Results 11 to 20 of about 25,158 (228)

Identification of potential autoantigens in anti-CCP-positive and anti-CCP-negative rheumatoid arthritis using citrulline-specific protein arrays

Scientific Reports, 2021
The presence or absence of autoantibodies against citrullinated proteins (ACPAs) distinguishes two main groups of rheumatoid arthritis (RA) patients with different etiologies, prognoses, disease severities, and, presumably, disease pathogenesis.
Thomas B. G. Poulsen, Dres Damgaard, Malene M. Jørgensen, Ladislav Senolt, Jonathan M. Blackburn, Claus H. Nielsen, Allan Stensballe   +6 more
doaj   +1 more source

Evidence of fibrinogen as a target of citrullination in IgM rheumatoid factor-positive polyarticular juvenile idiopathic arthritis

Pediatric Rheumatology Online Journal, 2011
Background Several studies have noted the significance of measuring anti-cyclic citrullinated peptide (CCP) antibodies in juvenile idiopathic arthritis (JIA) as an important indicator for destructive disease, as is the case in rheumatoid arthritis (RA ...
Dehlendorf Amanda B, Chauhan Anil K, Reed Melinda R, Gilliam Brooke E, Moore Terry L   +4 more
doaj   +1 more source

Identification of anti-citrullinated osteopontin antibodies and increased inflammatory response by enhancement of osteopontin binding to fibroblast-like synoviocytes in rheumatoid arthritis

Arthritis Research & Therapy, 2023
Background Anti-citrullinated protein/peptide antibodies (ACPAs) are present in patients at onset and have important pathogenic roles during the course of rheumatoid arthritis (RA).
Akio Umemoto, Takeshi Kuwada, Koichi Murata, Masahiro Shiokawa, Sakiko Ota, Yoshiki Murotani, Akihiro Itamoto, Kohei Nishitani, Hiroyuki Yoshitomi, Takayuki Fujii, Akira Onishi, Hideo Onizawa, Kosaku Murakami, Masao Tanaka, Hiromu Ito, Hiroshi Seno, Akio Morinobu, Shuichi Matsuda   +17 more
doaj   +1 more source

Characterization of Monoclonal Antibodies Recognizing Citrulline-Modified Residues

Frontiers in Immunology, 2022
BackgroundCitrullination is a post-translational protein modification linked to the occurrence and development of a variety of diseases. The detection of citrullinated proteins is predominately based on antibody detection although currently available ...
Yaqiong Chen, Lin Weng, Wei Liu, Chenxi Deng, Jinxiu Xuan, Yuan Ma, Cao Li, Jinlu Jiang, Juan Chen, Shengxiang Ge   +9 more
doaj   +1 more source

Structure and pathogenicity of antibodies specific for citrullinated collagen type II in experimental arthritis [PDF]

, 2009
Antibodies to citrulline-modifi ed proteins have a high diagnostic value in rheumatoid arthritis (RA). However, their biological role in disease development is still unclear.
Aho, Andersson, Auger, Baeten, Bella, Bettina Sehnert, Brunsberg, Burkhardt, Burkhardt, Bäcklund, Caspi, Chang, Chapuy-Regaud, Collaborative Computational Project, Number 4, DeLano, Dyson, Emsley, Emsley, Emsley, Estelle Bajtner, Foulquier, Girbal-Neuhauser, Giudicelli, Grab, Guy Serre, Harald Burkhardt, Hill, Hill, Hoffmann, Hüseyin Uysal, Kabsch, Kanazawa, Kidd, Krissinel, Kuhn, Kutty S. Nandakumar, Lefranc, Marjolein M.G.M. Thunnissen, Masson-Bessière, Masson-Bessière, Michaëlsson, Molberg, Murshudov, Nair, Nandakumar, Rantapää-Dahlqvist, Read, Reparon-Schuijt, Rikard Holmdahl, Robert Bockermann, Rosloniec, Schellekens, Schellekens, Schulte, Schwab, Stanfield, Stetefeld, Tarcsa, Uysal, van der Helm-van Mil, Vander Cruyssen, von Delwig, Vossenaar, Vossenaar, Vossenaar, Vossenaar, Winn, Yousfi Monod, Zong, Åke Engström   +69 more
core   +2 more sources

