Results 21 to 30 of about 75,534 (305)
Searching for New Leads to Treat Epilepsy: Target-Based Virtual Screening for the Discovery of Anticonvulsant Agents [PDF]
, 2018 The purpose of this investigation is to contribute to the development of new anticonvulsant drugs to treat patients with refractory epilepsy. We applied a virtual screening protocol that involved the search into molecular databases of new compounds and ...
Bruno Blanch, Luis Enrique +8 more
core +2 more sources
Rational Polytherapy with Antiepileptic Drugs
Pharmaceuticals, 2010 Approximately 30–40% of patients do not achieve seizure control with a single antiepileptic drug (AED). With the advent of multiple AEDs in the past 15 years, rational polytherapy, the goal of finding combinations of AEDs that have favorable ...
Jong Woo Lee, Barbara Dworetzky
doaj +1 more source
Teratogenic Effects of Antiepileptic Drugs
Pediatric Neurology Briefs, 1997 Data from 5 prospective European studies totaling 1,221 children exposed to antiepileptic drugs (AED) during pregnancy and 158 children of unexposed control pregnancies were analyzed to quantify the risk of major congenital malformations (MCM) and are ...
J Gordon Millichap
doaj +1 more source
Acetazolamide in the treatment of acute mania - A case report [PDF]
, 1998 Several antiepileptic drugs are also being used in affective disorders. There are some hints that also the carbonic anhydrase inhibitor acetazolamide might be useful in the treatment of bipolar affective disorder.
Brandt, C. +3 more
core +1 more source
Antiepileptic drug-induced psychosis associated with MTHFR C677T: a case report
Journal of Medical Case Reports, 2019 Background Various antiepileptic drugs can potentially cause psychiatric side effects in patients with epilepsy, but the precise mechanism of these actions remains unknown.
Masaru Shimura +6 more
doaj +1 more source
Antiepileptic Drugs and Thyroid Function
Pediatric Neurology Briefs, 2004 Thyroid function in 78 girls and female adolescents (aged 8-18 years) during pubertal development was evaluated while taking carbamazepine (CBZ), oxcarbazepine (OXC), or valproate (VPA) monotherapy for epilepsy and after withdrawal of antiepileptic drugs,
J Gordon Millichap
doaj +1 more source
Current Therapeutic Research, 2020 : Background: Antiepileptic drugs are among the leading causes of drug-induced liver injury (DILI). Due to critical illness, children admitted to intensive care units are more prone to DILI.
Kannan Sridharan, MD, DM +3 more
doaj +1 more source
Behavioral Effects of Antiepileptic Drugs
Pediatric Neurology Briefs, 1989 Parental responses to a Child Behavior Checklist were compared before and after changing antiepileptic therapy in an open, parallel design study in the School of Pharmacy and Departments of Neurology and Pediatrics, School of Medicine, University of ...
J Gordon Millichap
doaj +1 more source
Early Withdrawal of Antiepileptic Drugs
Pediatric Neurology Briefs, 1998 Recurrence rate, risk factors for recurrence, and outcome in 161 children after early withdrawal of antiepileptic drugs (AEDs) were studied at Leiden University and other centers in The Netherlands.
J Gordon Millichap
doaj +1 more source
Modulation of neural cell membrane conductance by the herbal anxiolytic and antiepileptic drug aswal [PDF]
, 2000 To evaluate the effects of aswal on ionic fluxes and neuronal excitation, we performed extracellular and whole cell patch clamp recordings on CA1 pyramidal neurons of guinea pigs and Long-Evans rats.
Grunze, Heinz +3 more
core +1 more source