Results 1 to 10 of about 8,957 (228)

Characterization and Localization of Citrullinated Proteoglycan Aggrecan in Human Articular Cartilage. [PDF]

PLoS ONE, 2016
BackgroundRheumatoid arthritis (RA) is an autoimmune disease of the synovial joints. The autoimmune character of RA is underscored by prominent production of autoantibodies such as those against IgG (rheumatoid factor), and a broad array of joint tissue ...
Tibor T Glant, Timea Ocsko, Adrienn Markovics, Zoltan Szekanecz, Robert S Katz, Tibor A Rauch, Katalin Mikecz   +6 more
doaj   +3 more sources

A Tolerogenic Plasmid Inhibits Autoantibody Production Triggered by Immunization With Human Peptidyl Arginine Deiminase 4. [PDF]

Arthritis Rheumatol
Objective Rheumatoid arthritis (RA) is usually preceded and likely mediated by autoantibodies to citrullinated proteins (ACPAs) that recognize citrulline residues on multiple proteins. Conversion of arginine into citrulline is performed by enzymes called peptidyl arginine deiminases (PADs). We have previously demonstrated that the human PAD4 (hPAD4) is
Pagni PP, Kumar V, Lambert NC, Frison E, Luche H, Mello M, Torres M, Wesley JD, von Herrath M, Roudier J, Auger I.   +10 more
europepmc   +2 more sources

Restoring Immunological Tolerance via Dendritic Cells in Rheumatoid Arthritis. [PDF]

Eur J Immunol
This review examines the failure of peripheral immune tolerance as the initiating factor in rheumatoid arthritis (RA), focusing on the role of dendritic cells. It discusses strategies to convert these cells from immunogenic to tolerogenic states, while also exploring emerging research on the anatomical sites where this critical loss of tolerance occurs.
Costello H, Woodcock A, Canavan M.
europepmc   +2 more sources

Identification of autoantibodies targeting citrullinated CLEC12A in rheumatoid arthritis patients [PDF]

Journal of Translational Autoimmunity
Objective: Rheumatoid arthritis is an autoimmune disease characterized by anti-citrullinated protein antibodies (ACPA). The pathogenic and protective roles of ACPA of distinct specificities are emerging and remains poorly understood.
Lillian Barra, Sheri Saunders, Mathias Mangion, Guillaume Paré, Halim Maaroufi, Alain Garnier, Ewa Cairns, Maria J. Fernandes   +7 more
doaj   +2 more sources

Relationship between anti-Epstein-Barr virus early antigen diffuse type and restricted type immunoglobulin G antibodies and disease activity and autoantibodies in rheumatoid arthritis: a retrospective observational study [PDF]

BMC Rheumatology
Background This study examined to examine the relationship of Epstein-Barr virus (EBV) in rheumatoid arthritis (RA) by evaluating disease activity and autoantibody levels in positive and negative cases using the anti-EBV early antigen diffuse type and ...
Noboru Kitamura, Yosuke Nagasawa, Kumiko Akiya, Hirotake Inomata, Hideki Nakamura   +4 more
doaj   +2 more sources

ACPA-Induced ATP release and K+ efflux trigger NLRP3 inflammasome activation in rheumatoid arthritis [PDF]

Cell Communication and Signaling
Objectives Anti-citrullinated protein antibodies (ACPA) is one of the key inducers of the initiation and maintenance of the immune-inflammatory response in Rheumatoid arthritis (RA), yet evidence is lacking on how ACPA drives the inflammatory response ...
Li Cai, Kai Zhang, Jian Gao, Bing Xiao, Meng Li, Xiangyun Meng, Zhipeng Chen, Xiaoling Chen, Shixian Chen, Juan Li   +9 more
doaj   +2 more sources

Periodontal Pathogens Correlate with Rheumatoid Arthritis Disease Parameters: A Systematic Review Based on Clinical Studies [PDF]

Dentistry Journal
Background: Numerous studies have found higher levels of autoantibodies including anti citrullinated protein antibodies (ACPAs), anti-cyclic citrullinated peptides (aCCP), or rheumatoid factor (RF) against periodontal microorganisms in rheumatoid ...
Luki Astuti, Sri Lelyati Chaidar Masulili, Indrayadi Gunardi, Benso Sulijaya, Yuniarti Soeroso   +4 more
doaj   +2 more sources

Antibodies to a Citrullinated Porphyromonas gingivalis Epitope Are Increased in Early Rheumatoid Arthritis, and Can Be Produced by Gingival Tissue B Cells: Implications for a Bacterial Origin in RA Etiology

Frontiers in Immunology, 2022
Based on the epidemiological link between periodontitis and rheumatoid arthritis (RA), and the unique feature of the periodontal bacterium Porphyromonas gingivalis to citrullinate proteins, it has been suggested that production of anti-citrullinated ...
Natalia Sherina, Charlotte de Vries, Nastya Kharlamova, Natalie Sippl, Xia Jiang, Boel Brynedal, Elin Kindstedt, Elin Kindstedt, Monika Hansson, Linda Mathsson-Alm, Linda Mathsson-Alm, Lena Israelsson, Ragnhild Stålesen, Saedis Saevarsdottir, Saedis Saevarsdottir, Rikard Holmdahl, Aase Hensvold, Aase Hensvold, Gunnar Johannsen, Gunnar Johannsen, Kaja Eriksson, Kaja Eriksson, Federica Sallusto, Federica Sallusto, Anca I. Catrina, Anca I. Catrina, Johan Rönnelid, Caroline Grönwall, Tülay Yucel-Lindberg, Tülay Yucel-Lindberg, Lars Alfredsson, Lars Alfredsson, Lars Klareskog, Luca Piccoli, Vivianne Malmström, Khaled Amara, Karin Lundberg   +36 more
doaj   +1 more source

How RA Associated HLA-DR Molecules Contribute to the Development of Antibodies to Citrullinated Proteins: The Hapten Carrier Model

Frontiers in Immunology, 2022
The risk to develop ACPA positive rheumatoid arthritis (RA), the most destructive type of autoimmune arthritis, is carried by HLA-DRB1 alleles containing a 5 amino acid motif: the shared epitope (SE).
Jean Roudier, Jean Roudier, Jean Roudier, Nathalie Balandraud, Nathalie Balandraud, Isabelle Auger, Isabelle Auger   +6 more
doaj   +1 more source

Immune Recognition of Citrullinated Proteoglycan Aggrecan Epitopes in Mice with Proteoglycan-Induced Arthritis and in Patients with Rheumatoid Arthritis. [PDF]

PLoS ONE, 2016
Rheumatoid arthritis (RA) is an autoimmune inflammatory disease affecting the joints. Anti-citrullinated protein antibodies (ACPA) are frequently found in RA.
Adrienn Markovics, Tímea Ocskó, Robert S Katz, Edit I Buzás, Tibor T Glant, Katalin Mikecz   +5 more
doaj   +1 more source