Results 21 to 30 of about 526,913 (304)

Affinity of anti-spike antibodies in SARS-CoV-2 patient plasma and its effect on COVID-19 antibody assays

EBioMedicine, 2022
Summary: Background: Measuring anti-spike protein antibodies in human plasma or serum is commonly used to determine prior exposure to SARS-CoV-2 infection and to assess the anti-viral protection capacity.
Patrick J. Macdonald, Qiaoqiao Ruan, Jessica L. Grieshaber, Kerry M. Swift, Russell E. Taylor, John C. Prostko, Sergey Y. Tetin   +6 more
doaj   +1 more source

Differences in affinity of monoclonal and naturally acquired polyclonal antibodies against Plasmodium falciparum merozoite antigens [PDF]

, 2015
Malaria is a major global cause of deaths and a vaccine is urgently needed.; We have employed the P. falciparum merozoite antigens MSP2-3D7/FC27 and AMA1, used them in ELISA, and coupled them in different ways using surface plasmon resonance (SPR) and ...
Stanisic, Danielle, Kironde, Fred, Danielle I. Stanisic, Anders, Robin F, Reddy, Sreenivasulu B, Persson, Kristina, Sreenivasulu B. Reddy, Cross, Nadia, Mats Wahlgren, Anders, Robin F., Cross, N, Beeson, James G, Wahlgren, M, Senn, Nicolas, Senn, N, Nicolas Senn, Kristina E.M. Persson, Reddy, SB, Stanisic, DI, Wahlgren, Mats, Nadia Cross, Fred Kironde, Beeson, JG, Persson, KEM, Mueller, Ivo, Reddy, Sreenivasulu B., Ivo Mueller, Peter M. Siba, Kironde, F, Siba, Peter M, Mueller, I, Siba, PM, Stanisic, Danielle I, Stanisic, Danielle I., Persson, Kristina,, Robin F. Anders, James G. Beeson, Siba, Peter M., Persson, Kristina E. M., Lund University., Beeson, James G., Anders, RF   +41 more
core   +1 more source

Enhancement of the neutralization ability resulting from a single amino acid change in the light chain of a chimeric antibody against SARS-CoV-2

Shanghai Jiaotong Daxue xuebao. Yixue ban, 2023
Objective·To screen the human-mouse chimeric antibodies that neutralize the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and analyse the key amino acid site changes in their light chain.Methods·Antibody heavy chain gene-humanized mice ...
YIN Zi, LIAN Chaoyang, GAO Bo, TIAN Ying, HAO Qian, YEAP Lengsiew   +5 more
doaj   +1 more source

Effect of trifluoroethanol on antibody reactivity against corresponding and nonrelated antigens [PDF]

The Ukrainian Biochemical Journal, 2018
The ability of antibodies to switch between specific and nonspecific recognition of antigens under various factors is the key issue. Here we demonstrate that 2,2,2-trifluoroethanol (TFE) is one of these factors influencing the ability of monoclonal ...
S. A. Bobrovnik, M. O. Demchenko, S. V. Komisarenko   +2 more
doaj   +1 more source

IgG Fc Affinity Ligands and Their Applications in Antibody-Involved Drug Delivery: A Brief Review

Pharmaceutics, 2023
Antibodies are not only an important class of biotherapeutic drugs, but also are targeting moieties for achieving active targeting drug delivery. Meanwhile, the rapidly increasing application of antibodies and Fc-fusion proteins has inspired the emerging
Chang Yang, Bing He, Hua Zhang, Xueqing Wang, Qiang Zhang, Wenbing Dai   +5 more
doaj   +1 more source

Targeting hepatocytes via the asialoglycoprotein-receptor [PDF]

, 2010
The asialoglycoprotein-receptor (ASGP-R) is a C-type lectin predominantly expressed on the sinusoidal surface of mammalian hepatocytes and is responsible for the blood-clearance of desialylated glycoproteins by receptormediated endocytosis.
Stokmaier, Daniela
core   +1 more source

Computational Model Reveals a Stochastic Mechanism behind Germinal Center Clonal Bursts

Cells, 2020
Germinal centers (GCs) are specialized compartments within the secondary lymphoid organs where B cells proliferate, differentiate, and mutate their antibody genes in response to the presence of foreign antigens.
Aurélien Pélissier, Youcef Akrout, Katharina Jahn , Jack Kuipers , Ulf Klein , Niko Beerenwinkel, María Rodríguez Martínez    +6 more
doaj   +1 more source

Boosting antibody responses to Plasmodium falciparum merozoite antigens in children with highly seasonal exposure to infection. [PDF]

, 2010
Longitudinal cohort studies are important to describe the dynamics of naturally acquired antibody response profiles to defined Plasmodium falciparum malaria antigens relative to clinical malaria episodes.
M. PINDER, Dunyo, S, Conway, DJ, O. J. AKPOGHENETA, D. J. CONWAY, Akpogheneta, OJ, Pinder, M, S. DUNYO   +7 more
core   +1 more source

Structure Based Affinity Maturation and Characterizing of SARS-CoV Antibody CR3022 against SARS-CoV-2 by Computational and Experimental Approaches

Viruses, 2022
The COVID-19 epidemic is raging around the world. Neutralizing antibodies are powerful tools for the prevention and treatment of SARS-CoV-2 infection. Antibody CR3022, a SARS-CoV neutralizing antibody, was found to cross-react with SARS-CoV-2, but its ...
Wei Yu, Nan Zhong, Xin Li, Jiayi Ren, Yueming Wang, Chengming Li, Gui Yao, Rui Zhu, Xiaoli Wang, Zhenxing Jia, Changwen Wu, Rongfeng Chen, Weihong Zheng, Huaxin Liao, Xiaomin Wu, Xiaohui Yuan   +15 more
doaj   +1 more source

Antibody-guided design and identification of CD25-binding small antibody mimetics using mammalian cell surface display

Scientific Reports, 2021
Small antibody mimetics that contain high-affinity target-binding peptides can be lower cost alternatives to monoclonal antibodies (mAbs). We have recently developed a method to create small antibody mimetics called FLuctuation-regulated Affinity ...
Kyra See, Tetsuya Kadonosono, Kotaro Miyamoto, Takuya Tsubaki, Yumi Ota, Marina Katsumi, Sumoe Ryo, Kazuki Aida, Misa Minegishi, Tatsuhiro Isozaki, Takahiro Kuchimaru, Shinae Kizaka-Kondoh   +11 more
doaj   +1 more source