Results 241 to 250 of about 156,998 (310)

Prognostic Impact of Histologic Subtypes in Mismatch Repair‐Deficient/Microsatellite Instability‐High Colorectal Cancer: A Single‐Center Retrospective Study of 1127 Stage 0–IV Patients

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Background Deficient mismatch repair/microsatellite instability‐High (dMMR/MSI‐H) colorectal cancer (CRC) generally confers a favorable survival yet is paradoxically enriched for poorly differentiated (Por) histology, which is linked to aggressive behavior.
Tomoyuki Momma, Hirokazu Okayama, Sohei Hayashishita, Hiroya Suzuki, Masanori Katagata, Takuro Matsumoto, Daisuke Ujiie, Shun Chida, Wataru Sakamoto, Koji Kono   +9 more
wiley   +1 more source

Harnessing mucosal immunity for protective vaccines. [PDF]

Nat Rev Immunol
Kwon DI, Bhagchandani SH, Ehrenzeller SA, Iwasaki A.   +3 more
europepmc   +1 more source

A Solution for Exosome‐Based Analysis: Surface‐Enhanced Raman Spectroscopy and Artificial Intelligence

Advanced Intelligent Discovery, EarlyView.
Exosomes are emerging as powerful biomarkers for disease diagnosis and monitoring. This review highlights the integration of surface‐enhanced Raman spectroscopy with artificial intelligence to enhance molecular fingerprinting of exosomes. Machine learning and deep learning techniques improve spectral interpretation, enabling accurate classification of ...
Munevver Akdeniz, Zakarya Al‐Shaebi, Omer Aydin   +2 more
wiley   +1 more source

Gut Dysbiosis and the Molecular Landscape of the Gut-Skin Axis: Comparative Insights and Therapeutic Implications for Atopic Dermatitis and Psoriasis. [PDF]

Cells
Andrzejczak K, Kucharczyk E, Sternak A, Busłowicz T, Ponikowska M.   +4 more
europepmc   +1 more source

Gorab deficiency in skin dermis accelerates aging and is associated with dysregulation of RCHY1‐mediated P53 ubiquitination

Animal Models and Experimental Medicine, EarlyView.
Based on a dermis fibroblast Gorab knockout mouse model, this study revealed that Gorab deficiency promotes skin aging by influencing RCHY1, causing a decrease in P53 ubiquitination, damaging the activity of HDAC2, further resulting in the accumulation of aging‐related proteins (P53, P21, P16) and a reduction in extracellular matrix (ECM) components ...
Yanhong Li, Wei Liang, Yanfeng Xu, Yunlin Han, Wenjie Zhao, Siyuan Wang, Wei Deng, Chuan Qin   +7 more
wiley   +1 more source

Oral administration of recombinant Lactobacillus plantarum co expressing FimB, CnaA, NetB and FBA antigens targeting chicken dendritic cells provides effective protection against necrotizing enteritis in broilers. [PDF]

Poult Sci
Yang T, Wang T, Zhang G, Guo Q, Zhang Y, Gao Y, Sun Y, Zhang Y, Wen X, Lu X, Xu Y, Wang Y, Du L, Huang H, Zou S, Wang Z, Wang C, Jiang Y.   +17 more
europepmc   +1 more source

Targeting high endothelial venules: potential strategies for cancer treatment. [PDF]

Ann Med
Yang W, Zhu G, Cai S, Xing H, Yang A, Ye X.   +5 more
europepmc   +1 more source

Vaccinia virus armed with IL-21 can cure murine colorectal cancer liver metastases via intravenous administration. [PDF]

J Immunother Cancer
Wang N, He Y, Yu J, Xia Y, Jia Y, Liu R, Zhang Y, Liu Y, Ning S, Chard Dunmall LS, Zhang Z, Wang Y.   +11 more
europepmc   +1 more source