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Acquisition of cytotoxic T lymphocyte-specific carbohydrate differentiation antigens. [PDF]
The Journal of experimental medicine, 1985 Cytotoxic T cell (CTL)-specific activation antigens, termed CT determinants, have been detected by monoclonal antibodies (mAb) that inhibit CTL function. At the cell surface, the CT antigens are associated with the T200 glycoproteins and two other proteins of Mr 140,000 and 85,000 and are present on a secreted protein, gp155.
L, Lefrancois +3 more
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Marine Life Science & Technology, 2022 AbstractCluster of differentiation (CD) antigens are cell surface molecules expressed on leukocytes and other cells associated with the immune system. Antibodies that react with CD antigens are known to be one of the most essential tools for identifying leukocyte subpopulations.
Tian, Hong-fei +5 more
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Modulation of T-lymphocyte differentiation antigens: potential relevance for multiple sclerosis. [PDF]
Proceedings of the National Academy of Sciences, 1982 Effects of the anti-T-cell monoclonal antibodies OKT3, OKT5, and OKT8 on T-cell surface properties and cell functions were evaluated. Incubation of mononuclear cells isolated from peripheral blood for 48 hr with each monoclonal antibody in the absence of complement resulted in modulation of their respective surface antigens; i.e., the number of cells ...
J, Antel +4 more
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The Effect of Immunosuppressive Adjuvant Kynurenine on Type 1 Diabetes Vaccine
Frontiers in Immunology, 2021 Inducing antigen-specific tolerance is a promising treatment for preventing or reversing Type 1 diabetes (T1D). In contrast to a vaccine that induces immune responses against pathogens, a tolerogenic vaccine can suppress immunity against antigens causing
Jing Sun +12 more
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The role of immune checkpoints in cardiovascular disease
Frontiers in Pharmacology, 2022 Immune checkpoint inhibitors (ICI) are monoclonal antibodies which bind to immune checkpoints (IC) and their ligands to prevent inhibition of T-cell activation by tumor cells.
Laura I. Yousif +4 more
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Assessing in vitro and in vivo Trogocytosis By Murine CD4+ T cells
Bio-Protocol, 2020 Recognition of antigens by lymphocytes (B, T, and NK) on the surface of an antigen-presenting cell (APC) leads to lymphocyte activation and the formation of an immunological synapse between the lymphocyte and the APC.
Jim Reed, Scott Wetzel
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Human dendritic cells activated via dectin-1 are efficient at priming Th17, cytotoxic CD8 T and B cell responses. [PDF]
PLoS ONE, 2010 BACKGROUND: Dendritic cells capture antigens through PRRs and modulate adaptive immune responses. The type of adaptive immune T cell response generated is dependent upon the type of PRR activated by the microbes.
Sudhanshu Agrawal +2 more
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Frontiers in Immunology, 2022 BackgroundThe Human Cell Differentiation Molecules (HCDM) organizes Human Leukocyte Differentiation Antigen (HLDA) workshops to test and name clusters of antibodies that react with a specific antigen.
Daniela Kužílková +8 more
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Molecular Therapy: Oncolytics, 2021 Recently, oncolytic vaccinia viruses (VACVs) have shown their potential to provide for clinically effective cancer treatments. The reason for this clinical usefulness is not only the direct destruction of infected cancer cells but also activation of ...
Stephanie Riederer +5 more
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Genetic deletion of Mst1 alters T cell function and protects against autoimmunity. [PDF]
PLoS ONE, 2014 Mammalian sterile 20-like kinase 1 (Mst1) is a MAPK kinase kinase kinase which is involved in a wide range of cellular responses, including apoptosis, lymphocyte adhesion and trafficking.
Konstantin V Salojin +24 more
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