteban, Aranzazu Mediero, Rafael Alfredo Carias-Cálix, Beatriz Toirac, Francisca Mulero, Víctor Faus-Rodrigo, Antonia Jiménez-Morales, Emilio Calvo, John Jairo Aguilera-Correa   +9 more
doaj   +1 more source

Treatment of Primary Pulmonary Aspergillosis: An Assessment of the Evidence. [PDF]

, 2016
Aspergillus spp. are a group of filamentous molds that were first described due to a perceived similarity to an aspergillum, or liturgical device used to sprinkle holy water, when viewed under a microscope.
Stewart, Ethan R, Thompson, George R
core   +8 more sources

In Vitro Susceptibilities of Worldwide Isolates of Intrapulmonary Aspergillus Species and Important Candida Species in Sterile Body Sites against Important Antifungals: Data from the Antimicrobial Testing Leadership and Surveillance Program, 2017–2020

Microbiology Spectrum, 2022
To understand the changes of resistance in clinically commonly encountered fungi, we used the Antimicrobial Testing Leadership and Surveillance (ATLAS) database to explore in vitro antifungal susceptibilities against clinically important isolates of ...
Shio-Shin Jean, Hung-Jen Yang, Po-Chuen Hsieh, Yu-Tsung Huang, Wen-Chien Ko, Po-Ren Hsueh   +5 more
doaj   +1 more source

Antiviral activity and mechanism of the antifungal drug, anidulafungin, suggesting its potential to promote treatment of viral diseases

BMC Medicine, 2022
The severe fever with thrombocytopenia syndrome disease (SFTS), caused by the novel tick-borne SFTS virus (SFTSV), was listed among the top 10 priority infectious disease by World Health Organization due to the high fatality rate of 5–30% and the lack of
S. Shěn, Yaxian Zhang, Zhiyun Yin, Qiong Zhu, Jìngyuàn Zhāng, T. Wang, Yaohui Fang, Xiaoli Wu, Yuanzhe Bai, Shiyu Dai, Xi-Juan Liu, Jiayin Jin, Shuang Tang, Jia Liu, Manli Wang, Yu Guo, Fei Deng   +16 more
semanticscholar   +1 more source