Results 161 to 170 of about 49,482 (293)

Ethical and Regulatory Considerations in the Clinical Translation of Pluripotent Stem Cell‐Derived NK Cell Therapies

Cell Proliferation, EarlyView.
Advancements in the generation of human pluripotent stem cell‐derived natural killer (PSC‐NK) cells have attracted considerable attention within the biomedical research community, offering a promising off‐the‐shelf technique for universal immune therapy.
Qianwen Chen, Jianwei Lv, Xinwei Xie, Hanlin Zhu, Zhenyu Xiao, Yaojin Peng   +5 more
wiley   +1 more source

Leukemia Cell Surface Antigen Modulation Induced By Dual CD19/CD20 Chimeric Antigen Receptor (CAR)-T Cells [PDF]

Biology of Blood and Marrow Transplantation, 2017
Dina Schneider, Ying Xiong, Darong Wu, Volker Nolle, Sarah Schmitz, Andrew Kaiser, Boro Dropulic, Rimas Orentas   +7 more
openaire   +1 more source

Adjuvant therapy of severe and/or refractory bullous pemphigoid with immunoadsorption – A prospective monocenter pilot study

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Background and Objectives Bullous pemphigoid (BP) is the most common autoimmune blistering disease in the Western world. While remission is achieved in the majority of BP patients by long‐term use of corticosteroids with or without immunomodulants/immunosuppressants, national and international guidelines recommend adjuvant immunoadsorption (IA)
Maike M. Holtsche, Nina van Beek, Christoph M. Hammers, Artem Vorobyev, Michael Kasperkiewicz, Nina Schumacher, Philip Muck, Enno Schmidt   +7 more
wiley   +1 more source

Novel immunotherapies for immune-mediated haemolytic anaemia in dogs and people [PDF]

, 2015
Aerts, Ahmad, Andre, Baek, Baker, Baluna, Barcellini, Bardwell, Barker, Barker, Barker, Bennett, Berentsen, Bielekova, Brode, Brunkow, Buckner, Cancro, Cao, Castela, Corato, Den Otter, Desreumaux, Dieckmann, Dowling, Ellis, Forrester, Gagliani, Garden, Ginzler, Graca, Grant, Grundy, Haagsman, Haase, Hall, Hall, Han, Herzog, Heylmann, Hoffmann, Hori, Hori, Humrich, Impellizeri, Ito, James W Swann, Jubala, Jutel, Keiserman, Kim, Klatzmann, Knueppel, Kojima, Komatsu, Konietschke, Lutz, Mahevas, Mahevas, Marek-Trzonkowska, Mason, McCullough, Meiler, Miller, Miyara, Mouchess, Moyo, Mqadmi, Mueller, Oliver A Garden, Olivry, Packman, Penalver, Pinheiro, Polyak, Putnam, Reff, Reimer, Reynaud, Ring, Rodriguez, Rose, Rosenstein, Rue, Saadoun, Sabatos-Peyton, Sadlack, Sadlack, Sakaguchi, Schabowsky, Sharfe, Singer, Swann, Swann, Thornton, Tischner, Verhagen, Volkmann, Waldron-Lynch, Ward, Whitley, Wildin, Willerford, Wing, Xiao, Xu, Xu, Yadav, Zaja, Zanella, Zhao, Ziekman   +111 more
core   +2 more sources

Infections in Chronic Lymphocytic Leukemia: Evolving Risks and Prevention Strategies

European Journal of Haematology, EarlyView.
ABSTRACT Infections remain a leading cause of morbidity and mortality in patients with chronic lymphocytic leukemia (CLL), reflecting both intrinsic immune dysfunction and therapy‐related immunosuppression. The pathogenesis of immunodeficiency in CLL is multifactorial: neoplastic B cells impair humoral immunity, T cells are functionally exhausted, and ...
Enrica Antonia Martino, Santino Caserta, Ernesto Vigna, Antonella Bruzzese, Nicola Amodio, Eugenio Lucia, Virginia Olivito, Caterina Labanca, Francesco Mendicino, Fortunato Morabito, Massimo Gentile   +10 more
wiley   +1 more source

Primary cardiac T‐cell rich large B‐cell lymphoma causing aortic stenosis with metastasis in a Warmblood

Equine Veterinary Education, EarlyView.
Summary An 18‐year‐old Warmblood mare was presented to the Royal Veterinary College Equine Referral Hospital for investigation of progressive periocular and facial swelling, weight loss and tachycardia. Physical examination additionally identified bilateral pansystolic (grade 5/6 basilar left‐sided, 2/6 right‐sided), cardiac murmurs, submandibular ...
S. E. Talbot, F. Z. X. Lean, H. M. Martineau, B. Dunkel, J. Reed   +4 more
wiley   +1 more source

Conditional deletion of the multiple sclerosis susceptibility gene ATXN1 identifies cell‐autonomous effects in the B‐cell compartment

The FEBS Journal, EarlyView.
Ataxin‐1 is a polyglutamine protein associated with the etiology of spinocerebellar ataxia type 1 (SCA1) that has been recently found implicated in the risk of developing the autoimmune disorder multiple sclerosis (MS). Here, we took a conditional knockout approach to ablate ataxin‐1 exclusively in the B‐cell compartment and we found that this protein ...
Jonathan Jacob Carver, Rachael Riley Denbrock, Cindy Carolina Martines, Alessandro Didonna   +3 more
wiley   +1 more source

Immune cell infiltration correlates with intestinal permeability, inflammation, and gastrointestinal symptoms in type 1 diabetes

Journal of Diabetes Investigation, EarlyView.
In individuals with type 1 diabetes, immune cell infiltration in the colon mucosa tended to correlate with fecal and systemic markers of intestinal permeability and inflammation, as well as gastrointestinal symptoms. These findings suggest that low‐grade gut immune activation might link the intestinal barrier dysfunction with systemic endotoxin ...
Polina Zalizko, Reinis Isaks, Leonora Pahirko, Aleksejs Fedulovs, Eduards Krustins, Jurijs Nazarovs, Sergejs Dubencovs, Hanne Salmenkari, Markku Lehto, Kaspars Jēkabsons, Una Riekstiņa, Per‐Henrik Groop, Niina Sandholm, Jeļizaveta Sokolovska   +13 more
wiley   +1 more source

Sympathetic innervation of human cervical lymph nodes: A potential neuroimmunomodulatory target for the treatment of T‐cell‐driven autoimmune diseases like MS?

Journal of Anatomy, EarlyView.
Recent animal studies have shown that the sympathetic nervous system (SNS) prevents disease activity of EAE (Experimental autoimmune encephalomyelitis, animal model of Multiple Sclerosis [MS]), presumably through adrenergic activity in the deep cervical lymph nodes (DCLNs).
Christopher Kremer, Claire Mackaaij, Suzanne A. M. W. Verlinde‐Schellekens, Ronald L. A. W. Bleys, Cindy G. J. Cleypool   +4 more
wiley   +1 more source

Aberrant B cell responses as drivers of autoantibody generation and epitope diversification in SLE pathogenesis. [PDF]

Front Immunol
Tariq F, Charavanmuttu Y, Labiba K, Wincup C.   +3 more
europepmc   +1 more source