Results 11 to 20 of about 8,957 (228)

Adalimumab-Induced Rhupus Syndrome in a Female Patient Affected with Anti-Citrullinated Protein Antibody (ACPA)-Positive Rheumatoid Arthritis (RA): A Case Report and Review of Literature [PDF]

Clinics and Practice, 2021
We report a 38-year-old female patient affected with anti-citrullinated protein antibody (ACPA)-positive rheumatoid arthritis (RA) who developed mild hemolytic anemia (Hb = 10.5 vs. >12 gr/dL), indolent oral ulceration, ANA (1:1280, homogeneous pattern),
Ciro Manzo, Alberto Castagna
doaj   +3 more sources

The role of anti-citrullinated protein antibodies (ACPA) in the pathogenesis of rheumatoid arthritis. [PDF]

Cent Eur J Immunol, 2017
The most specific autoimmunity known for rheumatoid arthritis (RA) is reflected by generation of anti-citrullinated protein antibodies (ACPA). Presence of ACPA in established RA is associated with disease severity, while generation of ACPA at early developmental phases of RA can have a strong predictive value for progressing to the full-blown disease ...
Kurowska W, Kuca-Warnawin EH, Radzikowska A, Maśliński W.   +3 more
europepmc   +3 more sources

Platelets derived citrullinated proteins and microparticles are potential autoantibodies ACPA targets in RA patients

Frontiers in Immunology, 2023
Citrullinated neoepitopes have emerged as key triggers of autoantibodies anti-citrullinated protein antibodies (ACPA) synthesis in rheumatoid arthritis (RA) patients.
Minjie Xu, Rong Du, Wenping Xing, Xueting Chen, Jian Wan, Shengqing Wang, Li Xiong, Kutty Selva Nandakumar, Rikard Holmdahl, Hui Geng   +9 more
doaj   +1 more source

Identification of potential autoantigens in anti-CCP-positive and anti-CCP-negative rheumatoid arthritis using citrulline-specific protein arrays

Scientific Reports, 2021
The presence or absence of autoantibodies against citrullinated proteins (ACPAs) distinguishes two main groups of rheumatoid arthritis (RA) patients with different etiologies, prognoses, disease severities, and, presumably, disease pathogenesis.
Thomas B. G. Poulsen, Dres Damgaard, Malene M. Jørgensen, Ladislav Senolt, Jonathan M. Blackburn, Claus H. Nielsen, Allan Stensballe   +6 more
doaj   +1 more source

Reactivity of Rheumatoid Arthritis-Associated Citrulline-Dependent Antibodies to Epstein-Barr Virus Nuclear Antigen1-3

Antibodies, 2022
Rheumatoid arthritis (RA) is a chronic disease which causes joint inflammation and, ultimately, erosion of the underlying bone. Diagnosis of RA is based on the presence of biomarkers, such as anti-citrullinated protein antibodies (ACPA) and rheumatoid ...
Ilaria Fanelli, Paolo Rovero, Paul Robert Hansen, Jette Lautrup Frederiksen, Gunnar Houen, Nicole Hartwig Trier   +5 more
doaj   +1 more source

Biosensor analysis of anti-citrullinated protein/peptide antibody affinity [PDF]

Analytical Biochemistry, 2014
Anti-citrullinated protein/peptide antibodies (ACPAs) are detected in rheumatoid arthritis (RA) sera and because of their strict association with the disease are considered marker antibodies, probably endowed with pathogenic potential. Antibody affinity is one of the parameters affecting pathogenicity.
ROSSI, GIADA, REAL FERNANDEZ, FELICIANA, Filomena Panza, Francesca Barbetti, Federico Pratesi, ROVERO, PAOLO, Paola Migliorini   +6 more
openaire   +3 more sources

Are antibodies to fine specificities of citrullinated peptides/proteins useful for stratification of rheumatoid arthritis patients?

Clinical & Translational Immunology, 2021
Background In rheumatoid arthritis (RA), antibodies to citrullinated protein (ACPA) are believed to be heterogeneous and patient stratification by antibody profiling raised clinical interest for patient management.
Leonor Nogueira, Emilie Parra, Margaux Larrieu, Evelyne Verrouil, Martin Cornillet   +4 more
doaj   +1 more source

FRI0519 IDENTIFICATION OF CELLULAR TARGETS FOR ANTI-CITRULLINATED PROTEIN ANTIBODIES (ACPAS) [PDF]

Annals of the Rheumatic Diseases, 2019
Background Autoantibodies against citrullinated proteins (ACPAs) have been suggested to play important roles in RA pathogenesis (1-3). Objectives In order to further dissect how ACPAs influence bone homeostasis and inflammation in the joints we analyzed the binding of different ACPA clones to target antigens produced by synovial fibroblasts ...
Bence Réthi, Meng Sun, Alexandra Circiumaru, Akilan Krishnamurthy, Heidi Wähämaa, Jimmy Ytterberg, Vivianne Malmström, Lars Klareskog, Anca Catrina   +8 more
openaire   +1 more source

Anti-citrullinated Protein Antibody Generation, Pathogenesis, Clinical Application, and Prospects

Frontiers in Medicine, 2022
Anti-citrullinated protein antibodies (ACPAs) are autoantibodies commonly observed in patients with rheumatoid arthritis (RA). Currently, most of the mechanisms of ACPA formation and bone destruction are well-understood, however, some unknown mechanisms ...
Jiaxi Liu, Jinfang Gao, Zewen Wu, Liangyu Mi, Na Li, Yajing Wang, Xinyue Peng, Ke Xu, Fengping Wu, Liyun Zhang   +9 more
doaj   +1 more source

The fine specificity of IgM anti-citrullinated protein antibodies (ACPA) is different from that of IgG ACPA [PDF]

Arthritis Research & Therapy, 2011
Abstract Introduction The antigen recognition pattern of immunoglobulin M (IgM) could, when directed against protein antigens, provide an indication of the antigenic moieties triggering new B cells. The half-life of IgM is short and memory B cells against T-cell-dependent protein antigens typically ...
Suwannalai, Parawee; Willemze, Annemiek; van Toorn, Linda; Stoeken-Rijsbergen, Gerrie; Levarht, Nivine; Drijfhout, Jan Wouter; Huizinga, Tom W. J.; Toes, Rene E. M.; Trouw, Leendert A.   +9 more
openaire   +3 more sources