Results 51 to 60 of about 6,983 (163)

VanA Mediated Glycopeptide Resistant Enterococcus faecium (GRE) Infection in an Elderly Patient with Chronic Kidney Disease – A Case Report [PDF]

Journal of Clinical and Diagnostic Research, 2018
A 66-year-old male patient who is a known case of chronic kidney disease was admitted to the hospital with complaint of seizures. He was uremic and showed signs of encephalopathy.
Martin Jane Esther, PK Rath, R Gopalakrishnan   +2 more
doaj   +1 more source

Unusual Presentation of Subcutaneous Panniculitis‐Like T‐Cell Lymphoma

Clinical Case Reports, Volume 13, Issue 12, December 2025.
ABSTRACT Subcutaneous panniculitis‐like T‐cell lymphoma (SPTCL) is a rare variant of primary cutaneous T‐cell lymphoma primarily affecting subcutaneous adipose tissue and mimicking lobular panniculitis. It often presents with erythematous subcutaneous nodules or plaques, and diagnosis can be challenging due to its diverse clinical manifestations.
Mona Alkallabi, Hend Alotaibi, Khalid Nabil Nagshabandi, Reem Bin Idris, Amal H. Abualola, Naif Ahmed Alshehri, Ahmed Alhumidi   +6 more
wiley   +1 more source

Drug Design and Delivery for Intracellular Bacteria: Emerging Paradigms

Drug Development Research, Volume 86, Issue 8, December 2025.
ABSTRACT Intracellular bacteria exploit host cell niches, such as lysosomes, phagosomes, cytosol, entire cells, and even erythrocytes, to evade immune clearance and escape conventional antibiotics. These environments pose numerous therapeutic challenges, including crossing host cell membranes, navigating endosomal trafficking, tolerating acidic and ...
Babatunde Ibrahim Olowu, Maryam Ebunoluwa Zakariya, Abdulmuheez Abiola Abdulkareem, Olalekan Toheeb Okewale, Muhammad Halima Idris, Halimah Oluwayemisi Olayiwola   +5 more
wiley   +1 more source

Uncovering Insights Into the Biology of Mycobacterium tuberculosis Using Genetic Tools

MicrobiologyOpen, Volume 14, Issue 6, December 2025.
Genetic manipulation tools such as homologous recombination, CRISPR‐Cas systems, and gene knock‐out/knock‐down strategies have advanced Mycobacterium tuberculosis (Mtb) research, despite challenges posed by its slow growth, complex pathology, and drug resistance.
Alessandro Stamilla, Deborah Recchia, Giovanni Stelitano, Ludovica Maci, Maria Concetta Marturano, Edda De Rossi, Laurent Roberto Chiarelli, Maria Rosalia Pasca, Giulia Degiacomi   +8 more
wiley   +1 more source

Antimicrobial resistance from a One Health perspective in Zambia: a systematic review

Antimicrobial Resistance and Infection Control, 2023
Background Antimicrobial resistance (AMR) is widely acknowledged as a global health problem, yet its extent is not well evaluated, especially in low-middle income countries.
Avis A. Nowbuth, Akwi W. Asombang, Nkengeh N. Tazinkeng, Opeoluwa Y. Makinde, Lincoln R. Sheets   +4 more
doaj   +1 more source

Drug-Induced Musculoskeletal Syndromes and Soft-Tissue Rheumatism

Indian Journal of Rheumatology, 2019
Drug-induced musculoskeletal syndromes represent a broad clinical spectrum, ranging from asymptomatic biological abnormalities to severe organ-threatening manifestations. Many drugs have been implicated in inducing rheumatological adverse events.
Rudra Prosad Goswami, Parasar Ghosh
doaj   +1 more source

Advancing Tuberculosis Chemotherapy: Targeted Nanomedicines for the Mycobacterium TB Granuloma

Small, Volume 21, Issue 49, December 10, 2025.
This graphical abstract illustrates nanosystems used for targeted drug delivery into tuberculosis granulomas. It shows how targeting is influenced by size, pH, redox sensitivity, and surface charge. Various nanoparticles are incorporated with drugs to enhance penetration, stability, and release.
Shreya Ranjith Singh, Maya Mellisa Makatini, Thashree Marimuthu, Yahya Essop Choonara   +3 more
wiley   +1 more source

The Capacity of Mycobacterium tuberculosis To Survive Iron Starvation Might Enable It To Persist in Iron-Deprived Microenvironments of Human Granulomas

mBio, 2017
This study was conducted to investigate the role of iron deprivation in the persistence of Mycobacterium tuberculosis. We present evidence of iron restriction in human necrotic granulomas and demonstrate that under iron starvation M.
Krishna Kurthkoti, Hamel Amin, Mohlopheni J. Marakalala, Saleena Ghanny, Selvakumar Subbian, Alexandra Sakatos, Jonathan Livny, Sarah M. Fortune, Michael Berney, G. Marcela Rodriguez   +9 more
doaj   +1 more source

δ-Hydroxy-γ-oxo-L-norvaline, a New Antitubercular Antibiotic. (3). Structural Analogs ; their Structure and Antitubercular Actitvity.

Chemical and Pharmaceutical Bulletin, 1960
Sixteen homologs of L-HON were synthesized and their in vitro activity against M. tuberculosis was tested. From such results, L-HON was classified as a member of the group which is relatively low in molecular weight and active only against M. tuberculosis.
openaire   +2 more sources

Extrapolation of lung pharmacokinetics of bedaquiline across species using physiologically‐based pharmacokinetic modelling

British Journal of Clinical Pharmacology, Volume 91, Issue 11, Page 3167-3178, November 2025.
Aims Bedaquiline (BDQ) is a first‐in‐class diarylquinoline (DARQ) and a potent anti‐tuberculosis drug, vital in combating multi‐drug resistant tuberculosis (TB). Understanding its lung pharmacokinetics (PK) across species is crucial for effective clinical translation.
Evangelos Karakitsios, Oscar Della Pasqua, Aristides Dokoumetzidis   +2 more
wiley   +1 more source