Results 51 to 60 of about 44,256 (203)
State of the Art in CAR-T Cell Therapy for Solid Tumors: Is There a Sweeter Future?
CellsChimeric antigen receptor (CAR)-T cell therapy has proven to be a powerful treatment for hematological malignancies. The situation is very different in the case of solid tumors, for which no CAR-T-based therapy has yet been approved.
Beatriz Amorós-Pérez +4 more
doaj +1 more source
Appearance of Inflammation in Peripheral Blood during Menstrual Cycles in Women of Childbearing Age
Reproductive and Developmental Medicine, 2018 Background: Chronic inflammation has been reported as a triggering and driving factor in the pathogenesis of various diseases and is believed to be closely associated with tumor pathogenesis.
Hai-Lun Liu +5 more
doaj +1 more source
A novel autoantibody signatures for enhanced clinical diagnosis of pancreatic ductal adenocarcinoma
Cancer Cell International, 2023 Background Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease that requires precise diagnosis for effective treatment. However, the diagnostic value of carbohydrate antigen 19 − 9 (CA19-9) is limited.
Tiandong Li +9 more
doaj +1 more source
Cancer biomarkers, and novel techniques for detection [PDF]
, 2017 Technologies for early detection of tumors is critical for better therapy outcome and overall change in cancer survival. These assays must be capable of detecting tumors at early stages in order to prevent metastasis of the tumor and help reduce ...
Jamal, Tameem
core
MGL Receptor and Immunity: When the Ligand Can Make the Difference
Journal of Immunology Research, 2015 C-type lectin receptors (CLRs) on antigen-presenting cells (APCs) facilitate uptake of carbohydrate antigens for antigen presentation, modulating the immune response in infection, homeostasis, autoimmunity, allergy, and cancer.
Ilaria Grazia Zizzari +7 more
doaj +1 more source
Frontiers in Molecular Biosciences, 2021 The α-gal epitope is a carbohydrate antigen which appeared early in mammalian evolution and is synthesized in large amounts by the glycosylation enzyme α1,3galactosyltransferase (α1,3GT) in non-primate mammals, lemurs, and New-World monkeys.
Uri Galili
doaj +1 more source
Challenges in Antibody Development against Tn and Sialyl-Tn Antigens
Biomolecules, 2015 The carbohydrate antigens Tn and sialyl-Tn (STn) are expressed in most carcinomas and usually absent in healthy tissues. These antigens have been correlated with cancer progression and poor prognosis, and associated with immunosuppressive ...
Liliana R. Loureiro +6 more
doaj +1 more source
Graphene Quantum Dot-Based Electrochemical Immunosensors for Biomedical Applications [PDF]
, 2019 In the area of biomedicine, research for designing electrochemical sensors has evolved over the past decade, since it is crucial to selectively quantify biomarkers or pathogens in clinical samples for the efficacious diagnosis and/or treatment of various
Altintas, Zeynep, Mansuriya, Bhargav D.
core +1 more source
Establishment of a Human Monoclonal Antibody to Hanganutziu‐Deicher Antigen as a Tumor‐associated Carbohydrate Antigen [PDF]
Japanese Journal of Cancer Research, 1988 We have established a human‐human hybridoma producing a monoclonal antibody against a tumor‐associated carbohydrate‐specific antigen, Hanganutziu‐Deicher (HD) antigen. Human spleen lymphocytes from a patient with esophageal varices complicated with liver cirrhosis were cultured in serum‐free medium and co‐stimulated with both anti‐human μ‐chain ...
Usuba, Osamu +4 more
openaire +2 more sources
Beilstein Journal of Organic Chemistry, 2014 Vaccination strategies based on dendritic cells (DCs) armed with specific tumor antigens have been widely exploited due the properties of these immune cells in coordinating an innate and adaptive response.
Renato Ribeiro-Viana +6 more
doaj +1 more source