PLoS ONE, 2022 A series of newer previously synthesized fluorinated chalcones and their 2-amino-pyridine-3-carbonitrile and 2-amino-4H-pyran-3-carbonitrile derivatives were screened for their in vitro antitubercular activity and in silico methods.
Surendra Babu Lagu +7 more
semanticscholar +4 more sources
Molecules, 2023 Novel antitubercular compounds are urgently needed to combat drug-resistant Mycobacterium tuberculosis (Mtb). Filamentous actinobacteria have historically been an excellent source of antitubercular drugs.
D. Watson +4 more
semanticscholar +3 more sources
Inhalable fucoidan microparticles combining two antitubercular drugs with potential application in pulmonary tuberculosis therapy [PDF]
Polymers, 2018 The pulmonary delivery of antitubercular drugs is a promising approach to treat lung tuberculosis. This strategy not only allows targeting the infected organ instantly, it can also reduce the systemic adverse effects of the antibiotics. In light of that,
Ana Grenha +7 more
core +3 more sources
Mycobacterium tuberculosis IMPDH in Complexes with Substrates, Products and Antitubercular Compounds [PDF]
PLoS ONE, 2015 Tuberculosis (TB) remains a worldwide problem and the need for new drugs is increasingly more urgent with the emergence of multidrug- and extensively-drug resistant TB.
M. Makowska-Grzyska +14 more
semanticscholar +2 more sources
Early Drug Development and Evaluation of Putative Antitubercular Compounds in the -Omics Era
Frontiers in Microbiology, 2021 Tuberculosis (TB) is an infectious disease caused by the bacterium Mycobacterium tuberculosis. According to the WHO, the disease is one of the top 10 causes of death of people worldwide.
A. Minias +7 more
semanticscholar +3 more sources
Host Antimicrobial Peptides: the promise of new treatment strategies against Tuberculosis [PDF]
Frontiers in Immunology, 2017 Tuberculosis (TB) continues to be a devastating infectious disease and remerges as a global health emergency due to an alarming rise of antimicrobial resistance to its treatment.
Abedinzadeh +217 more
core +4 more sources
Total Synthesis and Structural Reassignment of the Antitubercular Natural Product Evybactin [PDF]
ChemistryThe escalating threat posed by antibiotic resistance is a global concern and underscores the need for new antibiotics. In this context, the recent discovery of evybactin, a nonribosomal depsipeptide antibiotic that selectively and potently inhibits the ...
Vladyslav Lysenko +9 more
semanticscholar +2 more sources
Stroke Mimicry: Unmasking a Brainstem Tuberculoma in a Young Patient. [PDF]
Clin Case RepA young male presented with stroke‐like symptoms ‐ progressive hemiparesis and cranial nerve palsies. MRI brain revealed a ring‐enhancing intrapontine lesion with perilesional edema, suggestive of tuberculoma. Early initiation of anti‐tubercular therapy led to complete recovery.
Palanisamy NN +5 more
europepmc +2 more sources
Drug induced liver injury: East versus West – a systematic review and meta-analysis [PDF]
Clinical and Molecular Hepatology, 2020 Drug induced liver injury (DILI) may be different in the East compared to the West due to differing disease prevalence, prescribing patterns and pharmacogenetic profiles.
En Xian Sarah Low +3 more
doaj +1 more source
A Case Report on Disseminated Tuberculosis in a Newborn [PDF]
Pediatric Infectious Disease, 2023 Congenital tuberculosis (CTB) is a rare and challenging diagnosis with high mortality. As one of the many differentials for newborn sepsis, it should be considered when neonates deteriorate despite broad-spectrum antibiotics.
Sachin Bhagat +2 more
doaj +1 more source