Results 11 to 20 of about 48,636 (310)

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology
Development of chimeric antigen receptor T‐cell therapy has revolutionized the treatment of B‐cell malignancies, although challenges such as antigen escape and tumor heterogeneity often decrease treatment success. Modular CARs targeting multiple antigens
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
doaj   +2 more sources

Monoclonal antibody-based therapies for Waldenström's macroglobulinemia

Leukemia Research Reports, 2022
Monoclonal antibodies have established an important role in the treatment armamentarium of hematological malignancies, including Waldenström's macroglobulinemia.
Despina Fotiou, Foteini Theodorakakou, Efstathios Kastritis   +2 more
doaj   +1 more source

Development of Stable CHO-K1 Cell Lines Overexpressing Full Length Human CD20 Antigen

Iranian Biomedical Journal, 2023
CD20 is a differentiation-related antigen exclusively expressed on the membrane of B lymphocytes. CD20 amplification is observed in numerous immune-related disorders, making it an ideal target for immunotherapy of hematological malignancies and autoimmune diseases.
Mohammadkhani, Niloufar, Rahimpour, Azam, Hoseinpoor, Reyhaneh, Rajabibazl, Masoumeh   +3 more
openaire   +2 more sources

Nanobody based dual specific CARs [PDF]

, 2018
Recent clinical trials have shown that adoptive chimeric antigen receptor (CAR) T cell therapy is a very potent and possibly curative option in the treatment of B cell leukemias and lymphomas.
Abken, Hinrich, Bonte, Sarah, De Munter, Stijn, Goetgeluk, Glenn, Ingels, Joline, Kerre, Tessa, Pille, Melissa, Vandekerckhove, Bart, Weening, Karin   +8 more
core   +2 more sources

Mesenchymal stem cells promote leukaemic cells aberrant phenotype from B-cell acute lymphoblastic leukaemia

Hematology/Oncology and Stem Cell Therapy, 2013
BACKGROUND AND OBJECTIVES: The role of bone marrow-mesenchymal stem cells (BM-MSC) in leukae-mic cell control is controversial. The purpose of this work was to evaluate BM-MSC role regarding the viability, proliferation and immunophenotype of normal B ...
Viviana M Rodríguez-Pardo, José A Aristizabal, Diana Jaimes, Sandra M Quijano, Iliana de los Reyes, María Victoria Herrera, Julio Solano, Jean Paul Vernot   +7 more
doaj   +1 more source

CD20 (Pan-B Cell Antigen) Expression on Bone Marrow-Derived T Cells [PDF]

American Journal of Clinical Pathology, 1996
Antibodies directed against CD20 (L26, Leu 16, and B1) are frequently used to determine the presence of B lymphocytes. However, recent publications describe the unexpected presence of CD20-positive T cells in the peripheral blood of normal subjects and occasional T-cell neoplasms that express CD20.
K M, Algino, R W, Thomason, D E, King, M M, Montiel, F E, Craig   +4 more
openaire   +2 more sources

Monoreactive high affinity and polyreactive low affinity rheumatoid factors are produced by CD5+ B cells from patients with rheumatoid arthritis. [PDF]

, 1988
In patients with rheumatoid arthritis (RA), circulating CD5+ B lymphocytes, but not CD5- B lymphocytes, are increased in number and size, exist in an activated state, spontaneously proliferate, and secrete Ig that binds to the Fc fragment of IgG.
Burastero, SE, Casali, P, Notkins, AL, Wilder, RL   +3 more
core   +1 more source

Monoclonal Antibodies: from Development to Clinical Application

Клиническая онкогематология, 2016
The development of monoclonal antibodies (MABs) resulted in revolutionary achievements in diagnosing and treating of oncohematological disorders. The review dwells on the history of the development and improved technologies for production of monoclonal ...
Yurii Ivanovich Budchanov
doaj   +1 more source

Immunotherapy in indolent Non-Hodgkin's Lymphoma

Leukemia Research Reports, 2022
Treatment of non-Hodgkin lymphoma (NHL) in general has improved over the years with the emergence of the monoclonal antibodies (MAB) therapy. NHL is divided into B cell NHL and T cell NHL. Treatment of NHL was based on the subtype of NHL and its staging.
Ghid Amhaz, Ali Bazarbachi, Jean El-Cheikh   +2 more
doaj   +1 more source

Emerging immunopharmacological targets in multiple sclerosis. [PDF]

, 2015
Inflammatory demyelination of the central nervous system (CNS) is the hallmark of multiple sclerosis (MS), a chronic debilitating disease that affects more than 2.5 million individuals worldwide. It has been widely accepted, although not proven, that the
Abdolmohamad Rostami, Abrams, Abrams, Achiron, Adelman, Allen, Bachmann, Bai, Bai, Baker, Balcer, Bar-Or, Bar-Or, Bar-Or, Bar-Or, Ben-Nun, Biasi, Bielekova, Bielekova, Bielekova, Bielekova, Bielekova, Bitar, Bluestone, Bogoljub Ciric, Bour-Jordan, Bourdette, Bourquin, Brambilla, Brocke, Burman, Burns, Burrows, Chaudhuri, Chitnis, Coles, Constantinescu, Constantinescu, Correale, Correale, Cox, Cragg, Crowe, Darlington, Darlington, Disanto, Duddy, Emery, Espinoza-Delgado, Faria, Faria, Farjam, Feinstein, Fissolo, Fletcher, Freedman, Garren, Garren, Garren, Garren, Giovannoni, Giovannoni, Girvin, Girvin, Goodin, Gosselin, Goverman, Goverman, Guang-Xian Zhang, Hale, Hartmann, Hauser, Havrdova, Hawker, He, Hedegaard, Higgins, Hill-Cawthorne, Hilliard, Hilliard, Ho, Hoffmann, Hofman, Jankovic, Jennum, Kappos, Kappos, Karussis, Karussis, Kearney, Kerbrat, Le Page, Li, Liblau, Lider, Lider, Lindsey, Lindsey, Lisak, Liu, Lobell, Lobell, Lohse, Lund, Lyons, Marrie, Marta, Martin, Mease, Medaer, Mestecky, Mikulkova, Miller, Milo, Mirshafiey, Mojtaba Farjam, Moreau, Mowat, Nicoletti, Nightingale, O'Brien, Offner, Offner, Oh, Oksenberg, Pender, Pettitt, Phillips, Phillips, Podojil, Poli, Pozzilli, Pryce, Quintana, Racioppi, Rasouli, Robinson, Rose, Rose, Rostami, Sandrini, Schaub, Sclerosis, Selmaj, Selmaj, Sinha, Smith, Spuler, Stuve, Taoufik, Tsunoda, Turley, Turley, Turner, van Boxel-Dezaire, van den Hoogen, Van der Walt, van Oosten, van Oosten, van Oosten, Vandenbark, Vandenbark, Viglietta, Viglietta, Vollmer, Walczak, Waldmann, Wang, Weber, Wefer, Weiner, Weiner, Weissert, Willis, Wucherpfennig, Wynn, Xing, Yadav, Zang, Zhang, Zhang, Zhang, Zhang   +182 more
core   +2 more sources