Results 11 to 20 of about 199,223 (187)

Genetic deletion of Mst1 alters T cell function and protects against autoimmunity. [PDF]

open access: yesPLoS ONE, 2014
Mammalian sterile 20-like kinase 1 (Mst1) is a MAPK kinase kinase kinase which is involved in a wide range of cellular responses, including apoptosis, lymphocyte adhesion and trafficking.
Konstantin V Salojin   +24 more
doaj   +1 more source

Enforced expression of the transcriptional coactivator OBF1 impairs B cell differentiation at the earliest stage of development. [PDF]

open access: yesPLoS ONE, 2008
OBF1, also known as Bob.1 or OCA-B, is a B lymphocyte-specific transcription factor which coactivates Oct1 and Oct2 on B cell specific promoters. So far, the function of OBF1 has been mainly identified in late stage B cell populations. The central defect
Alain Bordon   +7 more
doaj   +1 more source

The Role of Adaptor Proteins in the Biology of Natural Killer T (NKT) Cells

open access: yesFrontiers in Immunology, 2019
Adaptor proteins contribute to the selection, differentiation and activation of natural killer T (NKT) cells, an innate(-like) lymphocyte population endowed with powerful immunomodulatory properties.
Evelyn Gerth, Jochen Mattner
doaj   +1 more source

ZINC DEFICIENCY INDUCES FAS-MEDIATED APOPTOSIS

open access: yesМедицинская иммунология, 2014
. The aim of the present research was to study the expression of Fas-receptor and differentiation antigens CD3, CD4, CD8, CD16, CD20 on mononuclear cells of peripheral blood in the group of people with asimptomatic Zn-deficiency caused by geochemical ...
L. M. Karzakova
doaj   +1 more source

Production of Abzymes in Th, CBA, and C57BL/6 Mice before and after MOG Treatment: Comparing Changes in Cell Differentiation and Proliferation

open access: yesBiomolecules, 2019
Till yet there is no data concerning mechanisms of autoimmune diseases development. Experimental autoimmune encephalomyelitis (EAE) prone C57BL/6 (T- and B-lymphocyte response), non-autoimmune CBA, and Th mice with T cell response were immunized with ...
Kseniya S. Aulova   +11 more
doaj   +1 more source

The synergistic and enhancive effects of IL-6 and M-CSF to expand and differentiate functional dendritic cells from human monocytes under serum-free condition

open access: yesJournal of Biological Engineering, 2023
Background Dendritic cells (DCs) are differentiated from monocytes, and have a strong ability to perform phagocytosis, present antigens and activate T cell immune response.
Chao-Ling Yao, Tsung-Yu Tseng
doaj   +1 more source

Programmed Cell Death 1 (PD-1) and Cytotoxic T Lymphocyte-Associated Antigen 4 (CTLA-4) in Viral Hepatitis

open access: yesInternational Journal of Molecular Sciences, 2017
Virus-specific cluster of differentiation 8 (CD8+) cytotoxic T cells (CTL) recognize viral antigens presented on major histocompatibility complex (MHC) class I chains on infected hepatocytes, with help from CD4+ T cells.
Hyosun Cho   +3 more
semanticscholar   +1 more source

Diversification of Antitumour Immunity in a Patient with Metastatic Melanoma Treated with Ipilimumab and an IDO-Silenced Dendritic Cell Vaccine

open access: yesCase Reports in Medicine, 2016
Indoleamine 2,3-dioxygenase (IDO) expression in dendritic cells (DCs) inhibits T-cell activation and promotes T-cell differentiation into regulatory T-cells.
Mouldy Sioud   +5 more
doaj   +1 more source

New insights into Blimp-1 in T lymphocytes: a divergent regulator of cell destiny and effector function

open access: yesJournal of Biomedical Science, 2017
B lymphocyte-induced maturation protein-1 (Blimp-1) serves as a master regulator of the development and function of antibody-producing B cells. Given that its function in T lymphocytes has been identified within the past decade, we review recent findings
Shin-Huei Fu   +4 more
doaj   +1 more source

Measles Vaccines Designed for Enhanced CD8+ T Cell Activation

open access: yesViruses, 2020
Priming and activation of CD8+ T cell responses is crucial to achieve anti-viral and anti-tumor immunity. Live attenuated measles vaccine strains have been used successfully for immunization for decades and are currently investigated in trials of ...
Elena Busch   +13 more
doaj   +1 more source

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