Results 141 to 150 of about 84,044 (310)

Synthesis of a FTO inhibitor with anticonvulsant activity.

ACS Chemical Neuroscience, 2014
G. Zheng, Thomas Cox, Leah Tribbey, Gloria Z Wang, Paulina Iacoban, M. E. Booher, G. J. Gabriel, Lu Zhou, N-I. Bae, J. Rowles, Chuang He, M. Olsen   +11 more
semanticscholar   +1 more source

Artificial intelligence in preclinical epilepsy research: Current state, potential, and challenges

Epilepsia Open, EarlyView.
Abstract Preclinical translational epilepsy research uses animal models to better understand the mechanisms underlying epilepsy and its comorbidities, as well as to analyze and develop potential treatments that may mitigate this neurological disorder and its associated conditions. Artificial intelligence (AI) has emerged as a transformative tool across
Jesús Servando Medel‐Matus, Cesar Santana‐Gomez, Ruby G. Escalante, Dominique Duncan, Pedro F. Viana, Giulia Sofia Cereda, Naoto Kuroda, Aristea S. Galanopoulou   +7 more
wiley   +1 more source

Prenatal betamethasone–postnatal N‐methyl‐D‐aspartic acid model of spasms: Update on mechanisms and treatments

Epilepsia Open, EarlyView.
Abstract Infantile epilepsy spasms syndrome (IESS), formerly known as infantile spasms or West Syndrome, is a severe epilepsy syndrome affecting about 3 in 10,000 newborns in the United States. Characterized by clusters of epileptic spasms, interictal hypsarrhythmia, and developmental delays, IESS has diverse causes, including structural‐metabolic ...
Kayla Vieira, Antonia Schonwald, Chian‐Ru Chern, Kamya Shah, Jana Velíšková, Libor Velíšek   +5 more
wiley   +1 more source

Anticonvulsant Effects of Citronellal, Daidzin, and Phytol, Possibly Through GABA_A Receptor and Voltage-Gated Sodium Channel Interaction Pathways: In Vivo and In Silico Studies. [PDF]

Brain Behav
Mia E, Rahman MA, Shipon MNH, Mou MA, Mandal P, Rakib IH, Sayeed MA, Islam MT, Al Hasan MS, Ansari MA.   +9 more
europepmc   +1 more source

Status epilepticus: Updates on mechanisms and treatments

Epilepsia Open, EarlyView.
Abstract Status epilepticus (SE) consists of prolonged, self‐sustaining seizures and is a common neurological emergency that causes respiratory compromise and neuronal injury. Without prompt treatment, the seizures can become resistant to benzodiazepines, leading to the progressive evolution of established, refractory, and super‐refractory SE.
Suchitra Joshi, Jaideep Kapur
wiley   +1 more source

<i>E/Z</i> Isomerism of the Potential Antiepileptic Drug GIZH-298. [PDF]

Molecules
Mokrov GV, Litvinova SA, Biryukova VE, Voronina TA, Shorunov SV, Rebeko AG, Vorobyova TY, Grushevskaya LN, Sergeeva MS, Kuznetsov DN, Kravtsova OY, Nikitina EA, Gladysheva NA, Zhanataev AK, Durnev AD, Losev TV, Malashkeevich KM, Medvedev MG, Islamov MM, Lyssenko KA, Dorofeev VL.   +20 more
europepmc   +1 more source

Ketogenic diet for infantile epileptic spasms

Epilepsia Open, EarlyView.
Abstract Approximately half of all cases of Infantile Epileptic Spasms Syndrome (IESS) do not respond to vigabatrin and hormonal therapies. There is no clear consensus as to the second‐line therapy for IESS. Ketogenic diet (KD) has emerged as an effective treatment for certain drug‐resistant epilepsies and in many cases of IESS.
Morris H. Scantlebury, Anamika Choudhary, Andy Cheuk‐Him Ng, Cezar Gavrilovici   +3 more
wiley   +1 more source

Design, synthesis, and in vivo antiepileptic evaluation of novel quinazolinone-phthalimide derivatives. [PDF]

Sci Rep
Moradkhani F, Asadi M, Dehpour AR, Amini M, Amanlou M.   +4 more
europepmc   +1 more source

Epilepsy surgery: From bench to the clinics

Epilepsia Open, EarlyView.
Abstract Objective Recent advances in epilepsy surgery in patients with intractable epilepsy make it possible to study the mechanism of epilepsy in human brains. However, the true extent and propagation of each epileptogenic area from the epileptogenic focus in each patient is still difficult to perform “epilepsy cure” by surgery.
Tatsuya Tanaka
wiley   +1 more source

High Doses of Melatonin Induce Seizure-like Cortical Activity: Electrophysiological and Behavioral Evidence. [PDF]

ACS Omega
Almeida L, Lins A, Eiró-Quirino L, de Souza LV, Hamoy MKO, Hartcoff PFP, Brito MVDS, Barbosa GB, Reis TS, Hamoy M.   +9 more
europepmc   +1 more source