Results 41 to 50 of about 11,372 (280)

Micafungin versus anidulafungin in critically ill patients with invasive candidiasis: A retrospective study [PDF]

, 2016
_Background:_ In critically ill patients the incidence of invasive fungal infections caused by Candida spp. has increased remarkably. Echinocandins are recommended as initial treatment for invasive fungal infections. The safety and efficacy of micafungin
Geest, P.J. (Patrick) van der, Groeneveld, A.B.J. (Johan), Hunfeld, N.G.M. (Nicole), Ladage, S.E. (Sophie E.)   +3 more
core   +4 more sources

Efficacy of Voriconazole, Isavuconazole, Fluconazole, and Anidulafungin in the Treatment of Emerging Candida auris Using an Immunocompromised Murine Model of Disseminated Candidiasis

Antimicrobial Agents and Chemotherapy, 2021
Antifungal activity of anidulafungin, voriconazole, isavuconazole, and fluconazole in the treatment of Candida auris was determined in vitro and in vivo.
A. Gamal, L. Long, J. Herrada, J. Aram, T. McCormick, M. Ghannoum   +5 more
semanticscholar   +1 more source

Reviews Of Anti‐infective Agents: Anidulafungin: A Novel Echinocandin [PDF]

Clinical Infectious Diseases, 2006
Until recently, the treatment available for serious fungal infections was composed of amphotericin B and azoles, and each class demonstrated significant limitations. Echinocandins are a new class of drugs that have shown promising results in treating a variety of fungal infections.
Jose A. Vazquez, Jack D. Sobel
openaire   +3 more sources

Does Weight Impact Anidulafungin Pharmacokinetics? [PDF]

Clinical Pharmacokinetics, 2016
Bodyweight has been shown to influence anidulafungin exposure, but data from obese patients are lacking. We determined anidulafungin pharmacokinetics (100-mg single dose) in eight morbidly obese subjects (body mass index >40 kg/m(2)). Anidulafungin exposure was on average 32.5 % lower compared with the general patient population, suggesting dose ...
Lempers, V.J., Rongen, A. van, Dongen, E.P. van, Ramshorst, B. van, Burger, D.M., Aarnoutse, R.E., Knibbe, C.A.J., Bruggemann, R.J.   +7 more
openaire   +6 more sources

MIC distributions for amphotericin B, fluconazole, itraconazole, voriconazole, flucytosine and anidulafungin and 35 uncommon pathogenic yeast species from the UK determined using the CLSI broth microdilution method.

Journal of Antimicrobial Chemotherapy, 2020
BACKGROUND Epidemiological cut-off values and clinical interpretive breakpoints have been developed for a number of antifungal agents with the most common Candida species that account for the majority of infections due to pathogenic yeasts species ...
A. Borman, Julian Muller, Jo Walsh-Quantick, A. Székely, Zoe Patterson, M. Palmer, M. Fraser, Elizabeth M. Johnson   +7 more
semanticscholar   +1 more source

Caspofungin Treatment of Aspergillus fumigatus Results in ChsG-Dependent Upregulation of Chitin Synthesis and the Formation of Chitin-Rich Microcolonies [PDF]

, 2015
Date of Acceptance: 23/07/2015 We thank Gillian Milne for help with electron microscopy, Sophie M. Schäfer for pilot experiments, and Emilia Mellado for strains. All authors acknowledge financial support of Gilead Sciences through Ph.D.
Gow, Neil A R, Lee, Keunsook, Munro, Carol A, Walker, Louise A   +3 more
core   +1 more source

Fungal infections today: size of the problem and focus on the initial cost of therapy with echinocandin

Farmeconomia: Health Economics and Therapeutic Pathways, 2010
Three candins had been approved for the treatment of invasive candidiasis (IC): caspofungin, micafungin, and anidulafungin. Different drugs are associated with different needs for dose adjustment which might affect the total cost.
Mario Venditti
doaj   +1 more source

Assessing the Impact of Prophylactic Anidulafungin during Remission Induction of Acute Myeloid Leukemia - a Propensity-Score Matching Analysis

Blood, 2021
Introduction: Invasive fungal disease (IFD) accounts for substantial morbidity during the treatment of acute myeloid leukemia (AML) in adults. Antifungal prophylaxis (AP) is needed during intensive chemotherapy, and posaconazole has recently emerged as
W. Silva, F. Mendes, R. Melo, Elvira D R P Velloso, V. Rocha, E. Rego   +5 more
semanticscholar   +1 more source

Combined antifungal resistance and biofilm tolerance: the global threat of Candida auris [PDF]

, 2019
The enigmatic yeast Candida auris has emerged over the last decade and rapidly penetrated our consciousness. The global threat from this multidrug-resistant yeast has generated a call to arms from within the medical mycology community.
Kean, Ryan, Ramage, Gordon
core   +2 more sources

Retrospective cohort study comparing the risk of severe hepatotoxicity in hospitalized patients treated with echinocandins for invasive candidiasis in the presence of confounding by indication

BMC Infectious Diseases, 2018
Background To compare the risk of severe hepatotoxicity with anidulafungin versus caspofungin and micafungin in hospitalized adults. Methods This retrospective cohort study combined data from two large US- based hospital electronic medical record ...
Francis Vekeman, Lisa Weiss, Jalal Aram, Raluca Ionescu-Ittu, Shahrzad Moosavi, Yongling Xiao, Wendy Y. Cheng, Rachel H. Bhak, Margaret Tawadrous, M. Rita Capparella, Philippe Montravers, Mei Sheng Duh   +11 more
doaj   +1 more source