Results 11 to 20 of about 2,473,811 (360)

CD47 Deficiency Ameliorates Ocular Autoimmune Inflammation

Frontiers in Immunology, 2021
Autoimmune uveitis is a sight-threatening ocular inflammatory condition in which the retina and uveal tissues become a target of autoreactive immune cells.
Yoko Okunuki, Steven J. Tabor, May Y. Lee, Kip M. Connor   +3 more
doaj   +1 more source

Comprehensive single-cell analysis reveals novel anergic antigen-presenting cell subtypes in human sepsis

Frontiers in Immunology, 2023
BackgroundSepsis is a life-threatening condition with high mortality. A few studies have emerged utilizing single-cell RNA sequencing (scRNA-seq) to analyze gene expression at the single-cell resolution in sepsis, but a comprehensive high-resolution ...
Tuo Zhang, Guodong Lian, Guodong Lian, Wei Fang, Wei Fang, Lei Tian, Wenhao Ma, Jicheng Zhang, Jicheng Zhang, Zhaoli Meng, Zhaoli Meng, Hongna Yang, Hongna Yang, Chunting Wang, Chunting Wang, Chengguo Wei, Man Chen, Man Chen   +17 more
doaj   +1 more source

Dendritic Cells: The Long and Evolving Road towards Successful Targetability in Cancer

Cells, 2022
Dendritic cells (DCs) are a unique myeloid cell lineage that play a central role in the priming of the adaptive immune response. As such, they are an attractive target for immune oncology based therapeutic approaches.
Enrica Marmonti, Jacqueline Oliva-Ramirez, Cara Haymaker   +2 more
doaj   +1 more source

Mesothelial cell-derived antigen-presenting cancer-associated fibroblasts induce expansion of regulatory T cells in pancreatic cancer

bioRxiv, 2021
Multiple recent single cell RNA sequencing (scRNA-seq) studies have identified a unique cancer-associated fibroblast (CAF) population in pancreatic ductal adenocarcinoma (PDA) called antigen-presenting CAFs (apCAFs).
Huocong Huang, Zhaoning Wang, Yuqing Zhang, R. Brekken   +3 more
semanticscholar   +1 more source

Tumor Antigen Presentation by Dermal Antigen-Presenting Cells [PDF]

Journal of Investigative Dermatology, 2000
Several phenotypes of antigen-presenting cells are present in the dermis, where they presumably function to present encountered antigens for immune responses. This study examined the ability of dermal antigen-presenting cells to present tumor-associated antigens for the induction of in vivo antitumor immunity.
Edward Miranda, A. Lonati, H. Ozawa, Richard D. Granstein, Kristina Seiffert, Wanhong Ding, Stefan Beissert, Kristina Campton, Zengmin Yan   +8 more
openaire   +3 more sources

Antigen Presentation by Vascular Cells [PDF]

Frontiers in Immunology, 2017
Antigen presentation by cells of the vessel wall may initiate rapid and localized memory immune responses in peripheral tissues. Peptide antigens displayed on major histocompatibility complex (MHC) molecules on the surface of endothelial cells (ECs) can be recognized by T cell receptors on circulating effector memory T cells (TEM), triggering both ...
Rebecca Liu, Jordan S. Pober, Thomas D. Manes, Jonathan Merola   +3 more
openaire   +4 more sources

Astrocytes have the capacity to act as antigen-presenting cells in the Parkinson’s disease brain

Journal of Neuroinflammation, 2020
Background Many lines of evidence suggest that accumulation of aggregated alpha-synuclein (αSYN) in the Parkinson’s disease (PD) brain causes infiltration of T cells.
Jinar Rostami, Grammatiki Fotaki, Julien Sirois, Ropafadzo Mzezewa, J. Bergström, M. Essand, Luke M. Healy, A. Erlandsson   +7 more
semanticscholar   +1 more source

Daratumumab prevents programmed death ligand‐1 expression on antigen‐presenting cells in de novo multiple myeloma

Cancer Medicine, 2020
Background Daratumumab (Dara), an anti‐CD38 monoclonal antibody, has an immunologic mechanism of action through targeting of CD38 expressing immune cells in patients with multiple myeloma (MM). Furthermore, it was recently shown that CD38 upregulation in
Nicolas Stocker, Béatrice Gaugler, Laure Ricard, Frédéric deVassoigne, Zora Marjanovic, Mohamad Mohty, Florent Malard   +6 more
doaj   +1 more source

Increased genital mucosal cytokines in Canadian women associate with higher antigen-presenting cells, inflammatory metabolites, epithelial barrier disruption, and the depletion of L. crispatus

Microbiome, 2023
Background Cervicovaginal inflammation has been linked to negative reproductive health outcomes including the acquisition of HIV, other sexually transmitted infections, and cervical carcinogenesis. While changes to the vaginal microbiome have been linked
Christina Farr Zuend, Alana Lamont, Laura Noel-Romas, Samantha Knodel, Kenzie Birse, Kateryna Kratzer, Peter McQueen, Michelle Perner, Hossaena Ayele, Sarah Mutch, Alicia R. Berard, John J. Schellenberg, Faruk Senturk, Stuart McCorrister, Garrett Westmacott, Fran Mulhall, Bonnie Sandberg, Adelicia Yu, Margaret Burnett, Vanessa Poliquin, Adam D. Burgener   +20 more
doaj   +1 more source

Recent Advances in Experimental Dendritic Cell Vaccines for Cancer

Frontiers in Oncology, 2021
The development of immunotherapeutic methods for the treatment of oncological diseases have made it possible to improve the effectiveness of standard therapies.
Ivan Y. Filin, Kristina V. Kitaeva, Catrin S. Rutland, Albert A. Rizvanov, Valeriya V. Solovyeva   +4 more
doaj   +1 more source