Carbohydrate receptor-mediated gene transfer to human T leukaemic cells [PDF]
, 1994 The mucin-type carbohydrate Tn cryptantigen (GalNAcα1-O-Ser/Thr, where GalNAc is N-acetyl-D-galactosamine) is expressed in many carcinomas, in haemopoietic disorders including the Tn syndrome, and on human immunodeficiency virus (HIV) coat glycoproteins,
Berger, Eric G. +8 more
core +2 more sources
Tumor-associated Carbohydrate Antigens: Sialyl Lea and T/Tn Antigens in Canine Mammary Tumors [PDF]
Veterinary Pathology, 2009 Twenty-eight canine mammary tubulopapillary carcinomas and 14 simple adenomas were studied by immunohistochemistry for the expressions of the tumor-associated carbohydrate antigens. Sialyl Lea was detected in 71.42% of the malignant and 92.84% of the benign tumors.
M, Nowak +5 more
openaire +2 more sources
Cell surface-specific N-glycan profiling in breast cancer [PDF]
, 2013 Aberrant changes in specific glycans have been shown to be associated with immunosurveillance, tumorigenesis, tumor progression and metastasis. In this study, the N-glycan profiling of membrane proteins from human breast cancer cell lines and tissues was
Chen, Cuiying +8 more
core +4 more sources
Tobacco Mosaic Virus as a New Carrier for Tumor Associated Carbohydrate Antigens [PDF]
Bioconjugate Chemistry, 2012 Tumor-associated carbohydrate antigens (TACAs) are being actively studied as targets for antitumor vaccine development. One serious challenge was the low immunogenecity of these antigens. Herein, we report the results of using the tobacco mosaic virus (TMV) capsid as a promising carrier of a weakly immunogenic TACA, the monomeric Tn antigen. The copper(
Yin, Zhaojun +8 more
openaire +3 more sources
Alternative antibody for the detection of CA19-9 antigen: a European multicenter study for the evaluation of the analytical and clinical performance of the Access (R) GI Monitor assay on the UniCel (R) Dxl 800 Immunoassay System [PDF]
, 2008 Background: Gastrointestinal cancer antigen CA19-9 is known as a valuable marker for the management of patients with pancreatic cancer. Methods: The analytical and clinical performance of the Access(R) GI Monitor assay (Beckman Coulter) was evaluated on ...
Barone D +15 more
core +3 more sources
BMC Cancer, 2008 Background The number of breast cancer patients diagnosed with ductal carcinoma in situ (DCIS) continues to grow. Laboratory and clinical data indicate that DCIS can progress to invasive disease.
Kieber-Emmons Thomas +3 more
doaj +1 more source
Potential benefits and risks of clinical xenotransplantation [PDF]
, 2012 The transplantation of organs and cells from pigs into humans could overcome the critical and continuing problem of the lack of availability of deceased human organs and cells for clinical transplantation.
Ayares, D, Cooper, DKC
core +2 more sources
Tumor-Associated Glycans and Immune Surveillance
Vaccines, 2013 Changes in cell surface glycosylation are a hallmark of the transition from normal to inflamed and neoplastic tissue. Tumor-associated carbohydrate antigens (TACAs) challenge our understanding of immune tolerance, while functioning as immune targets that
Anastas Pashov +2 more
doaj +1 more source
Biomedicines, 2023 Background: Suppressor of fused (SuFu) is a tumor-suppressor gene that regulates hedgehog signaling. Its involvement in some malignancies is broadly accepted. However, its association with colorectal cancer (CRC) pathogenesis is not clear.
Tahseen Bilal Rather +11 more
doaj +1 more source
Chemoenzymatic Syntheses of Tumor‐Associated Carbohydrate Antigen Globo‐H and Stage‐Specific Embryonic Antigen 4 [PDF]
Advanced Synthesis & Catalysis, 2008 AbstractGangliosides have attracted much attention due to their important biological properties. Herein we report the first chemoenzymatic syntheses of two globo series of ganglioside oligosaccharides, Globo‐H 1 and stage‐specific embryonic antigen‐4 (SSEA‐4) 2.
Zhen, Wang +9 more
openaire +2 more sources