Results 41 to 50 of about 2,473,811 (360)

Augmentation of T-cell activation by oscillatory forces and engineered antigen-presenting cells

bioRxiv, 2019
Activation of T cells by antigen presenting cells allows them to proliferate, produce cytokines, and kill infected or cancerous cells. We and others have shown that T cell receptors receive and in fact require mechanical forces from their own movements ...
Fatemeh S. Majedi, M. M. Hasani-Sadrabadi, T. Thauland, Song Li, L. Bouchard, M. Butte   +5 more
semanticscholar   +1 more source

Human dendritic cell functional specialization in steady state and inflammation

Frontiers in Immunology, 2014
Dendritic cells (DC) represent a heterogeneous population of antigen-presenting cells that are crucial in initiating and shaping immune responses. Although all DC are capable of antigen uptake, processing and presentation to T cells, DC subtypes differ ...
Arjan eBoltjes, Femke eVan Wijk
doaj   +1 more source

Biologically Inspired Design of Nanoparticle Artificial Antigen-Presenting Cells for Immunomodulation.

Nano letters (Print), 2017
Particles engineered to engage and interact with cell surface ligands and to modulate cells can be harnessed to explore basic biological questions as well as to devise cellular therapies.
J. Hickey, Fernando P Vicente, Gregory P. Howard, H. Mao, J. Schneck   +4 more
semanticscholar   +1 more source

Novel antigen-presenting cell imparts Treg-dependent tolerance to gut microbiota

Nature, 2022
Establishing and maintaining tolerance to self-antigens or innocuous foreign antigens is vital for the preservation of organismal health. Within the thymus, medullary thymic epithelial cells (mTECs) expressing autoimmune regulator (AIRE) have a critical ...
Blossom Akagbosu, Zakieh Tayyebi, Gayathri Shibu, Yoselin A Paucar Iza, Deeksha Deep, Y. Parisotto, Logan Fisher, H. Pasolli, Valentin Thevin, R. Elmentaite, M. Knott, S. Hemmers, L. Jahn, Christin Friedrich, Jacob G. Verter, Zhong-Min Wang, M. V. D. van den Brink, G. Gasteiger, T. G. Grünewald, J. Marie, C. Leslie, A. Rudensky, Chrysothemis C. Brown   +22 more
semanticscholar   +1 more source

The effect of artificial antigen-presenting cells with preclustered anti-CD28/-CD3/-LFA-1 monoclonal antibodies on the induction of ex vivo expansion of functional human antitumor T cells

Haematologica, 2008
Background Adoptive cell therapy with ex vivo expanded autologous antitumor cytotoxic T lymphocytes represents an important therapeutic option as an anticancer strategy.
Roberta Zappasodi, Massimo Di Nicola, Carmelo Carlo-Stella, Roberta Mortarini, Alessandra Molla, Claudia Vegetti, Salvatore Albani, Andrea Anichini, Alessandro M. Gianni   +8 more
doaj   +1 more source

The antigen presentation function of bone marrow-derived mast cells is spatiotemporally restricted to a subset expressing high levels of cell surface FcεRI and MHC II

BMC Immunology, 2010
Background At present, it is highly controversial whether pure mast cells can serve as antigen presenting cells, and it is not known whether the capacity of antigen presenting function is temporally restricted to a particular subset of differentiated ...
Sun Liangwu, Weng I-Chun, Croft Michael, Yang Ning-Sun, Gong Jian, Liu Fu-Tong, Chen Swey-Shen   +6 more
doaj   +1 more source

Establishing Preferred Product Characterization for the Evaluation of RNA Vaccine Antigens

Vaccines, 2019
The preferred product characteristics (for chemistry, control, and manufacture), in addition to safety and efficacy, are quintessential requirements for any successful therapeutic.
Cristina Poveda, Amadeo B. Biter, Maria Elena Bottazzi, Ulrich Strych   +3 more
doaj   +1 more source

Dynamics of cell-type transition mediated by epigenetic modifications [PDF]

arXiv, 2023
Maintaining tissue homeostasis requires appropriate regulation of stem cell differentiation. The Waddington landscape posits that gene circuits in a cell form a potential landscape of different cell types, wherein cells follow attractors of the probability landscape to develop into distinct cell types.
arxiv  

Tip cell overtaking occurs as a side effect of sprouting in computational models of angiogenesis [PDF]

BMC Systems Biology 2015, 9:86, 2015
During angiogenesis, endothelial cells compete for the tip position during angiogenesis: a phenomenon named tip cell overtaking. It is still unclear to what extent tip cell overtaking is a side effect of sprouting or to what extent a biological function.
arxiv   +1 more source

Jamming and force distribution in growing epithelial tissue [PDF]

Phys. Rev. Research 3, 023129 (2021), 2020
We investigate morphologies of proliferating cellular tissues using a newly developed numerical simulation model for mechanical cell division and migration in 2D. The model is applied to a bimodal mixture consisting of stiff cells with a low growth potential and soft cells with a high growth potential; cancer cells are typically considered to be softer
arxiv   +1 more source