Results 51 to 60 of about 951,869 (260)

The prodrug activator EtaA from Mycobacterium tuberculosis is a Baeyer-Villiger monooxygenase [PDF]

, 2004
EtaA is a newly identified FAD-containing monooxygenase that is responsible for activation of several thioamide prodrugs in Mycobacterium tuberculosis.
Fortin, R, Fraaije, M.W., Heidekamp, A.J, Janssen, D.B.   +3 more
core   +5 more sources

MEPicides: Potent antimalarial prodrugs targeting isoprenoid biosynthesis [PDF]

, 2017
The emergence of Plasmodium falciparum resistant to frontline therapeutics has prompted efforts to identify and validate agents with novel mechanisms of action. MEPicides represent a new class of antimalarials that inhibit enzymes of the methylerythritol
Brothers, Robert C, Dowd, Cynthia S, Edwards, Rachel L, Hruz, Paul W, Kraft, Thomas E, Maron, Maxim I, Odom John, Audrey R, Tsang, Patricia S, Wang, Xu, Williamson, Kim C, Ziniel, Peter D   +10 more
core   +2 more sources

Spontaneous mutations conferring antibiotic resistance to antitubercular drugs at a range of concentrations in Mycobacterium smegmatis [PDF]

Drug Development Research, 2018
AbstractMycobacteria population can undergo mutations in their DNA sequence during replication, which if not repaired, would be transferred to future generations. In this study, in vitro spontaneous mutations in Mycobacterium smegmatis mc2155 (Msm) conferring resistance to isoniazid (INHr), rifampicin (RIFr), kanamycin (KANr) and streptomycin (STRr ...
Nyinoh, Iveren W, McFadden, Johnjoe
openaire   +3 more sources

DESM: portal for microbial knowledge exploration systems [PDF]

, 2015
Microorganisms produce an enormous variety of chemical compounds. It is of general interest for mi-crobiology and biotechnology researchers to have means to explore information about molecular and genetic basis of functioning of different microor-ganisms
Adil Salhi, Aleksandar Radovanovic, Ameerah Bokhari, Andre Antunes, Benoit Marchand, Bouma, Feras F. Lafi, Ghofran Othum, Intikhab Allam, John A. C. Archer, Katsuhiko Mineta, Magbubah Essack, Marta Filipa Simoes, Olaa A. Motwalli, Robert Hoehndorf, Salim Bougouffa, Sasaya, Soha Al Amoudi, Takashi Gojobori, Tariq Malas, Vladimir B. Bajic, Wayne, Xin Gao   +22 more
core   +1 more source

Cavitating Pulmonary Tuberculosis in a 3-year-old Child: A Case Report [PDF]

Indian Journal of Respiratory Care
Cavitating pulmonary tuberculosis (PTB) frequently occurs in adults and is uncommon in children. We report a case of a 3-year-old female child who presented with complaints of fever, cough, and poor weight gain.
Pushpa Kini, Manjunath Laxminarayana, Soham Bhunia   +2 more
doaj   +1 more source

Spina ventosa: An often missed diagnosis

Journal of Global Infectious Diseases, 2021
Rare and varied presentations of tuberculosis make it difficult for treating clinicians to arrive at the diagnosis. An adolescent female presented to the orthopedic outpatient department with slowly increasing swelling over the dorsum of the hand near ...
Ankur Agarwal, Sheetal Agarwal, Savitri Singh, Sumi Nandwani   +3 more
doaj   +1 more source

Multiple Cutaneous Tuberculous Abscess: A Case Report [PDF]

Journal of Clinical and Diagnostic Research, 2017
Cutaneous tuberculosis is a relatively rare form of extrapulmonary tuberculosis. It usually manifests secondary to haematogenous spread or from an underlying focus of infection. We report a case of multiple tuberculous abscesses without any primary focus.
Rahul Suna, Ramu Duttaluri
doaj   +1 more source

Ursolic and oleanolic acids as antimicrobial and immunomodulatory compounds for tuberculosis treatment [PDF]

, 2013
BACKGROUND: New alternatives for the treatment of Tuberculosis (TB) are urgently needed and medicinal plants represent a potential option. Chamaedora tepejilote and Lantana hispida are medicinal plants from Mexico and their hexanic extracts have shown ...
Adelina Jiménez-Arellanes, Brenda Marquina, Dulce Mata-Espinosa, Javier Torres, Jorge Cornejo-Garrido, Julieta Luna-Herrera, Mariana Meckes-Fischer, María Eugenia Castro-Mussot, Rogelio Hernández-Pando, Sonia López-García   +9 more
core   +1 more source

MmpL3 is the flippase for mycolic acids in mycobacteria [PDF]

, 2017
The defining feature of the mycobacterial outer membrane (OM) is the presence of mycolic acids (MAs), which, in part, render the bilayer extremely hydrophobic and impermeable to external insults, including many antibiotics.
Chng, Shu-Sin, Meshcheryakov, Vladimir A., Poce, Giovanna, Xu, Zhujun   +3 more
core   +1 more source

Dual‐Peptide Nanoplatform: Mesoporous Silica Nanoparticles Functionalized With a Cell‐Penetrating Peptide and Loaded With Rationally Designed Antimicrobial Peptides for Tuberculosis Therapy

Advanced Healthcare Materials, EarlyView.
Machine learning–guided engineering of a plectasin‐derived peptide yields DC05, a potent antimycobacterial candidate. Encapsulation into tuftsin‐functionalized mesoporous silica nanoparticles enhances intracellular delivery, stability, and activity against Mycobacterium tuberculosis while maintaining low cytotoxicity and minimal hemolysis. The combined
Christian S. Carnero Canales, Cesar Augusto Roque‐Borda, Ana Carolina Cerqueira Negri, Oswaldo Ramirez Delgado, Letícia Oliveira Catarin Nunes, Flávia Aparecida Resende, Hernane Barud, Norival Alves Santos‐Filho, Saulo Santesso Garrido, Karen Cristina Oliveira, Alexandra Ivo de Medeiros, Rafael Miguel Sábio, Fernando Rogério Pavan   +12 more
wiley   +1 more source