Results 41 to 50 of about 49,482 (293)

An oncolytic measles virus engineered to enter cells through the CD20 antigen

Molecular Therapy, 2003
We have earlier shown that attenuated measles virus (MV) has therapeutic potential as a replicating oncolytic virus in models of non-Hodgkin's lymphoma (NHL). In the current study, we investigated whether we could obtain replicating MVs capable of entering CD20(+) target cells through an interaction between a single-chain (scFv) anti-CD20 antibody and ...
Bucheit, Amanda D, Kumar, Shaji, Grote, Deanna M, Lin, Yukang, von Messling, Veronika, Cattaneo, Roberto B, Fielding, Adele K   +6 more
openaire   +2 more sources

Construction and evaluation of wild and mutant ofatumumab scFvs against the human CD20 antigen

Preparative Biochemistry & Biotechnology, 2022
Several monoclonal antibodies targeting the CD20 have been produced and Ofatumumab is a case in point. Although whole antibodies target cancer cells effectively, their applications are restricted in some ways. Single-chain fragment variable antibodies, rather than employing the entire structure of antibodies, have proven a practical approach for ...
Reza Maleki, Azam Rahimpour, Masoumeh Rajabibazl   +2 more
openaire   +2 more sources

CYTOTOXIC LYMPHOCYTES: THE ROLE IN INFLAMMATION IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE EXACERBATION AND REMISSION

Alʹmanah Kliničeskoj Mediciny, 2016
Background: Despite the number of publications related to the expression of surface antigens of periphery blood lymphocytes in chronic obstructive pulmonary disease (COPD), algorithm for interpreting of the results and implicating pathogene-tic ...
N. A. Raspopina, E. G. Shuganov, F. N. Paleev, Zh. M. Salmasi, A. E. Shuganov   +4 more
doaj   +1 more source

Major Histocompatibility Complex I and II Expression and Lymphocytic Subtypes in Muscle of Horses with Immune-Mediated Myositis. [PDF]

, 2016
BackgroundMajor histocompatibility complex (MHC) I and II expression is not normally detected on sarcolemma, but is detected with lymphocytic infiltrates in immune-mediated myositis (IMM) of humans and dogs and in dysferlin-deficient muscular dystrophy ...
Barnes, N, Durward-Akhurst, SA, Finno, CJ, Guo, LT, Shelton, GD, Shivers, J, Valberg, SJ   +6 more
core   +1 more source

Use of single-chain antibody derivatives for targeted drug delivery [PDF]

, 2016
Single-chain antibodies (scFvs), which contain only the variable domains of full-length antibodies, are relatively small molecules that can be used for selective drug delivery.
Ahmadzadeh, V., Erfani-Moghadam, V., Jaliani, H.Z., Khalili, M., Safdari, Y., Zarei, V.   +5 more
core   +1 more source

Development of a compact bidirectional promoter-driven dual chimeric antigen receptor (CAR) construct targeting CD19 and CD20 in the Sleeping Beauty (SB) transposon system

Journal for ImmunoTherapy of Cancer
Background A bidirectional promoter-driven chimeric antigen receptor (CAR) cassette provides the simultaneous expression of two CARs, which significantly enhances dual antigen-targeted CAR T-cell therapy.Methods We developed a second-generation CAR ...
Supannikar Tawinwung, Nattiya Hirankarn, Asmita Khaniya, S M Ali Hossieni Rad, Josh Halpin, Alexander McLellan, Koramit Suppipat   +6 more
doaj   +1 more source

Anti-CD20 Immunoglobulin G Radiolabeling with a 99mTc-Tricarbonyl Core: In Vitro and In Vivo Evaluations. [PDF]

PLoS ONE, 2015
In recent years, the diagnostic and therapeutic uses of radioisotopes have shown significant progress. Immunoglobulin (Ig) appears to be a promising tracer, particularly due to its ability to target selected antigens.
Hélène Carpenet, Armelle Cuvillier, Jacques Monteil, Isabelle Quelven   +3 more
doaj   +1 more source

CD20 and CD19 targeted vectors induce minimal activation of resting B lymphocytes [PDF]

, 2013
B lymphocytes are an important cell population of the immune system. However, until recently it was not possible to transduce resting B lymphocytes with retro- or lentiviral vectors, making them unsusceptible for genetic manipulations by these vectors ...
A Pezzutto, A Yoder, AD Bucheit, B Anliker, C Demaison, C Frecha, C Frecha, C Frecha, CA Walshe, Christian J. Buchholz, CJ Buchholz, D Unutmaz, DA Tuveson, DD Sloan, Els Verhoeyen, Evren Alici, François-Loic Cosset, H Li, H Niiro, J Bruenke, J Uchida, JT Golay, K Akashi, K Itoh, L Ginaldi, M Fujimoto, M Kügler, M Peipp, M Serafini, M Zanetti, MD Mühlebach, Michael Schwenkert, MJ Polyak, MS Cragg, NE Harwood, Q Zhou, Q Zhou, Q Zhou, Qi Zhou, R Zufferey, RC Münch, RN Damle, RS Noyce, S Funke, S Kheirallah, S Kneissl, Sabrina Kneissl, T Nakamura, TF Tedder, X Li, Y Reiter, YD Korin   +51 more
core   +3 more sources

Disease progression after R-CHOP treatment associated with the loss of CD20 antigen expression [PDF]

Revista Brasileira de Hematologia e Hemoterapia, 2010
A case of a follicular lymphoma transformed into a CD20(+) is described which progressed with the loss of CD20 expression after 8 cycles of R-CHOP. This phenomenon is not a rare event and has shown poor prognosis. Our purposes are to describe this event and suggest biopsy in relapsed or progressive disease.
Bellesso, Marcelo, Xavier, Flavia Dias, Costa, Renata Oliveira, Pereira, Juliana, Siqueira, Sheila Aparecida Coelho, Chamone, Dalton Alencar Fischer   +5 more
openaire   +5 more sources

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source