A Comprehensive Evaluation of the Relationship Between Different IgG and IgA Anti-Modified Protein Autoantibodies in Rheumatoid Arthritis

Frontiers in Immunology, 2021
Seropositive rheumatoid arthritis (RA) is characterized by the presence of rheumatoid factor (RF) and anti-citrullinated protein autoantibodies (ACPA) with different fine-specificities.
Caroline Grönwall, Lisa Liljefors, Holger Bang, Aase H. Hensvold, Aase H. Hensvold, Aase H. Hensvold, Monika Hansson, Linda Mathsson-Alm, Linda Mathsson-Alm, Lena Israelsson, Vijay Joshua, Anna Svärd, Anna Svärd, Ragnhild Stålesen, Philip J. Titcombe, Philip J. Titcombe, Johanna Steen, Luca Piccoli, Natalia Sherina, Cyril Clavel, Elisabet Svenungsson, Elisabet Svenungsson, Iva Gunnarsson, Iva Gunnarsson, Saedis Saevarsdottir, Saedis Saevarsdottir, Alf Kastbom, Guy Serre, Lars Alfredsson, Lars Alfredsson, Vivianne Malmström, Johan Rönnelid, Anca I. Catrina, Anca I. Catrina, Anca I. Catrina, Karin Lundberg, Lars Klareskog, Lars Klareskog, Lars Klareskog   +38 more
doaj   +1 more source

Autophagy generates citrullinated peptides in human synoviocytes: a possible trigger for anti-citrullinated peptide antibodies [PDF]

, 2016
OBJECTIVES: Autophagy may represent a functional processing event that creates a substrate for autoreactivity. In particular, autophagy may play a role in the pathogenesis of RA, since autophagy is a key cellular event involved in the generation of ...
Alessandra Nerviani, Antonella Capozzi, Cristiano Alessandri, Cristina Iannuccelli, Emanuela Lococo, Guido Valesini, Kato, Manuela Di Franco, Maurizio Sorice, Michele Bombardieri, Neumann, Pickl, Roberta Misasi, Tina Garofalo, Valeria Manganelli   +14 more
core   +1 more source

Serum reactivity to citrullinated protein/peptide antigens and left ventricular structure and function in the Multi-Ethnic Study of Atherosclerosis (MESA).

PLoS ONE, 2023
BackgroundAntibodies to citrullinated protein antigens have been linked to altered left ventricular (LV) structure and function in patients with rheumatoid arthritis (RA).
Jan M Hughes-Austin, Ronit Katz, Darcy S Majka, Michael H Criqui, William H Robinson, Gary S Firestein, W Gregory Hundley, Joachim H Ix   +7 more
doaj   +1 more source

Effect of Etanercept on anti-carbamylated protein antibodies in patients with rheumatoid arthritis [PDF]

, 2015
Rheumatoid Arthritis (RA) is a systemic, chronic inflammatory disease characterized by inflammation of synovial joints and production of autoantibodies such as Rheumatoid Factor and antibodies directed against modified proteins - i.e.
Alessandri, Cristiano, Ceccarelli, Fulvia, Conti, Fabrizio, Pecani, Arbi, Spinelli, FRANCESCA ROMANA   +4 more
core   +1 more source

Detection of salivary citrullinated cytokeratin 13 in healthy individuals and patients with rheumatoid arthritis by proteomics analysis.

PLoS ONE, 2022
The immune response to citrullinated peptides in the mucosa has been suggested to play an important role in the transition from pre-onset rheumatoid arthritis (RA) to clinically evident RA.
Takuya Yasuda, Koichiro Tahara, Tetsuji Sawada   +2 more
doaj   +2 more sources